LOCUS       HUMASGPR1               1277 bp    mRNA    linear   HUM 31-OCT-1994
DEFINITION  Human asialoglycoprotein receptor H1 mRNA, complete cds.
ACCESSION   M10058
VERSION     M10058.1
KEYWORDS    asialoglycoprotein receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Spiess,M., Schwartz,A.L. and Lodish,H.F.
  TITLE     Sequence of human asialoglycoprotein receptor cDNA. An internal
            signal sequence for membrane insertion
  JOURNAL   J. Biol. Chem. 260 (4), 1979-1982 (1985)
   PUBMED   2982798
COMMENT     Original source text: Human hepatoma cell line Hep G2, cDNA to
            mRNA, clone A21.
            Draft entry and sequence in computer-readable form for [1] kindly
            provided by M.Spiess, 03-SEP-1985.
            The asialoglycoprotein receptor is expressed exclusively in hepatic
            parenchymal cells in mammals.  After ligand binding to the
            receptor, the resulting complex is internalized and transported to
            a sorting organelle, where receptor and ligand are disassociated.
            The receptor then returns to the cell membrane surface.  The
            membrane spanning region of the protein is encoded by nucleotides
            300 to 356.  This region might function as an internal hydrophobic
            membrane insertion signal.  There is no proteolytic processing of
            the protein and no signal peptide.  [1] is not sure of the 5' end
            of the mRNA.
FEATURES             Location/Qualifiers
     source          1..1277
                     /db_xref="H-InvDB:HIT000194075"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="17pter-p12"
     gene            1..1277
                     /gene="ASGR1"
     mRNA            <1..>1277
                     /gene="ASGR1"
                     /product="ASGP-R1 mRNA"
     CDS             173..1048
                     /gene="ASGR1"
                     /note="asialoglycoprotein receptor H1"
                     /codon_start=1
                     /protein_id="AAA51785.1"
                     /db_xref="GDB:G00-118-754"
                     /translation="MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLL
                     SLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKM
                     KSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVE
                     HERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQN
                     GPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWV
                     CETELDKASQEPPLL"
BASE COUNT          271 a          394 c          378 g          234 t
ORIGIN      70 bp upstream of HindIII site.
        1 agggccctcc tatggaccct gcccgctccc ctcccattgt ccacggctgt ccgcccaccc
       61 ccattctcca agcttcagcc ccctccttag ttcggcatct gcacagcact gaagaacctg
      121 ggaatcagac cctgagaccc tgagcaatcc caggtccagc gccagcccta tcatgaccaa
      181 ggagtatcaa gaccttcagc atctggacaa tgaggagagt gaccaccatc agctcagaaa
      241 agggccacct cctccccagc ccctcctgca gcgtctctgc tccggacctc gcctcctcct
      301 gctctccctg ggcctcagcc tcctgctgct tgtggttgtc tgtgtgatcg gatcccaaaa
      361 ctcccagctg caggaggagc tgcggggcct gagagagacg ttcagcaact tcacagcgag
      421 cacggaggcc caggtcaagg gcttgagcac ccagggaggc aatgtgggaa gaaagatgaa
      481 gtcgctagag tcccagctgg agaaacagca gaaggacctg agtgaagatc actccagcct
      541 gctgctccac gtgaagcagt tcgtgtctga cctgcggagc ctgagctgtc agatggcggc
      601 gctccagggc aatggctcag aaaggacctg ctgcccggtc aactgggtgg agcacgagcg
      661 cagctgctac tggttctctc gctccgggaa ggcctgggct gacgccgaca actactgccg
      721 gctggaggac gcgcacctgg tggtggtcac gtcctgggag gagcagaaat ttgtccagca
      781 ccacataggc cctgtgaaca cctggatggg cctccacgac caaaacgggc cctggaagtg
      841 ggtggacggg acggactacg agacgggctt caagaactgg aggccggagc agccggacga
      901 ctggtacggc cacgggctcg gaggaggcga ggactgtgcc cacttcaccg acgacggccg
      961 ctggaacgac gacgtctgcc agaggcccta ccgctgggtc tgcgagacag agctggacaa
     1021 ggccagccag gagccacctc tcctttaatt tatttcttca atgcctcgac ctgccgcagg
     1081 ggtccgggat tgggaatccg cccatctggg gcctcttctg ctttctcggg aattttcatc
     1141 taggatttta agggaagggg aaggataggg tgatgttccg aaggtgagga gcttgaaacc
     1201 cgtggcgctt tctgcagttc acaatgataa cctgcaaact gcagaaagcg ccacgggttt
     1261 caagctcctc accttcg
//