LOCUS HUMPHKI 1002 bp mRNA linear HUM 24-JUL-1996
DEFINITION Homo sapiens phosphomevalonate kinase mRNA, complete cds.
ACCESSION L77213
VERSION L77213.1
KEYWORDS cholesterol biosynthesis; kinase; peroxisomal; phosphomevalonate
kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1002)
AUTHORS Chambliss,K.L., Slaughter,C.A., Schreiner,R., Hoffmann,G.F. and
Gibson,K.M.
TITLE Molecular cloning of human phosphomevalonate kinase and
identification of a consensus peroxisomal targeting sequence
JOURNAL J. Biol. Chem. 271 (29), 17330-17334 (1996)
PUBMED 8663599
COMMENT Original source text: Homo sapiens (clone library: Stratagene)
adult liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1002
/db_xref="H-InvDB:HIT000194009"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
/clone_lib="Stratagene"
/dev_stage="adult"
/note="(vector lambda ZAPII)"
mRNA 1..1002
5'UTR 1..35
CDS 36..614
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="phosphomevalonate kinase"
/protein_id="AAC37593.1"
/translation="MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLS
GPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQP
IWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDN
FGDFDWVIENHGVEQRLEEQLENLIEFIRSRL"
misc_feature 603..611
/function="encodes peroxisomal targeting sequence"
3'UTR 615..1002
regulatory 984..989
/regulatory_class="polyA_signal_sequence"
polyA_site 1002
BASE COUNT 208 a 251 c 339 g 204 t
ORIGIN
1 ccgcgatcta gaactagtcg aggcgtggcg gccccatggc cccgctggga ggcgccccgc
61 ggctggtact gctgttcagc ggcaagagga aatccgggaa ggacttcgtg accgaggcgc
121 tgcagagcag acttggagct gatgtctgtg ctgtcctccg gctctctggt ccactcaagg
181 aacagtatgc tcaggagcat ggcttgaact tccagagact cctggacacc agcacctaca
241 aggaggcctt tcggaaggac atgatccgct ggggagagga gaaacgccag gctgacccag
301 gcttcttttg caggaagatt gtggagggca tctcccagcc catctggctg gtgagtgaca
361 cacggagagt gtctgacatc cagtggtttc gggaggccta tggggccgtg acgcagacgg
421 tccgcgttgt agcgttggag cagagccgac agcagcgggg ctgggtgttc acgccagggg
481 tggacgatgc tgagtcagaa tgtggcctgg acaacttcgg ggactttgac tgggtcatcg
541 agaaccatgg agttgaacag cgcctggagg agcagttgga gaacctgata gaatttatcc
601 gctccagact ttagtcacta ggttctagga gtgagctggg gcctgctgag gtgggggtgg
661 ggctgactct gcaaaatggg ggtgtccccc gatcctggcc gaggtgagga acagacaggg
721 ggggtctaga ttctgagggg gttggtggat attgggcaag gcaggaaacc tctggagacc
781 tcattttctc catggggaag acagccatgc tcttcaggag gagactccaa gggcaaagga
841 gggtgtcttg gctgtgcttg aaggcgaaac cctgccatat ccccagtgcc agtcccctca
901 gcctgtggtg gccttgcatc ctgactggat gttctcagcc ccttgttctg ggcaagaacc
961 cagagctccc cagtgtggat actaataaac ctcttggagc ac
//