LOCUS HUMMGLUA 6384 bp mRNA linear HUM 01-AUG-1996
DEFINITION Homo sapiens metabotropic glutamate receptor 1 alpha (mGluR1alpha)
mRNA, complete cds.
ACCESSION L76627
VERSION L76627.1
KEYWORDS glutamate; metabotropic; metabotropic glutamate receptor 1 alpha;
receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6384)
AUTHORS Stephan,D., Bon,C., Holzwarth,J.A., Galvan,M. and Pruss,R.M.
TITLE Human metabotropic glutamate receptor 1: mRNA distribution,
chromosome localization and functional expression of two splice
variants
JOURNAL Unpublished
COMMENT Original source text: Homo sapiens (clone: 5.6kb) (clone library:
Clontech HL1137y) cDNA to mRNA; and Homo sapiens (clone: 3.3kb)
(clone library: Clontech HL1137y) cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..6384
/db_xref="H-InvDB:HIT000193983"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
source 1..785
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="3.3kb"
/clone_lib="Clontech HL1137y"
source 786..6384
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="5.6kb"
/clone_lib="Clontech HL1137y"
gene 1..6384
/gene="mGluR1alpha"
mRNA <1..6384
/gene="mGluR1alpha"
/note="alpha splice variant"
CDS 1..3585
/gene="mGluR1alpha"
/codon_start=1
/product="metabotropic glutamate receptor 1 alpha"
/protein_id="AAB05337.1"
/translation="MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGD
VIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLG
SEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVI
GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI
VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRK
LRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEA
NGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKR
ICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKL
LDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNID
DYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACD
LGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVK
SSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRI
ARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIK
EVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIW
LAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVV
RMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLS
VHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPG
SPSMVVHRRVPSAATTPPLPPHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSL
MDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEE
LVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALT
PPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL"
3'UTR 3586..6384
/gene="mGluR1alpha"
regulatory 6364..6369
/regulatory_class="polyA_signal_sequence"
/gene="mGluR1alpha"
polyA_site 6384
/gene="mGluR1alpha"
BASE COUNT 1658 a 1545 c 1485 g 1696 t
ORIGIN
1 atggtcgggc tccttttgtt ttttttccca gcgatctttt tggaggtgtc ccttctcccc
61 agaagccccg gcaggaaagt gttgctggca ggagcgtcgt ctcagcgctc ggtggccaga
121 atggacggag atgtcatcat tggagccctc ttctcagtcc atcaccagcc tccggccgag
181 aaagtgcccg agaggaagtg tggggagatc agggagcagt atggcatcca gagggtggag
241 gccatgttcc acacgttgga taagatcaac gcggacccgg tcctcctgcc caacatcacc
301 ctgggcagtg agatccggga ctcctgctgg cactcttccg tggctctgga acagagcatt
361 gagttcatta gggactctct gatttccatt cgagatgaga aggatgggat caaccggtgt
421 ctgcctgacg gccagtccct ccccccaggc aggactaaga agcccattgc gggagtgatc
481 ggtcccggct ccagctctgt agccattcaa gtgcagaacc tgctccagct cttcgacatc
541 ccccagatcg cttattcagc cacaagcatc gacctgagtg acaaaacttt gtacaaatac
601 ttcctgaggg ttgtcccttc tgacactttg caggcaaggg ccatgcttga catagtcaaa
661 cgttacaatt ggacctatgt ctctgcagtc cacacggaag ggaattatgg ggagagcgga
721 atggacgctt tcaaagagct ggctgcccag gaaggcctct gtatcgccca ttctgacaaa
781 atctacagca acgctgggga gaagagcttt gaccgactct tgcgcaaact ccgagagagg
841 cttcccaagg ctagagtggt ggtctgcttc tgtgaaggca tgacagtgcg aggactcctg
901 agcgccatgc ggcgccttgg cgtcgtgggc gagttctcac tcattggaag tgatggatgg
961 gcagacagag atgaagtcat tgaaggttat gaggtggaag ccaacggggg aatcacgata
1021 aagctgcagt ctccagaggt caggtcattt gatgattatt tcctgaaact gaggctggac
1081 actaacacga ggaatccctg gttccctgag ttctggcaac atcggttcca gtgccgcctt
1141 ccaggacacc ttctggaaaa tcccaacttt aaacgaatct gcacaggcaa tgaaagctta
1201 gaagaaaact atgtccagga cagtaagatg gggtttgtca tcaatgccat ctatgccatg
1261 gcacatgggc tgcagaacat gcaccatgcc ctctgccctg gccacgtggg cctctgcgat
1321 gccatgaagc ccatcgacgg cagcaagctg ctggacttcc tcatcaagtc ctcattcatt
1381 ggagtatctg gagaggaggt gtggtttgat gagaaaggag acgctcctgg aaggtatgat
1441 atcatgaatc tgcagtacac tgaagctaat cgctatgact atgtgcacgt tggaacctgg
1501 catgaaggag tgctgaacat tgatgattac aaaatccaga tgaacaagag tggagtggtg
1561 cggtctgtgt gcagtgagcc ttgcttaaag ggccagatta aggttatacg gaaaggagaa
1621 gtgagctgct gctggatttg cacggcctgc aaagagaatg aatatgtgca agatgagttc
1681 acctgcaaag cttgtgactt gggatggtgg cccaatgcag atctaacagg ctgtgagccc
1741 attcctgtgc gctatcttga gtggagcaac atcgaatcca ttatagccat cgccttttca
1801 tgcctgggaa tccttgttac cttgtttgtc accctaatct ttgtactgta ccgggacaca
1861 ccagtggtca aatcctccag tcgggagctc tgctacatca tcctagctgg catcttcctt
1921 ggttatgtgt gcccattcac tctcattgcc aaacctacta ccacctcctg ctacctccag
1981 cgcctcttgg ttggcctctc ctctgcgatg tgctactctg ctttagtgac taaaaccaat
2041 cgtattgcac gcatcctggc tggcagcaag aagaagatct gcacccggaa gcccaggttc
2101 atgagtgcct gggctcaggt gatcattgcc tcaattctga ttagtgtgca actaaccctg
2161 gtggtaaccc tgatcatcat ggaaccccct atgcccattc tgtcctaccc aagtatcaag
2221 gaagtctacc ttatctgcaa taccagcaac ctgggtgtgg tggccccttt gggctacaat
2281 ggactcctca tcatgagctg tacctactat gccttcaaga cccgcaacgt gcccgccaac
2341 ttcaacgagg ccaaatatat cgcgttcacc atgtacacca cctgtatcat ctggctagct
2401 tttgtgccca tttactttgg gagcaactac aagatcatca caacttgctt tgcagtgagt
2461 ctcagtgtaa cagtggctct ggggtgcatg ttcactccca agatgtacat cattattgcc
2521 aagcctgaga ggaatgtccg cagtgccttc accacctctg atgttgtccg catgcatgtt
2581 ggcgatggca agctgccctg ccgctccaac actttcctca acatcttccg aagaaagaag
2641 gcaggggcag ggaatgccaa ttctaatggc aagtctgtgt catggtctga accaggtgga
2701 ggacaggtgc ccaagggaca gcatatgtgg caccgcctct ctgtgcacgt gaagaccaat
2761 gagacggcct gcaaccaaac agccgtcatc aaacccctca ctaaaagtta ccaaggctct
2821 ggcaagagcc tgaccttttc agataccagc accaagaccc tttacaacgt agaggaggag
2881 gaggatgccc agccgattcg ctttagcccg cctggtagcc cttccatggt ggtgcacagg
2941 cgcgtgccaa gcgcggcgac cactccgcct ctgccgcccc acctgaccgc agaggagacc
3001 cccctcttcc tggccgaacc agccctcccc aagggcttgc cccctcctct ccagcagcag
3061 cagcaacccc ctccacagca gaaatcgctg atggaccagc tccagggagt ggtcagcaac
3121 ttcagtaccg cgatcccgga ttttcacgcg gtgctggcag gccccggggg tcccgggaac
3181 gggctgcggt ccctgtaccc gcccccgcca ccgccgcagc acctgcagat gctgccgctg
3241 cagctgagca cctttgggga ggagctggtc tccccgcccg cggacgacga cgacgacagc
3301 gagaggttta agctcctcca ggagtacgtg tatgagcacg agcgggaagg gaacacggaa
3361 gaagacgaac tggaagagga ggaggaggac ctgcaggcgg ccagcaaact gaccccggat
3421 gattcgcctg cgctgacgcc tccgtcgcct ttccgcgact cggtggcctc gggcagctcg
3481 gtgcccagct ccccagtgtc cgagtcggtg ctctgcaccc ctcccaacgt atcctacgcc
3541 tctgtcattc tgcgggacta caagcaaagc tcttccaccc tgtaaggggg aagggtccac
3601 atagaaaagc aagacaagcc agagatctcc cacacctcca gagatgtgca aacagctggg
3661 aggaaaagcc tgggagtggg gggcctcgtc gggaggacag gagaccgctg ctgctgctgc
3721 cgctactgct gctgctgcct taagtaggaa gagagggaag gacaccaagc aaaaaatgtt
3781 caggccagga ttcggattct tgaattactc gaagccttct ctgggaagaa agggaattct
3841 gacaaagcac aattccatat ggtatgtaac ttttatcaca aatcaaatag tgacatcaca
3901 aacataatgt cctcttttgc acaattgtgc atagatatat atatgcccac acacactggg
3961 ccatgcttgg caaggaacag accacgtggc atccagtcgg atcatgagtt cacctgatgc
4021 attcggagtg agctggtgga gccagacaga gcaggtgcgg ggaagggaag ggccaggcca
4081 gacccatccc aaacggatga tgggatgatg ggacagcagt tccttgctca gaagcccttc
4141 tccccgctgg gctgacagac tcctcatctt caggagactc aggaatggag cggtacaggg
4201 gtctctcttc atccaccgca acccatccag tgccagcttt gagattgcac ttgaagaaag
4261 gtgcatggac cccctgctgc tctgcagatt ccctttattt aggaaaacag gaataagagc
4321 aaaattatca ccaaaaagtg cttcatcagg cgtgctacag gaggaaggag ctagaaatag
4381 aacaatccat cagcatgaga ctttgaaaaa aaaaacacat gatcagcttc tcatgttcca
4441 tattcactta ttggcgattt ggggaaaagg ccggaacaag agattgttac gagagtggca
4501 gaaacccttt tgtagattga cttgtgtttg tgccaagcgg gctttccatt gaccttcagt
4561 taaagaacaa accatgtgac aaaattgtta ccttccactt actgtagcaa ataataccta
4621 caagttgaac ttctaagatg cgtatatgta caatttggtg ccattatttc tcctacgtat
4681 tagagaaaca aatccatctt tgaatctaat ggtgtactca tagcaactat tactggttta
4741 aatgacaaat aattctatcc tattgtcact gaagtccttg taactagcga gtgaatgtgt
4801 tcctgtgtcc ttgtatatgt gcgatcgtaa aatttgtgca atgtaatgtc aaattgacct
4861 gtcaatgtca acctagtagt caatctaact gcaattagaa attgtctttt gaatatacta
4921 tatatatttt ttatgttcca ataatgtttt atacatcatt gtcatcaata tctacagaag
4981 ctctttgacg gtttgaatac tatggctcaa ggttttcata tgcagctcgg atggacattt
5041 ttcttctaag atggaactta tttttcagat attttctgat gtggagatat gttattaatg
5101 aagtggtttg aaaatttgtt atattaaaag tgcacaaaaa ctgagagtga aaataaaagg
5161 tacattttat aagcttgcac acattattaa cacataagat tgaacaaagc atttagatta
5221 ttccaggtta tatcattttt ttaaagattt tccacagcta cttgagtgtc taacatacag
5281 taacatctaa ctcagctaat aatttgtaaa atctttatca atcacattgt ggcctctttt
5341 aatttttatg ttcatggact tttattcctg tgtcttggct gtcataactt tttatttctg
5401 ctatttgctg ttgtgtaata tccatggaca tgtaatccac ttactccatc tttacaatcc
5461 ctttttacca ccaataaaag gattttttct tgctgttttg atttcttcta ttatttgtgg
5521 aatgaattat acccccctta aatatctttg tttatgcctt atgttcagtc atattttaat
5581 atgcttcctt catattgaag ctgctgattt ctcagccaaa aatcatctta gaatctttaa
5641 atatccattg catcatttgt tcagaattta acatccattc caatgttgga ggcttgtatt
5701 acttatattt catcatattc tattgccaag tttagtcagt tccacaccaa gaatgaactg
5761 catttccttt aaaaattatt ttaaaacacc tttattgaaa agatctcatg actgagatgt
5821 ggactttggt tccatgtttt cattgtaaga aagcagagag cggaaaatca atggctccag
5881 tgattaatag atgggttttt agtaattgac aaattcatga gggaaagcat atgatctctt
5941 tattagtgaa tcatgcttat tttttactct taacgccact aatatacatc cctaatatca
6001 cagggcttgt gcattcagat ttttaaaaaa ttaggataga taaggaaaca acttatattc
6061 aagtgtaaga tgatatcagg ttggtctaag acttttggtg aacacgttca ttcaactgtg
6121 atcactttat tactctgaat gcctactatt atcctgatta tggggtctcc tgaataaata
6181 gagtattagt ctttatgtca tcattgttca aaattggaga tgtacacata cataccctat
6241 accaagaggg ccgaaactct tcaccttgat gtatgttctg atacaagttg ttcagcttct
6301 tgtaaatgtg ttttccttcg gcttgttact gccttttgtc aaataatctt gacaatgctg
6361 tataataaat attttctatt tatt
//