LOCUS HUMFMR2R 7315 bp mRNA linear HUM 13-JUL-2009
DEFINITION Homo sapiens fragile X E mental retardation syndrome protein (FMR2)
mRNA, complete cds.
ACCESSION L76569
VERSION L76569.1
KEYWORDS CpG island associated sequence; fmr2 gene; fragile X E mental
retardation; fragile X E mental retardation syndrome protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7315)
AUTHORS Gu,Y., Shen,Y., Gibbs,R.A. and Nelson,D.L.
TITLE Identification of FMR2, a novel gene associated with the FRAXE CCG
repeat and CpG island
JOURNAL Nat. Genet. 13 (1), 109-113 (1996)
PUBMED 8673086
COMMENT On May 11, 1996 this sequence version replaced gi:1311523.
FEATURES Location/Qualifiers
source 1..7315
/db_xref="H-InvDB:HIT000193982"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="B5P6C4"
/clone="cYG3"
/tissue_type="brain"
/dev_stage="fetus"
gene 1..7315
/gene="FMR2"
5'UTR 1..392
/gene="FMR2"
CDS 393..4223
/gene="FMR2"
/codon_start=1
/product="fragile X E mental retardation syndrome protein"
/protein_id="AAA99416.1"
/db_xref="GDB:141566"
/translation="MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLF
SSGFDLFGEPYKTNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNP
NNKNEPSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSH
NPSTVLASQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNP
NSSGEDAFKEIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSM
GQQKPTAYVRPMDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLP
KFTILQTSEVSLPSDPSCVEEILRESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLED
DLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLVTPQPPPAVQASGG
SGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQN
KSFICGPNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPR
PTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKE
KESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDS
STSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISN
EEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKET
ATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPP
HKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTG
QITSTKPKRTEGKFCATFKGISEGDTPKKASSATITVTNTAIATATVTATAIVTTTVT
ATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTF
DDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSP
YTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKY
SRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRI
HHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYV
RQGLCWLRIDAHLL"
3'UTR 4224..7315
/gene="FMR2"
BASE COUNT 2119 a 1824 c 1550 g 1822 t
ORIGIN
1 cggcggcggc ggcggcggcg gccgcccccg ccgccgctgc cgccgccggc ccgcagccag
61 ccaggcgggc ggcccagccc gcctgagccc gcagcggctg ccgccgcagc gtcgggtcgc
121 tgggtgcgcg ggctaccgcg gaccgagcgg acccgagtgg gcgaccaggc gcttgcccgc
181 ccagtgccac tgccgccgct tcctcgccgg agcacaggac cagacacctc cagcgcccgc
241 tgctgctgcc gatgcggccc ggacactttt agctgggcgg gagggctgga gagccggggg
301 ccgccgagaa ccgccagcga gctgtgccga gagccgcgcc gacccgctgc gatcagggac
361 aggcgcccgc ccgccgccgc cgcctggccg ctatggatct attcgacttt ttcagagact
421 gggacttgga gcagcagtgt cactatgaac aagaccgtag tgcacttaaa aaaagggaat
481 gggagcggag gaatcaagaa gtccagcaag aagacgatct cttttcttca ggctttgatc
541 tttttgggga gccatacaag acaaacaaag gtgatgcact tgccaaccga gtccagaaca
601 cgcttggaaa ctatgatgaa atgaagaatt tgctaactaa ccattctaat cagaatcacc
661 tagtgggaat tccaaagaat tctgtgcccc agaatcccaa caacaaaaat gaaccaagct
721 tttttccaga acaaaagaac agaataattc cacctcacca ggataatacc catccttcag
781 caccaatgcc tccaccttct gttgtgatac tgaattcaac tctaatacac agcaacagaa
841 aatcaaaacc tgagtggtca cgtgatagtc ataaccctag cactgtactg gcaagccagg
901 ccagtggtca gccaaacaag atgcagactt tgacacagga ccagtctcaa gccaaactgg
961 aagacttctt tgtctaccca gctgaacagc cccagattgg agaagttgaa gagtcaaacc
1021 catctgcaaa ggaagacagt aaccctaatt ctagtggaga agatgctttc aaagaaatct
1081 ttcaatccaa ttcaccggaa gaatctgaat tcgccgtgca agcgcctggg tctcccctag
1141 tggcttcctc tttattagct cctagcagtg gcctttcagt tcaaaacttc ccaccagggc
1201 tttactgcaa aacaagcatg gggcagcaaa agccaactgc atacgtcaga cccatggatg
1261 gccaggacca ggcaccggac atctcaccaa cactgaaacc ttcaattgaa tttgagaaca
1321 gctttgggaa tctgtcattt ggaacactct tggatggaaa acccagtgca gccagttcaa
1381 agactaaact gccaaagttc accatcctcc aaacaagtga agtaagcctt cccagtgatc
1441 caagctgtgt tgaagaaatc ttgcgggaat cgcagcatct gaccccagga ttcaccttac
1501 aaaagtggaa tgacccaacc accagagctt ctacaaagtc agtgtctttc aaatcgatgc
1561 ttgaggatga cctgaagctg agcagtgatg aagatgacct tgagcctgtg aagaccttga
1621 ccactcagtg cactgccact gagctctacc aggctgttga aaaggcaaaa cctaggaata
1681 atcctgtgaa cccacccttg gtcactcccc agcccccacc tgcagtgcaa gccagcgggg
1741 gttctggcag ctccagcgaa tcggagagca gctctgagtc ggattcagac actgaaagta
1801 gcaccactga cagcgaatct aatgaggcac ctcgtgtggc aactccagag cctgagccac
1861 cctcaaccaa caagtggcaa ctggataaat ggcttaacaa agtgacatcc cagaacaagt
1921 cttttatttg tggcccaaat gaaacaccca tggagactat ttctctgcct cctccaatca
1981 tccaaccaat ggaagtccag atgaaagtga agacgaatgc cagtcaggtc ccagctgaac
2041 ccaaagaaag gcctctcctc agtctcatta gggagaaagc ccgtccacgg cccactcaga
2101 aaattccaga aacaaaggct ttgaagcata agttgtcaac aactagtgag acagtgtctc
2161 aaaggacaat tgggaaaaaa cagcccaaaa aagttgagaa gaacaccagc actgacgagt
2221 ttacctggcc caaaccaaat attaccagca gcactcccaa agaaaaagaa agtgtggagc
2281 ttcatgaccc accaagaggc cgcaacaaag ccactgccca caaaccagcc cctaggaaag
2341 aaccaagacc taacatccct ttggctcccg agaagaagaa gtacagaggg cctggcaaga
2401 ttgtgccaaa gtctcgggaa ttcattgaaa cagattcatc tacatctgac tccaacacag
2461 atcaggaaga gaccctgcaa atcaaagtcc tgcctccgtg cattatttct ggaggtaata
2521 ctgccaaatc caaggaaatc tgtggtgcca gcctgaccct cagcacctta atgagtagca
2581 gtggcagcaa caacaactta tccatcagta atgaagagcc aacattttca cctattcctg
2641 tcatgcaaac tgaaatcctg tcccctctgc gagatcatga gaacctgaaa aacctctggg
2701 tgaagattga ccttgactta ctctctagag tacctggcca cagctcactc catgcagcac
2761 ctgccaagcc agaccacaag gagactgcca caaaacccaa gcgtcagaca gctgtcacag
2821 ctgtggagaa accagcccct aagggcaaac gtaagcacaa gccaatagaa gttgcagaga
2881 agatccctga gaagaagcag cgcctggagg aggccacaac tatctgcttg ctccctcctt
2941 gcatctcacc agccccaccc cacaagcctc ccaacactag agaaaataat tcatccagga
3001 gagcaaatag aagaaaggaa gaaaaactat ttcctcctcc actttcccca ctgccagagg
3061 accctccacg ccgcagaaat gtcagtggca ataatggtcc ctttggtcaa gacaaaaaca
3121 tcgccatgac tggacaaatc acatctacca aacctaagag aactgaaggc aaattctgtg
3181 ctactttcaa agggatatcg gagggagaca ctccaaaaaa ggcatcctct gccaccatca
3241 ctgtcaccaa tactgctatt gccactgcta ctgtcactgc tactgccatt gtcaccacca
3301 ctgtcacagc tactgccacc gccacggcca ccaccacaac tactaccact accatttcca
3361 ccatcacctc taccatcact actggcctca tggatagcag tcacctggag atgacgtcct
3421 gggcggctct gccccttcta tccagcagca gcactaatgt ccggagaccc aagctcactt
3481 ttgatgactc ggttcacaat gctgattatt acatgcaaga agctaagaag ctgaagcaca
3541 aagctgatgc actgttcgag aaatttggca aagctgtgaa ttatgctgat gccgccctct
3601 ccttcactga atgtggcaat gccatggaac gcgaccctct ggaagcaaag tccccataca
3661 ccatgtactc tgagactgtg gagctcctca ggtatgcaat gaggctgaag aactttgcaa
3721 gtcccttggc ttcggatggg gacaaaaagc tagcagtact atgctaccga tgtttatcac
3781 tcctctattt gagaatgttt aagctgaaga aggaccatgc tatgaagtac tccagatcac
3841 tgatggaata ttttaagcaa aatgcttcaa aagtcgcaca gataccctct ccatgggtaa
3901 gcaatggaaa gaacactcca tccccagtgt ctctcaacaa cgtctccccc atcaacgcaa
3961 tggggaactg taacaatggc ccagtcacca ttccccagcg cattcaccac atggctgcca
4021 gccacgtcaa catcactagc aatgtgttac ggggctatga acactgggat atggccgaca
4081 aactgacaag agaaaacaaa gaattctttg gtgatctgga cacgctgatg gggcctctga
4141 cccagcacag cagcatgacc aatcttgtcc gctacgttcg ccaaggactg tgttggctgc
4201 gcatcgatgc ccacttgttg tagtgggtgt tctcagatct ctagcatcac gacccatcac
4261 tctacctcta ccagcgcact gatggtcact ggtggaactc cactcactgg ggaacgttct
4321 ctttggttat gtttgttttt atgcttcttt tgttatctgt aaaaaacaga agtcattgta
4381 agttgacact acaacttaag ggcagtgtac gttttattac ttagtcattt tttttctttt
4441 agcatttgat atgcatttct cagattccac catctttttg tgctttatgg aatgacagtc
4501 cctacaatat tgttttaagc ccacactacc caaaacaaag aatgggaagc acttgtgata
4561 aagacaggct cctgagaaat gcaacaagtg gtcttacata tacatgagaa cttagacaca
4621 agggaccatc ccccaaactc tactcttata cccagaaaag aacatatttc agaatctgtc
4681 aaacttttgt gtatcccaca gattcaatct tcaggtgaga attttcattg tcaaaaccca
4741 ctggttagat gttgtagcaa catcataaaa tcaagagtat caagaaaata aatgagcata
4801 gcaatgctac tcttaaaaag atgctatgcc acacaaccag aggactttct tgttagcatc
4861 cctttcctga ttccctattt tgttaatttt aatgataaga agaaagggtg acatttattt
4921 tgacaagttt taggcatcag ctggcatcag tgtttttcaa ctccattatt tgaagtgtaa
4981 atcctcacct ggggttctct gtgtgcaaag ctgtcctttt gaagaacagt ttggttgatg
5041 catgccttag tagccaaaat gctacactct agacttacaa gtgggagtta agagaggtct
5101 ggaaagtgtc caacaaggaa ttcacacctc tgcctccttt gcaacaacaa catttacaca
5161 gttggtaagt gggtccataa ctggcaggat ttttaaattg tattttgctc aaatctatgg
5221 gaacaaaagt caaggtatca ctacctagaa gtaatgatat acagttttct tcctagtggc
5281 ttgaaaatct ggacttcctc aattattatt cacattttct ctcttatagg ttttctgttt
5341 tctactttct tttttctctt atctgtgttt ccctttcctt tgtttggctc attaactttt
5401 gactgaatta caattactcc ttttattaaa gtccatatta ttgtgaatca tttccatgaa
5461 aatttctaag aaaactccaa actctctaaa tagtagctaa cttttatttt tttaaaatga
5521 gtcgtggggt agtgcttcac cttgagatgc tttgaaagag ccctaaacat tgggaaccat
5581 tcacctaatt tggagacatt tctcactggt tgtgactacc cccttatgat ccttcacatt
5641 cattttatgt ccctaaacat cacaatgtaa atatcatttt tgatgttcca gctcaccaga
5701 agattcttac acttggggta aacactatcc atgcattact tactggtaat tacctgctgg
5761 tatataattc catgtagcct ttaatatgct gggttatcaa attctgttca ctgagttatg
5821 accagataaa taatagatat gcacatgaaa gatgcaaact tgtgtgatta ttaaagccag
5881 ccatgcaggt ccatgataga aacagcaggt gatgactctg cactctcatt gtcaaggtta
5941 gctatatccc cagttgcaaa acagccagac ttgagctgtg ctctggtcat ctttgagttt
6001 aaggcctttt gttgtataag gctgtggaag ttgtactcca atggctgaag ccatgttgtt
6061 aatatggctg atgggagcat ccctgcagct gaacccagca ctttttatgc tcccactgtg
6121 gttgagcttt atgtttacag tctcagcaac aacacttatg catccaaaca ctcacaaatg
6181 aaacctgaaa gaatcttttc tgagcctctt aaaagaggaa aatgatgata acattaaaga
6241 ctctgaacac ccaaggttgg tgtcacatat aaaaattaag ctgatgactt tgcagtgact
6301 caagttgtct ctttatcatg gtttaccagg tagagtgcct ggctattact atataatgaa
6361 gcccactggc ttgacttgta agttcaacct aaaccacaat cctagaccat catggattta
6421 ggagtagatt cttcttgaaa tcccacatcc agaaactaga cattagaatg ttgaggcagt
6481 ttcccagaga aacaagcata ttgcctcatg gatgaaagac ttgtagttct agtttcagtg
6541 acttgttata tctacttaca tacaacaggg aggcaagagg attctctgtc atctctggtg
6601 actgagtgta aaatatgtgc caagtctgca gcacagtgac caaatctgac aatcgagctc
6661 tggatcacca cttgattatg tagtagactc atttataaag cagcttagga actaattaaa
6721 catggaggat gaattacctt cctatccctt gagataagac atctttcagt ttcatgatta
6781 aggattgttg ctgttttata gttactctgt tcatcacagt gtaaatggtg atgcgtgtcg
6841 taggtgtgca gctatttgag ggactaaggg atggagatat tctgtcaaat gaatctcttc
6901 agtataccag tttgtgggag ggatatgaga catgtggatg gcagtgagag atcgtgcctc
6961 tagatcttga tggaggcttg gtgagacaca cttaaataag cacgtggagg ttagaataga
7021 gggcagagta aaaggaagct ccatctgagc aagtacacca aatgatctca gccctgcaac
7081 ttgacccagg tagggccacc actacgcctt cacttgtcac ccaagctcca accacagaga
7141 gtttgacaag tttgtgttat gatgttggct tggctttgta tttttaatta actttggatt
7201 tttagtggtt ttgtcatata actgtctgag tttggtaggt aggattactt tgaaaagggt
7261 ttactagtgt ggtcctccgg gtagaattta gctgtaagca tgttgttagc cagcc
//