LOCUS HUME51P 2229 bp mRNA linear HUM 26-SEP-1995
DEFINITION Homo sapiens S182 protein homologue (E5-1) mRNA, complete cds.
ACCESSION L44577
VERSION L44577.1
KEYWORDS Alzheimer's disease; S182 protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2229)
AUTHORS Rogaev,E.I., Sherrington,R., Rogaeva,E.A., Levesque,G., Ikeda,M.,
Liang,Y., Chi,H., Lin,C., Holman,K., Tsuda,T., Mar,L., Sorbi,S.,
Nacmias,B., Piacentini,S., Amaducci,L., Chumakov,I., Cohen,D.,
Lannfelt,L., Fraser,P.E., Rommens,J.M. and St George-Hyslop,P.H.
TITLE Familial Alzheimer's disease in kindreds with missense mutations in
a gene on chromosome 1 related to the Alzheimer's disease type 3
gene
JOURNAL Nature 376 (6543), 775-778 (1995)
PUBMED 7651536
COMMENT Original source text: Homo sapiens (clone: cc32) fetus and adult
brain and colon cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2229
/db_xref="H-InvDB:HIT000193897"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p36.1-p35"
/clone="cc32"
/cell_type="colon cancer cell"
/tissue_type="brain and colon"
/dev_stage="fetus and adult"
/germline
/note="other clones E5-1, cc54, g1-1; other clones E5-1,
cc54, g1-1"
gene 1..2229
/gene="E5-1"
5'UTR 1..365
/gene="E5-1"
CDS 366..1712
/gene="E5-1"
/function="homologue of the S182 gene product (acc#
L42110)"
/note="putative"
/codon_start=1
/product="E5-1 protein"
/protein_id="AAC42012.1"
/translation="MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENT
AQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVV
VATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVC
IHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEP
SYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACF
VAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI"
3'UTR 1710..2229
/gene="E5-1"
polyA_site 2229
/gene="E5-1"
BASE COUNT 481 a 579 c 633 g 521 t
ORIGIN
1 gaattcggca cgagggcatt tccagcagtg aggagacagc cagaagcaag cttttggagc
61 tgaaggaacc tgagacagaa gctagtcccc cctctgaatt ttactgatga agaaactgag
121 gccacagagc taaagtgact tttcccaagg tcgcccagcg aggacgtggg acttctcaga
181 cgtcaggaga gtgatgtgag ggagctgtgt gaccatagaa agtgacgtgt taaaaaccag
241 cgctgccctc tttgaaagcc agggagcatc attcatttag cctgctgaga agaagaaacc
301 aagtgtccgg gattcaagac ctctctgcgg ccccaagtgt tcgtggtgct tccagaggca
361 gggctatgct cacattcatg gcctctgaca gcgaggaaga agtgtgtgat gagcggacgt
421 ccctaatgtc ggccgagagc cccacgccgc gctcctgcca ggagggcagg cagggcccag
481 aggatggaga gaatactgcc cagtggagaa gccaggagaa cgaggaggac ggtgaggagg
541 accctgaccg ctatgtctgt agtggggttc ccgggcggcc gccaggcctg gaggaagagc
601 tgaccctcaa atacggagcg aagcatgtga tcatgctgtt tgtgcctgtc actctgtgca
661 tgatcgtggt ggtagccacc atcaagtctg tgcgcttcta cacagagaag aatggacagc
721 tcatctacac gccattcact gaggacacac cctcggtggg ccagcgcctc ctcaactccg
781 tgctgaacac cctcatcatg atcagcgtca tcgtggttat gaccatcttc ttggtggtgc
841 tctacaagta ccgctgctac aagttcatcc atggctggtt gatcatgtct tcactgatgc
901 tgctgttcct cttcacctat atctaccttg gggaagtgct caagacctac aatgtggcca
961 tggactaccc caccctcttg ctgactgtct ggaacttcgg ggcagtgggc atggtgtgca
1021 tccactggaa gggccctctg gtgctgcagc aggcctacct catcatgatc agtgcgctca
1081 tggccctagt gttcatcaag tacctcccag agtggtccgc gtgggtcatc ctgggcgcca
1141 tctctgtgta tgatctcgtg gctgtgctgt gtcccaaagg gcctctgaga atgctggtag
1201 aaactgccca ggagagaaat gagcccatat tccctgccct gatatactca tctgccatgg
1261 tgtggacggt tggcatggcg aagctggacc cctcctctca gggtgccctc cagctcccct
1321 acgacccgga gatggaagaa gactcctatg acagttttgg ggagccttca taccccgaag
1381 tctttgagcc tcccttgact ggctacccag gggaggagct ggaggaagag gaggaaaggg
1441 gcgtgaagct tggcctcggg gacttcatct tctacagtgt gctggtgggc aaggcggctg
1501 ccacgggcag cggggactgg aataccacgc tggcctgctt cgtggccatc ctcattggct
1561 tgtgtctgac cctcctgctg cttgctgtgt tcaagaaggc gctgcccgcc ctccccatct
1621 ccatcacgtt cgggctcatc ttttacttct ccacggacaa cctggtgcgg ccgttcatgg
1681 acaccctggc ctcccatcag ctctacatct gagggacatg gtgtgccaca ggctgcaagc
1741 tgcagggaat tttcattgga tgcagttgta tagttttaca ctctagtgcc atatattttt
1801 aagacttttc tttccttaaa aaataaagta cgtgtttact tggtgaggag gaggcagaac
1861 cagctctttg gtgccagctg tttcatcacc agactttggc tcccgctttg gggagcgcct
1921 cgcttcacgg acaggaagca cagcaggttt atccagatga actgagaagg tcagattagg
1981 gtggggagaa gagcatccgg catgagggct gagatgccca aagagtgtgc tcgggagtgg
2041 cccctggcac ctgggtgctc tggctggaga ggaaaagcca gttccctacg aggagtgttc
2101 ccaatgcttt gtccatgatg tccttgttat tttattnccy ttanaaactg antcctnttn
2161 ttnttdcggc agtcacmctn ctgggragtg gcttaatagt aanatcaata aanagntgag
2221 tcctnttag
//