LOCUS HUMSTM2R 2236 bp mRNA linear HUM 23-AUG-1995
DEFINITION Homo sapiens (clone F-T03796) STM-2 mRNA, complete cds.
ACCESSION L43964
VERSION L43964.1
KEYWORDS Alzheimer's disease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2236)
AUTHORS Levy-Lahad,E., Wasco,W., Poorkaj,P., Romano,D.M., Oshima,J.,
Pettingell,W.H., Yu,C.-E., Jondro,P.D., Schmidt,S.D., Wang,K.,
Crowley,A.C., Fu,Y.-H., Guenette,S.Y., Galas,D., Nemens,E.,
Wijsman,E.M., Bird,T.D., Schellenberg,G.D. and Tanzi,R.E.
TITLE Candidate gene for the chromosome 1 familial Alzheimer's disease
locus
JOURNAL Science 269 (5226), 973-977 (1995)
PUBMED 7638622
COMMENT Original source text: Homo sapiens (clone: F-T03796) cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2236
/db_xref="H-InvDB:HIT000193896"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="F-T03796"
gene 1..2236
/gene="STM-2"
CDS 368..1714
/gene="STM-2"
/codon_start=1
/protein_id="AAB59557.1"
/translation="MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENT
AQWRSQENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVV
VATIKSVRFYTEKNGQLIYTTFTEDTPSVGQRLLNSVLNTLIMISVIVVMTIFLVVLY
KYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLLLTVWNFGAVGMVC
IHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLVAVLCPKGPLRM
LVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEEDSYDSFGEP
SYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLACF
VAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI"
variation 789
/gene="STM-2"
/note="A in wt, T in patients with Alzheimer's disease
from Volga German kindreds."
/replace="t"
BASE COUNT 490 a 583 c 645 g 518 t
ORIGIN
1 cgagcggcgg cggagcaggc atttccagca gtgaggagac agccagaagc aagctattgg
61 agctgaagga acctgagaca gaagctagtc ccccctctga attttactga tgaagaaact
121 gaggccacag agctaaagtg acttttccca aggtcgccca gcgaggacgt gggacttctc
181 agacgtcagg agagtgatgt gagggagctg tgtgaccata gaaagtgacg tgttaaaaac
241 cagcgctgcc ctctttgaaa gccagggagc atcattcatt tagcctgctg agaagaagaa
301 accaagtgtc cgggattcag acctctctgc ggccccaagt gttcgtggtg cttccagagg
361 cagggctatg ctcacattca tggcctctga cagcgaggaa gaagtgtgtg atgagcggac
421 gtccctaatg tcggccgaga gccccacgcc gcgctcctgc caggagggca ggcagggccc
481 agaggatgga gagaacactg cccagtggag aagccaggag aacgaggagg acggtgagga
541 ggaccctgac cgctatgtct gtagtggggt tcccgggcgg ccgccaggcc tggaggaaga
601 gctgaccctc aaatacggag cgaagcacgt gatcatgctg tttgtgcctg tcactctgtg
661 catgatcgtg gtggtagcca ccatcaagtc tgtgcgcttc tacacagaga agaatggaca
721 gctcatctac acgacattca ctgaggacac accctcggtg ggccagcgcc tcctcaactc
781 cgtgctgaac accctcatca tgatcagcgt catcgtggtt atgaccatct tcttggtggt
841 gctctacaag taccgctgct acaagttcat ccatggctgg ttgatcatgt cttcactgat
901 gctgctgttc ctcttcacct atatctacct tggggaagtg ctcaagacct acaatgtggc
961 catggactac cccaccctct tgctgactgt ctggaacttc ggggcagtgg gcatggtgtg
1021 catccactgg aagggccctc tggtgctgca gcaggcctac ctcatcatga tcagtgcgct
1081 catggcccta gtgttcatca agtacctccc agagtggtcc gcgtgggtca tcctgggcgc
1141 catctctgtg tatgatctcg tggctgtgct gtgtcccaaa gggcctctga gaatgctggt
1201 agaaactgcc caggagagaa atgagcccat attccctgcc ctgatatact catctgccat
1261 ggtgtggacg gttggcatgg cgaagctgga cccctcctct cagggtgccc tccagctccc
1321 ctacgacccg gagatggaag aagactccta tgacagtttt ggggagcctt cataccccga
1381 agtctttgag cctcccttga ctggctaccc aggggaggag ctggaggaag aggaggaaag
1441 gggcgtgaag cttggcctcg gggacttcat cttctacagt gtgctggtgg gcaaggcggc
1501 tgccacgggc agcggggact ggaataccac gctggcctgc ttcgtggcca tcctcattgg
1561 cttgtgtctg accctcctgc tgcttgctgt gttcaagaag gcgctgcccg ccctccccat
1621 ctccatcacg ttcgggctca tcttttactt ctccacggac aacctggtgc ggccgttcat
1681 ggacaccctg gcctcccatc agctctacat ctgagggaca tggtgtgcca caggctgcaa
1741 gctgcaggga attttcattg gatgcagttg tatagtttta cactctagtg ccatatattt
1801 ttaagacttt tctttcctta aaaaataaag tacgtgttta cttggtgagg aggaggcaga
1861 accagctctt tggtgccagc tgtttcatca ccagactttg gctcccgctt tggggagcgc
1921 ctcgcttcac ggacaggaag cacagcaggt ttatccagat gaactgagaa ggtcagatta
1981 gggcggggag aagagcatcc ggcatgaggg ctgagatgcg caaagagtgt gctcgggagt
2041 ggcccctggc acctgggtgc tctggctgga gaggaaaagc cagttcccta cgaggagtgt
2101 tcccaatgct ttgtccatga tgtccttgtt attttattgc ctttagaaac tgagtcctgt
2161 tcttgttacg gcagtcacac tgctgggaag tggcttaata gtaatatcaa taaatagatg
2221 agtcctgtta gaaaaa
//