LOCUS HUMCKI 1480 bp mRNA linear HUM 14-MAY-1996
DEFINITION Homo sapiens cam kinase I mRNA, complete cds.
ACCESSION L41816
VERSION L41816.1
KEYWORDS auto inhibitory domain; calcium/calmodulin; cam kinase I; protein
kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1480)
AUTHORS Haribabu,B., Hook,S.S., Selbert,M.A., Goldstein,E.G., Tomhave,E.D.,
Edelman,A.M., Snyderman,R. and Means,A.R.
TITLE Human calcium-calmodulin dependent protein kinase I: cDNA cloning,
domain structure and activation by phosphorylation at threonine-177
by calcium-calmodulin dependent protein kinase I kinase
JOURNAL EMBO J. 14 (15), 3679-3686 (1995)
PUBMED 7641687
FEATURES Location/Qualifiers
source 1..1480
/db_xref="H-InvDB:HIT000193789"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HL-60"
/note="(vector lambda gt10)"
mRNA 1..1480
5'UTR 1..147
CDS 148..1260
/codon_start=1
/product="cam kinase I"
/protein_id="AAA99458.1"
/translation="MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQK
LVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGE
LFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMI
SDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPF
YDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI
AGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASH
GELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL"
misc_feature 1005..1110
/function="auto-inhibitory and calmodulin binding domains"
3'UTR 1261..1480
BASE COUNT 341 a 410 c 436 g 289 t
ORIGIN
1 gaattccgag caagagcgcg ggcgggtggc ccaggcacgc agcgggtgag gaccgcgccc
61 acagctcggc gccaaccacc gcgggcctcc cagccagccc cgcnnngagc cgcaggancc
121 ctggctgtgg tcggggggca gtgggccatg ctgggggcag tggaaggccc caggtggaag
181 caggcggagg acattagaga catctacgac ttccgagatg ttctgggcac gggggccttc
241 tcggaggtga tcctggcaga agataagagg acgcagaagc tggtggccat caaatgcatt
301 gccaaggagg ccctggaggg caaggaaggc agcatggaga atgagattgc tgtcctgcac
361 aagatcaagc accccaacat tgtagccctg gatgacatct atgagagtgg gggccacctc
421 tacctcatca tgcagctggt gtcgggtggg gagctctttg accgtattgt ggaaaaaggc
481 ttctacacgg agcgggacgc cagccgcctc atcttccagg tgctggatgc tgtgaaatac
541 ctgcatgacc tgggcattgt acaccgggat ctcaagccag agaatctgct gtactacagc
601 ctggatgaag actccaaaat catgatctcc gactttggcc tctccaagat ggaggacccg
661 ggcagtgtgc tctccaccgc ctgtggaact ccgggatacg tggcccctga agtcctggcc
721 cagaagccct acagcaaggc tgtggattgc tggtccatag gtgtcatcgc ctacatcttg
781 ctctgcggtt accctccctt ctatgacgag aatgatgcca aactctttga acagattttg
841 aaggccgagt acgagtttga ctctccttac tgggacgaca tctctgactc tgccaaagat
901 ttcatccggc acttgatgga gaaggaccca gagaaaagat tcacctgtga gcaggccttg
961 cagcacccat ggattgcagg agatacagct ctagataaga atatccacca gtcggtgagt
1021 gagcagatca agaagaactt tgccaagagc aagtggaagc aagccttcaa tgccacggct
1081 gtggtgcggc acatgaggaa actgcagctg ggcaccagcc aggaggggca ggggcagacg
1141 gcgagccatg gggagctgct gacaccagtg gctggggggc cggcagctgg ctgttgctgt
1201 cgagactgct gcgtggagcc gggcacagaa ctgtccccca cactgcccca ccagctctag
1261 ggccctggac ctcgggtcat gatcctctgc gtgggagggc ttgggggcca gcctgctccc
1321 cttccctccc tgaaccggga gtttctctgc cctgtcccct cctcacctgc ttccctacca
1381 ctcctcactg cattttccat acaaatgttt ctattttatt gttccttctt gtaataaagg
1441 gaagataaaa ccaaaaaaaa aaaaaaaaaa acggaattcc
//