LOCUS HUMORFC 2307 bp mRNA linear HUM 14-JUL-1995
DEFINITION Homo sapiens (clone S171) mRNA, complete cds.
ACCESSION L40393
VERSION L40393.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2307)
AUTHORS Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
Foncin,J.-F., Bruni,A.C., Montesi,M.P., Sorbl,S., Rainero,I.,
Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
Polinsky,R.J., Wasco,W., Da Silva,H.A.R., Haines,J.L.,
Pericak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
Rommens,J.M. and St. George-Hyslop,P.H.
TITLE Cloning of a gene bearing missense mutations in early-onset
familial Alzheimer's disease
JOURNAL Nature 375 (6534), 754-760 (1995)
PUBMED 7596406
COMMENT Original source text: Homo sapiens (clone: S171) (clone library:
Bento Soares) fetus brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2307
/db_xref="H-InvDB:HIT000193612"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="14q24.3"
/clone="S171"
/tissue_type="brain"
/clone_lib="Bento Soares"
/dev_stage="fetus"
/germline
mRNA <1..>2307
5'UTR <1..538
/note="putative"
CDS 539..946
/note="ORF; putative"
/codon_start=1
/protein_id="AAC42000.1"
/translation="MPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQ
TFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEA
QWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL"
3'UTR 947..>2307
/note="putative"
BASE COUNT 626 a 532 c 488 g 655 t
ORIGIN
1 agggtgcttc agtgtggctg acacagcagc atggtcttga caagttttct tcatcctacc
61 acaaaatccc agttggtaat agagacttta ctcctaccta tcaaaaccac aaaatgtccc
121 attagggggg gacatgttgt acatgttagg atcattcaaa taaccaagat tataaggtga
181 ggaaagatgc ccctaactga ttcttttgtc tctcatcttg ttggttccag ggaccgagtg
241 gggtcaatct tctggtsstg cctctccagg tctcttccag gccggtcata gacgtactcc
301 ctctgaggcc gaccgatggt tagaagaggt gtctaagagc gtccgggctc agcagcccca
361 ggcctcagct gctcctctgc agccagttct ccagcctcct ccacccactg ccatctccca
421 gccagcatca cctttccaag ggaatgcatt cctcacctct cagcctgtgc cagtgggtgt
481 ggtcccagcc ctgcaaccag cctttgtccc tgcccagtcc tatcctgtgg ccaatggaat
541 gccctatcca gcccctaatg tgcctgtggt gggcatcact ccctcccaga tggtggccaa
601 cgtwtttggc actgcaggcc accctcaggc tgcccatccc catcagtcac ccagcctggt
661 caggcagcag acattccctc actacgaggc aagcagtgct accaccagtc ccttctttaa
721 gcctcctgct cagcacctca acggttctgc agctttcaat ggtgtagatg atggcaggtt
781 ggcctcagca gacaggcata cagaggttcc tacaggcacc tgcccagtgg atccttttga
841 agcccagtgg gctgcattag aaaataagtc caagcagcgt actaatccct cccctaccaa
901 ccctttctcc agtgacttac agaagacgtt tgaaattgaa ctttaagcaa tcattatggc
961 tatgtatctt gtccatacca gacagggagc agggggtagc ggtcaaagga gcmaaacaga
1021 ytttgtctcc tgattagtac tcttttcact aatcccaaag gtcccaagga acaagtccag
1081 gcccagagta ctgtgagggg tgattttgaa agacatggga aaaagcattc ctagagaaaa
1141 gctgccttgc aattaggcta aagaagtcaa ggaaatgttg ctttctgtac tccctcttcc
1201 cttaccccct tacaaatctc tggcaacaga gaggcaaagt atctgaacaa gaatctatat
1261 tccaagcaca tttactgaaa tgtaaaacac aacaggaagc aaagcaatgt ccctttgttt
1321 ttcaggccat tcacctgcct cctgtcagta gtggcctgta ttagagatca agaagagtgg
1381 tttgtgctca ggctgggaac agagaggcac gctatgctgc cagaattccc aggagggcat
1441 atcagcaact gcccagcaga gctatatttt gggggagaag ttgagcttcc attttgagta
1501 acagaataaa tattatatat atcaaaagcc aaaatcttta tttttatgca tttagaatat
1561 tttaaatagt tctcagatat taagaagttg tatgagttgt aagtaatctt gccaaaggta
1621 aaggggctag ttgtaagaaa ttgtacatra gattgattta tcattgatgc ctactgaaat
1681 aaaaagagga aaggctggaa gcatgcagac aggatcccta gcttgttttc tgtcagtcat
1741 tcattgtaag tagcacattg caacaacaat catgcttatg accaatacag tcactaggtt
1801 gtagtttttt ttaaataaag gaaaagcagt attgtcctgg ttttaaacct atgatggaat
1861 tctaatgtca ttattttaat ggaatcaatc gaaatatgct ctatagagaa tatatctttt
1921 atatattgct gcagtttcct tatgttaatc ctttaacact aaggtaacat gacataatca
1981 taccatagaa gggaacacag gttaccatat tggtttgtaa tatgggtctt ggtgggtttt
2041 gttttatcct ttaaattttg ttcccatgag ttttgtgggg atggggattc tggttttatt
2101 agctttgtgt gtgtcctctt cccccaaacc cccttttggt gagaacatcc ccttgacagt
2161 tgcagcctct tgacctcgga taacaataag agagctcatc tcatttttac ttttgaacgt
2221 tggcgcttac aatcaaatgt aagttatata tatttgtact gatgaaaatt tataatctgc
2281 tttaacaaaa ataaatgttc atggtag
//