LOCUS HUMIMP90A 4212 bp mRNA linear HUM 05-SEP-2000
DEFINITION Homo sapiens importin beta subunit mRNA, complete cds.
ACCESSION L38951
VERSION L38951.1
KEYWORDS importin beta subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4212)
AUTHORS Gorlich,D., Kostka,S., Kraft,R., Dingwall,C., Laskey,R.A.,
Hartmann,E. and Prehn,S.
TITLE Two different subunits of importin cooperate to recognize nuclear
localization signals and bind them to the nuclear envelope
JOURNAL Curr. Biol. 5 (4), 383-392 (1995)
PUBMED 7627554
REFERENCE 2 (bases 1 to 4212)
AUTHORS Huber,J., Cronshagen,U., Kadokura,M., Marshallsay,C., Wada,T.,
Sekine,M. and Luhrmann,R.
TITLE Snurportin1, an m3G-cap-specific nuclear import receptor with a
novel domain structure
JOURNAL EMBO J. 17 (14), 4114-4126 (1998)
PUBMED 9670026
REFERENCE 3 (bases 1 to 4212)
AUTHORS Jakel,S. and Gorlich,D.
TITLE Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear
import of ribosomal proteins in mammalian cells
JOURNAL EMBO J. 17 (15), 4491-4502 (1998)
PUBMED 9687515
REFERENCE 4 (bases 1 to 4212)
AUTHORS Jakel,S., Albig,W., Kutay,U., Bischoff,F.R., Schwamborn,K.,
Doenecke,D. and Gorlich,D.
TITLE The importin beta/importin 7 heterodimer is a functional nuclear
import receptor for histone H1
JOURNAL EMBO J. 18 (9), 2411-2423 (1999)
PUBMED 10228156
COMMENT On Jul 7, 1995 this sequence version replaced gi:736680.
FEATURES Location/Qualifiers
source 1..4212
/db_xref="H-InvDB:HIT000193420"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 338..2968
/function="transports various substrates into the nucleus"
/function="may function alone or in cooperation with
specific adapter molecules (importin alpha forms,
snurportin1) or in complex with other transporters
(importin 7)"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="importin beta subunit"
/protein_id="AAC41763.1"
/translation="MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVL
ANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTE
TYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD
IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFI
MQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVA
LQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQD
ENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGC
ILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLA
PLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQ
KLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMES
HIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGV
QEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQ
SNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQ
QASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFIL
SFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTN
KAKTLATWATKELRKLKNQA"
BASE COUNT 1219 a 940 c 1032 g 1019 t
ORIGIN
1 ctccctcgct ccctccctgc gcgccgcctc tcactcacag cctcccttcc ttctttctcc
61 ctccgcctcc cgagcaccag cgcgctctga gctgccccca gggtcccctc ccccgccgcc
121 agcagcccat ttggagggag gaagtaaggg aagaggagag gaaggggagc cggaccgact
181 acccagacag agccggtgaa tgggtttgtg gtgacccccg ccccccaccc caccctccct
241 tcccacccga cccccaaccc ccatccccag ttcgagccgc cgcccgaaag gccgggccgt
301 cgtcttagga ggagtcgccg ccgccgccac ctccgccatg gagctgatca ccattctcga
361 gaagaccgtg tctcccgatc ggctggagct ggaagcggcg cagaagttcc tggagcgtgc
421 ggccgtggag aacctgccca ctttccttgt ggaactgtcc agagtgctgg caaatccagg
481 aaacagtcag gttgccagag ttgcagctgg tctacaaatc aagaactctt tgacatctaa
541 agatccagat atcaaggcac aatatcagca gaggtggctt gctattgatg ctaatgctcg
601 acgagaagtc aagaactatg ttttgcagac attgggtaca gaaacttacc ggcctagttc
661 tgcctcacag tgtgtggctg gtattgcttg tgcagagatc ccagtaaacc agtggccaga
721 actcattcct cagctggtgg ccaatgtcac aaaccccaac agcacagagc acatgaagga
781 gtcgacattg gaagccatcg gttatatttg ccaagatata gacccagagc agctacaaga
841 taaatccaat gagattctga ctgccataat ccaggggatg aggaaagaag agcctagtaa
901 taatgtgaag ctagctgcta caaatgcact cctgaactca ttggagttca ccaaagcaaa
961 ctttgataaa gagtctgaaa ggcactttat tatgcaggtg gtctgtgaag ccacacagtg
1021 tccagatacg agggtacgag tggctgcttt acagaatctg gtgaagataa tgtccttata
1081 ttatcagtac atggagacat atatgggtcc tgctcttttt gcaatcacaa tcgaagcaat
1141 gaaaagtgac attgatgagg tggctttaca agggatagaa ttctggtcca atgtctgtga
1201 tgaggaaatg gatttggcca ttgaagcttc agaggcagca gaacaaggac ggccccctga
1261 gcacaccagc aagttttatg cgaagggagc actacagtat ctggttccaa tcctcacaca
1321 gacactaact aaacaggacg aaaatgatga tgacgatgac tggaacccct gcaaagcagc
1381 aggggtgtgc ctcatgcttc tggccacctg ctgtgaagat gacattgtcc cacatgtcct
1441 ccccttcatt aaagaacaca tcaagaaccc agattggcgg taccgggatg cagcagtgat
1501 ggcttttggt tgtatcttgg aaggaccaga gcccagtcag ctcaaaccac tagttataca
1561 ggctatgccc accctaatag aattaatgaa agaccccagt gtagttgttc gagatacagc
1621 tgcatggact gtaggcagaa tttgtgagct gcttcctgaa gctgccatca atgatgtcta
1681 cttggctccc ctgctacagt gtctgattga gggtctcagt gctgaaccca gagtggcttc
1741 aaatgtgtgc tgggctttct ccagtctggc tgaagctgct tatgaagctg cagacgttgc
1801 tgatgatcag gaagaaccag ctacttactg cttatcttct tcatttgaac tcatagttca
1861 gaagctccta gagactacag acagacctga tggacaccag aacaacctga ggagttctgc
1921 atatgaatct ctgatggaaa ttgtgaaaaa cagtgccaag gattgttacc ctgctgtcca
1981 gaaaacgact ttggtcatca tggaacgact gcaacaggtt cttcagatgg agtcacatat
2041 ccagagcaca tccgatagaa tccagttcaa tgaccttcag tctttactct gtgcaactct
2101 tcagaatgtt cttcggaaag tgcaacatca agatgctttg cagatctctg atgtggttat
2161 ggcctccctg ttaaggatgt tccaaagcac agctgggtct gggggagtac aagaggatgc
2221 cctgatggca gttagcacac tggtggaagt gttgggtggt gaattcctca agtacatgga
2281 ggcctttaaa cccttcctgg gcattggatt aaaaaattat gctgaatacc aggtttgttt
2341 ggcagctgtg ggcttagtgg gagacttgtg ccgtgccctg caatccaaca tcataccttt
2401 ctgtgacgag gtgatgcagc tgcttctgga aaatttgggg aatgagaacg tccacaggtc
2461 tgtgaagccg cagattctgt cagtgtttgg tgatattgcc cttgctattg gaggagagtt
2521 taaaaaatac ttagaggttg tattgaatac tcttcagcag gcctcccaag cccaggtgga
2581 caagtcagac tatgacatgg tggattatct gaatgagcta agggaaagct gcttggaagc
2641 ctatactgga atcgtccagg gattaaaggg ggatcaggag aacgtacacc cggatgtgat
2701 gctggtacaa cccagagtag aatttattct gtctttcatt gaccacattg ctggagatga
2761 ggatcacaca gatggagtag tagcttgtgc tgctggacta ataggggact tatgtacagc
2821 atttgggaag gatgtactga aattagtaga agctaggcca atgatccatg aattgttaac
2881 tgaagggcgg agatcgaaga ctaacaaagc aaaaaccctt gctacatggg caacaaaaga
2941 actgaggaaa ctgaagaacc aagcttgatc tgttaccatt gggatgataa cctgaggacc
3001 cccactggaa atctcccatc ttttgaaaaa cctggaagtg aggagtgtgc acggatgctg
3061 aatgtttggg aatgagagga tgagtgagtg aggcttgaaa acacaccaca ttgaaaatcc
3121 tgccacagca gcagccgcag ccgccaacag cagcgctgtt agtgagctaa gtaagcactg
3181 acttcgtaga aaaccataac atcggccatc ttggaaaaga gaaaaacaat ggagttactt
3241 atttaaaaaa aaagaaagaa agttatctct tcccaggaga ggctagaagt agcttttctg
3301 tcttttggcc agtgccgagt ggaatgcctg gtttcgggga ggaggaggga ctgggttcag
3361 ctgtggtgct ttgttgtaaa aggcagcctg gcctttgcta ctgaggagaa agatggagcc
3421 tgggtctcaa gcccaccttc gctgtacctt tgccacatgg tactgtatgc ttgccagcta
3481 gaaggagggt cagggttttt tacagtctga gaatgagtgt gtgtgagtga ggcggtatcc
3541 acattctcaa cttcaagtca ttgctgtttc tttttcccag aaaacaaggg gttagatgtt
3601 gcatttcata aaactaaccg aagttctgtc tactgatgca gcacaagaga tgtaaaaaaa
3661 aaaaaaaaaa aaaaaaaaaa aaaacacaca aaaaaacaca cacacagagg aaagacgctc
3721 tttaggtttt gttttgtttt tttttttttg gttttgtttt ttgttttttt ttttactcta
3781 gggaaaacac tgacgaatgg tcagagctcc tatcctgatc ttttcatcaa ggcgcctttc
3841 ctaataatat ggttcaactg tgaatgtaga agtgggggnn aggggggaga aaaagaaaac
3901 tctggcgtta gaggatataa aaaaatataa gtacaattgt tacaaataac gcagacttca
3961 aaaacaaaaa aatcacaacc caaacaaacc aaaatttaaa tgatcagaat tggcagcaca
4021 aagaaaacgc cctctcctga cttgtattgt ggcagtctga acgcccccag aaaattgtgc
4081 caaagagttt agaaaaataa atatacaata aaagtaaaca catacacaca aaacagcaaa
4141 cttcaggtaa ctattttgga ttgcaaacag gataattaaa tgttcaaaca atctgataaa
4201 ataaccattt gg
//