LOCUS HUMITR 8662 bp mRNA linear HUM 02-APR-2004
DEFINITION Homo sapiens inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)
mRNA, complete cds.
ACCESSION L38019
VERSION L38019.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8662)
AUTHORS Harnick,D.J., Jayaraman,T., Ma,Y., Mulieri,P., Go,L.O. and
Marks,A.R.
TITLE The human type 1 inositol 1,4,5-trisphosphate receptor from T
lymphocytes. Structure, localization, and tyrosine phosphorylation
JOURNAL J. Biol. Chem. 270 (6), 2833-2840 (1995)
PUBMED 7852357
REFERENCE 2 (bases 1 to 8662)
AUTHORS Marks,A.
TITLE Direct Submission
JOURNAL Submitted (01-DEC-1994) Physiology, Columbia University, 630 W
168th Street, New York, NY 10032, USA
REFERENCE 3 (bases 1 to 8662)
AUTHORS Marks,A.
TITLE Direct Submission
JOURNAL Submitted (02-APR-2004) Physiology, Columbia University, 630 W
168th Street, New York, NY 10032, USA
REMARK Sequence update by submitter
COMMENT On Apr 2, 2004 this sequence version replaced L38019.1.
FEATURES Location/Qualifiers
source 1..8662
/db_xref="H-InvDB:HIT000193359"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3p"
/clone="HUM-IP3R1"
/cell_line="Jurkat"
/cell_type="T lymphocyte"
/tissue_type="T lymphocyte"
/dev_stage="adult"
gene 1..8662
/gene="ITPR1"
CDS 248..8380
/gene="ITPR1"
/codon_start=1
/product="inositol 1,4,5-trisphosphate receptor type 1"
/protein_id="AAB04947.2"
/db_xref="GDB:G00-127-552"
/translation="MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETG
DLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQ
NETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSW
FYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSW
KIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSAT
SSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVD
PDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRH
LCTNTWVHSTNIPIDKEEEKPVMLKIGTSPVKEDKEAFAIVPVSPAEVRDLDFANDAS
KVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQK
LMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQD
YRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRK
NREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSS
TGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDVLSYYRYQLNL
FARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQ
VTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFVEEYLRDVVCQRFPFS
DKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMAKGE
ENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTK
LKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQEGPSNVPGALD
FEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHF
SQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDETMDG
ASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQR
LLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINL
FLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE
GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHL
VELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEV
EMKEIYTSNHMWKLFENFLVDICRACNNTXDRKHADSILEKYVTEIVMSIVTTFFSSP
FSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIP
VDLDSQVNNLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSA
LEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENE
EKLCIKVLQTLREMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLS
AGGPGKPGGGGGGSGSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHES
ILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDL
GNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHY
QPGEGTQATADKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYN
LVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIA
THESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILY
NMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQS
MLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYT
TERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMN
LLVAFLYPLKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIF
SVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLVICAM
GLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLF
FKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSPAPREELVPAEET
EQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVI
IIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERXKFDNKTVTFEEHIKEEH
NMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRAMSLVSSDSEGEQNE
LRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA"
BASE COUNT 2403 a 2025 c 2225 g 2006 t
ORIGIN
1 cgggagagaa agcgcacgcc gagaggaggt gtgggtgttc cgcttccatc ctaacggaac
61 gagctccctc ttcgcggaca tgggattacc cagcggctgc taacccctct cctcgccctg
121 ctcccccaaa ccggcgtggc tccccgggca ccaaggagct gactacagag gagcaggatt
181 tgcacccctc gctgggcttg ctttggcaac agagtgcctg acccaggtca ggattttcaa
241 gaaagacatg tctgacaaaa tgtctagctt cctacatatt ggagacattt gttctctgta
301 cgcggaggga tcgacaaatg gatttattag caccttgggc ctggttgatg atcgttgtgt
361 tgtacagcca gaaaccgggg accttaacaa tccacctaag aaattcagag actgcctctt
421 taagctatgt cccatgaacc gctactctgc ccaaaagcag ttctggaaag ccgctaagcc
481 tggggccaac agcaccacag acgcagtgct actcaacaaa ctgcaccacg ctgcagactt
541 ggaaaagaag cagaatgaga cagaaaacag gaaattgctg gggaccgtaa tccagtatgg
601 caatgtgatc cagctcctgc atttgaaaag taataaatac ctaacagtga ataagaggct
661 tcctgctctg ttggagaaga atgccatgag agtcacattg gacgaggctg gaaatgaagg
721 gtcctggttt tatattcagc cattctacaa gctgcgatcc attggagaca gcgtggtcat
781 aggtgacaag gtggttctga accccgtcaa tgctggtcag cccctacatg ctagcagcca
841 tcaactggta gataacccag gctgcaatga ggtcaattcc gtcaactgca atacaagctg
901 gaaaatagtc cttttcatga aatggagtga taacaaagac gacatattaa aggggggtga
961 cgtggtgagg ctgtttcatg ctgagcagga gaagtttctc acctgtgacg aacacaggaa
1021 gaagcagcac gtcttcctga gaaccacggg ccggcagtcg gccacatctg ccaccagttc
1081 aaaagccctg tgggaggtgg aggtggtcca gcatgaccca tgtcggggcg gagcagggta
1141 ttggaacagc cttttccgtt tcaagcatct ggccacgggg cattacttgg cagcagaggt
1201 agaccctgac tttgaggaag aatgcctgga gtttcagccc tcagtggacc ctgatcagga
1261 cgcctctcga agtaggttgc ggaatgccca agaaaagatg gtatactccc tggtctctgt
1321 gcctgaaggc aatgacatct cctccatttt cgagctagat cccaccactc tgcgtggagg
1381 tgacagcctt gtcccaagga actcttatgt tcggctcaga cacctatgta ctaatacctg
1441 ggttcacagc acaaatattc ctattgacaa ggaagaagaa aagcccgtga tgctgaaaat
1501 tggcacctct cctgtgaagg aggataagga agcatttgcc atagttccgg tttctcctgc
1561 tgaagttcgg gacctggact ttgccaatga tgccagcaag gtgctgggct ccattgctgg
1621 gaagctagag aagggcacca tcacccagaa tgaaaggagg tctgtaacca agctgctaga
1681 agatttggtt tacttcgtca ctggtggaac taattctggt caagatgttc tcgaagttgt
1741 cttctccaag cccaacagag aacggcagaa actgatgaga gaacagaata ttctcaagca
1801 gatcttcaag ttgttacaag ccccattcac agactgcggt gatggcccaa tgcttcggct
1861 ggaagagctc ggggaccagc ggcacgctcc tttcagacac atctgccggc tctgctacag
1921 ggtgctgaga cactcgcagc aagactacag gaagaaccag gagtatatag ccaagcagtt
1981 tggcttcatg cagaagcaga ttggctatga tgtgttggct gaagacacta tcactgccct
2041 gctccacaat aatcggaaac tcctggaaaa acacattacc gcggcagaga ttgacacatt
2101 tgtcagcctg gtgcgaaaga acagggagcc cagattctta gattacctct ccgacctctg
2161 tgtctccatg aacaaatcaa ttccagtgac ccaggaactg atatgtaaag ctgtgctgaa
2221 ccccaccaac gctgacatcc tgattgagac caaattggtt ctttctcgtt ttgaatttga
2281 aggtgtctct tccactggag agaatgctct ggaggcagga gaagacgagg aagaggtgtg
2341 gctgttttgg agggacagca acaaagagat tcgcagcaag agtgtgaggg aattggctca
2401 ggatgctaaa gaagggcaga aggaggaccg agacgttctc agctactaca gatatcagct
2461 gaacctcttt gcgaggatgt gtctggaccg ccaatacctg gccatcaacg aaatctcagg
2521 ccagctggat gtcgatctca ttctccgctg catgtctgac gagaacctgc cctatgacct
2581 cagggcgtcc ttctgccgcc tcatgcttca catgcatgtg gaccgagatc cccaggaaca
2641 agtcaccccc gtgaaatatg cccgcctctg gtcggagatt ccctcggaga tcgccattga
2701 cgactatgat agtagtggag cttccaaaga tgaaattaag gagagatttg ctcagaccat
2761 ggagtttgtg gaggagtatt taagagatgt ggtttgtcag aggttccctt tctctgataa
2821 agagaagaat aagcttacgt ttgaggttgt aaatttagct aggaatctca tatactttgg
2881 tttctacaac ttctctgacc ttctacgatt aactaagatc cttctggcca tattggactg
2941 tgtacatgtg acaacaatct tccccattag caagatggcg aaaggagaag agaataaagg
3001 cagtaacgtg atgagatcta ttcatggcgt gggagagctg atgacccagg tggtgctccg
3061 gggaggaggc tttttgccca tgactcccat ggctgctgcc cctgaaggca atgtgaagca
3121 ggcagagcct gagaaggagg acatcatggt catggacacc aagctgaaga tcattgagat
3181 actccagttt attttgaatg tgaggttgga ttataggatc tcctgcctcc tgtgtatatt
3241 taagcgagag tttgatgaaa gcaattccca gacttcagaa acatcctccg gaaacagcag
3301 ccaagaaggg ccaagtaatg taccaggtgc tcttgacttt gaacacattg aagaacaagc
3361 agaaggcatc tttggaggaa gtgaggagaa caccccactg gacttggatg accacggcgg
3421 cagaaccttt ctccgtgtcc tgctccactt gacgatgcat gactacccac ccctggtgtc
3481 aggggccctg cagctcctct tccggcactt cagccagagg caggaggtgc tccaggcctt
3541 caaacaggtt caactgctgg ttaccagcca agatgtggac aactacaaac agatcaaaca
3601 agacttggat caactgaggt ccatcgtgga aaagtcagag ctttgggtgt acaaagggca
3661 gggccccgat gagactatgg atggtgcatc tggagaaaat gaacataaga aaacggagga
3721 gggaaataac aagccacaaa agcatgaaag caccagcagc tacaactaca gagtggtcaa
3781 agagattttg attcggctta gcaaactctg tgttcaagag agtgcctcag tgagaaagag
3841 caggaagcag caacagcgtc tgctccggaa catgggcgcg cacgccgtgg tgctggagct
3901 gctgcagatt ccctatgaga aggccgaaga taccaagatg caagagataa tgaggttggc
3961 tcatgaattt ttgcagaatt tctgcgcagg caaccagcag aatcaagctt tgctacataa
4021 acacataaac ctgtttctca acccagggat cctggaggca gtaaccatgc agcacatctt
4081 catgaacaat ttccagcttt gcagtgagat caacgagaga gttgttcagc acttcgttca
4141 ctgcatagag actcacggtc ggaatgtcca gtatataaag ttcttacaga caattgtcaa
4201 ggcagaaggg aaatttatta aaaaatgcca agacatggtt atggccgagc tggtcaattc
4261 gggagaggat gtcctcgtgt tctacaacga cagagcctct ttccagactc tgatccagat
4321 gatgcggtca gaacgggatc ggatggatga gaacagccct ctcatgtacc acatccactt
4381 ggtcgagctc ctggctgtgt gcacggaggg taagaatgtc tacacagaga tcaagtgcaa
4441 ctccctgctc ccgctggatg acatcgttcg cgttgtgacc cacgaggact gcatccctga
4501 ggttaaaatt gcatacatta acttcctgaa tcactgctat gtggatacag aggtggaaat
4561 gaaggagatt tataccagca atcacatgtg gaaattgttt gagaatttcc ttgtagacat
4621 ctgcagggcc tgtaacaaca ctantgacag gaaacatgca gactcgattt tggagaagta
4681 tgtcaccgaa atcgtcatga gtattgttac tactttcttc agctctccct tctcagacca
4741 gagtacgact ttgcagactc gccagcctgt ctttgtgcaa ctgctgcaag gcgtgttcag
4801 ggtttaccac tgcaactggt taatgccaag ccaaaaagcc tccgtggaga gctgtattcg
4861 ggtgctgtct gatgtagcca agagccgggc cattgccatt cccgtggacc tggacagcca
4921 agtcaacaac ctctttctca agtcccacag cattgtgcag aaaacagcca tgaactggcg
4981 gctctcagcc cgcaatgccg cacgcaggga ctctgttctg gcagcttcca gagactaccg
5041 gaatatcatt gagagattgc aggacatcgt ctccgcgctg gaggaccgtc tcaggcccct
5101 ggtgcaggca gagttatctg tgctcgtgga tgttctccac agacccgagc tgcttttccc
5161 agagaacaca gacgccagaa ggaaatgtga aagtggcggt ttcatttgca agttaataaa
5221 gcatacaaaa cagctgctag aagaaaatga agagaagctc tgcattaagg tcctacagac
5281 cctgagggaa atgatgacca aagatagagg ctatggagaa aagggtgagg cgctcaggca
5341 agttctggtc aaccgttact atggaaacgt cagaccttcg ggacgaagag agagccttac
5401 cagctttggc aatggcccac tgtcagcagg aggacccggc aagcccgggg gaggaggggg
5461 aggttccgga tccagctcta tgagcagggg tgagatgagt ctggccgagg ttcagtgtca
5521 ccttgacaag gagggggctt ccaatctagt tatcgacctc atcatgaacg catccagtga
5581 ccgagtgttc catgaaagca ttctcctggc cattgccctt ctggaaggag gcaacaccac
5641 catccagcac tcctttttct gtcgcttgac agaagataag aagtcagaga aattctttaa
5701 ggtgttttat gaccggatga aggtggccca gcaagaaatc aaagcaacag tgacagtgaa
5761 caccagtgac ttgggaaata aaaagaaaga cgatgaggta gacagggatg ccccatcacg
5821 gaaaaaagct aaagagccca caacacagat aacagaagag gtccgggatc agctcctgga
5881 ggcctccgct gccaccagga aagccttcac cactttcagg agggaggctg atcccgacga
5941 ccactaccag cctggagagg gcacccaggc cactgccgac aaggccaagg acgacctgga
6001 gatgagcgcg gtcatcacca tcatgcagcc catcctccgc ttccttcagc tcctgtgtga
6061 aaaccacaac cgagacctgc agaacttcct ccgttgccaa aataacaaga ccaactacaa
6121 tttggtatgt gagaccctgc agtttctgga ctgtatttgt ggaagcacaa ctggaggcct
6181 tggtcttctg ggcttgtata taaatgaaaa gaacgtagcg cttatcaacc aaaccctgga
6241 aagtctgacc gaatactgtc aaggaccttg ccatgagaac cagaactgca tagccaccca
6301 tgaatccaat ggcattgaca tcatcacagc cctgatcctc aatgatatca atcctttggg
6361 aaagaagagg atggaccttg tgttagaact gaagaacaat gcctcgaagt tgctcctggc
6421 catcatggaa agcaggcacg acagtgaaaa cgcagagagg atactttata acatgaggcc
6481 caaggaactg gtggaagtga tcaagaaagc ctacatgcaa ggtgaagtgg aatttgagga
6541 tggagaaaac ggtgaggatg gggcggcgtc ccccaggaac gtggggcaca acatctacat
6601 attagcccat cagttggctc ggcataacaa agaacttcag agcatgctga aacctggtgg
6661 ccaagtggac ggagatgaag ccctggagtt ttatgccaag cacacggcgc agatagagat
6721 tgtcagatta gaccgaacaa tggaacagat agtctttccc gtgcccagca tatgtgaatt
6781 cctaaccaag gagtcaaaac tacgaattta ctatactaca gagagagacg aacaaggcag
6841 caaaatcaat gatttctttc tgcggtctga agacctcttc aatgaaatga attggcagaa
6901 gaaactgaga gcccagcccg tgttgtactg gtgtgcccgc aacatgtctt tctggagcag
6961 catttcgttt aacctggccg tcctgatgaa cctgctggtg gcgtttctct acccgcttaa
7021 gggagtccga ggaggaaccc tggagcccca ctggtcggga ctcctgtgga cagccatgct
7081 catctccctg gccatcgtca ttgccctccc caagccccat ggcatccggg ccttaattgc
7141 ctccacaatt ctacgactga tattttcagt cgggttacaa cccacgttgt ttcttctggg
7201 cgctttcaat gtatgcaata aaatcatctt tctaatgagc tttgtgggca actgtgggac
7261 attcacaaga ggctaccgag ccatggttct ggatgttgag ttcctctatc atttgttgta
7321 tctggtgatc tgtgccatgg ggctctttgt ccatgaattc ttctacagtc tgctgctttt
7381 tgatttagtg tacagagaag agactttgct taatgtcatt aaaagtgtca ctcgcaatgg
7441 acggtccatc atcctgacag cagttctggc tctgatcctc gtttacctgt tctcaatagt
7501 gggctatctt ttcttcaagg atgactttat cttggaagta gataggctgc ccaatgaaac
7561 agctgttcca gaaaccggcg agagtttggc aagcgagttc ctgttctccg atgtgtgtag
7621 ggtggagagt ggggagaact gctcctctcc tgcacccaga gaagagctgg tccctgcaga
7681 agagacggaa caggataaag agcacacatg tgagacgctg ctgatgtgca ttgtcactgt
7741 gctgagtcac gggctgcgga gcgggggtgg agtaggagat gtactcagga agccgtccaa
7801 agaggaaccc ctgtttgctg ctagagttat ttatgacctc ttgttcttct tcatggtcat
7861 catcattgtt cttaacctga tttttggggt tatcattgac acttttgctg acctgaggag
7921 tgagaagcag aagaaggaag agatcttgaa gaccacntgc tttatctgtg gcttggaaag
7981 anacaagttt gacaacaaga ctgtcacctt tgaagagcac atcaaggaag aacacaacat
8041 gtggcactat ctgtgcttca tcgtcctggt gaaagtaaag gactccaccg aatatactgg
8101 gcctgagagt tacgtggcag aaatgatcaa ggaaagaaac cttgactggt tccccaggat
8161 gagagccatg tcattggtca gcagtgattc tgaaggagaa cagaatgagc tgagaaacct
8221 gcaggagaag ctggagtcca ccatgaaact tgtcacgaac ctttctggcc agctgtcgga
8281 attaaaggat cagatgacag aacaaaggaa gcagaaacaa agaattggtc ttctaggaca
8341 tcctcctcac atgaatgtca acccacaaca accagcataa gcaaatgaaa gaaaggaatt
8401 gtatttacct tttataatta ttattagtgt gggtatggct aatgagttct gattcaccca
8461 cgaaggttac atttatgctg aatacatttg taaatactca gttttatact gtatgtatat
8521 gattgctact ctaaaggttt ggatatatgt attgtaatta gaattgttgg catgatgaca
8581 tttcatttgt gccaaaaata ttaaaaatgc cttttttgga aggactaaca gaaagcacct
8641 gatttgcact tgaaccagtc cg
//