LOCUS AH006463 8525 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 5 lamin B1 gene, complete cds.
ACCESSION AH006463 AF003956 L37737 L37738 L37739 L37740 L37741 L37742 L37743
L37744 L37745 L37746 L37747
VERSION AH006463.3
KEYWORDS lamin B1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8525)
AUTHORS Lin,F. and Worman,H.J.
TITLE Structural organization of the human gene (LMNB1) encoding nuclear
lamin B1
JOURNAL Genomics 27 (2), 230-236 (1995)
PUBMED 7557986
REFERENCE 2 (bases 1 to 8525)
AUTHORS Lin,F. and Worman,H.J.
TITLE Expression of nuclear lamins in human tissues and cancer cell lines
and transcription from the promoters of the lamin A/C and B1 genes
JOURNAL Exp. Cell Res. 236 (2), 378-384 (1997)
PUBMED 9367621
REFERENCE 3 (bases 1 to 8525)
AUTHORS Worman,W.J.
TITLE Direct Submission
JOURNAL Submitted (28-NOV-1994) Medicine, Columbia University, 630 West
168th Street, New York, NY 10032, USA
REFERENCE 4 (bases 1 to 8525)
AUTHORS Worman,W.J.
TITLE Direct Submission
JOURNAL Submitted (13-MAY-1997) Medicine, Columbia University, 630 West
168th Street, New York, NY 10032, USA
REMARK Sequence update by submitter
COMMENT On or before Jun 10, 2016 this sequence version replaced L37737.2,
L37738.1, L37739.1, L37740.1, L37741.1, L37742.1, L37743.1,
L37744.1, L37745.1, L37746.1, L37747.1, AH006463.2.
FEATURES Location/Qualifiers
source 1..8525
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q23.2-31.3"
exon <1337..2035
/number=1
5'UTR <1337..1676
mRNA join(<1677..2035,2666..2822,3421..3546,4133..4303,
4629..4754,5055..5275,5707..5932,6252..6356,6778..6897,
7280..7387,7724..8513)
/product="lamin B1"
CDS join(1677..2035,2666..2822,3421..3546,4133..4303,
4629..4754,5055..5275,5707..5932,6252..6356,6778..6897,
7280..7387,7724..7765)
/codon_start=1
/product="lamin B1"
/protein_id="AAC37575.1"
/translation="MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLA
VYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAK
LQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLE
GDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINE
TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENAR
LSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLLAKEKDN
SRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSP
SPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVD
GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTIWAANAGVTAS
PPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEAAGVVVE
EELFHQQGTPRASNRSCAIM"
gap 2088..2187
/estimated_length=unknown
exon 2666..2822
/number=2
gap 3022..3121
/estimated_length=unknown
exon 3421..3546
/number=3
gap 3786..3885
/estimated_length=unknown
exon 4133..4303
/number=4
gap 4507..4606
/estimated_length=unknown
exon 4629..4754
/number=5
gap 4853..4952
/estimated_length=unknown
exon 5055..5275
/number=6
gap 5530..5629
/estimated_length=unknown
exon 5707..5932
/number=7
gap 5948..6047
/estimated_length=unknown
exon 6252..6356
/number=8
gap 6571..6670
/estimated_length=unknown
exon 6778..6897
/number=9
gap 7057..7156
/estimated_length=unknown
exon 7280..7387
/number=10
gap 7468..7567
/estimated_length=unknown
exon 7724..8513
/number=11
3'UTR 7766..8513
regulatory 8497..8502
/regulatory_class="polyA_signal_sequence"
BASE COUNT 2041 a 1517 c 1734 g 2233 t
ORIGIN
1 ctcagccttc caagtaggtg agattacagg cacccgccat catgcccggc taatttttgt
61 atttttgtag agacggggtt tcaccagttg gtcaggctgg tttgaactcc tgagctcagg
121 tgatcctccc ccatcggcct cccaaagtgt tgggattata ggcgtgagcc accgcgcccc
181 gcccggatga attttcaaat agaaacaatc cagtttccca catcacacgg agattgtgtg
241 gatgggtaat ccatgaaaag cctggtgctg gcactcagtc ccaataaatg ttagctaaaa
301 attaggaact tttcaaaggg atgaatgtgc tttctaatag aagtagctgc cagtgacatc
361 ttgggagcct ctttttaaaa gcaaaaaatt atttcatctt aaattttcac aagttcagat
421 ttttatgtac ctgattttaa cggagtatga aacagcttgc tctcgtagtt actcaccgtc
481 atatgttaat cgtatcattt ctgagctgtt ttttgatttt acaaacccta aattaagaaa
541 cggattagga accgcccatt aacactgttg gcaaatgatt taaaatcagg gttgctggtt
601 tttcgtgata atctatcggc ttcaagacgc acagatctca atttcatgga aagaagttgc
661 ctgatacagt tttccaccgg agagaaaaat aaaggctggt acttggaacc tgcaagccgt
721 gcatttggaa cctcggactc aagtgcctat tacgtaattc cacagcgtcc cggcctccag
781 gccgtttccc gagccctcca gcggagcggg ggataaggtt accacgcccg cggtggccgg
841 ggacactctg agtttcgcgt gtggctttta gggacgttta tatttgaatt tccctgaacc
901 gccgagtgtg ggcggtggcg cagatccgtc ccggaaacct ccggggtcct tcccgccttt
961 ttcaggcccg gcccctccaa ggggtccgcg gggcggcggg agggccctgg gcccagaacc
1021 gcgcgggtgg gcagtcccag gcgtccttcc ttacagccct gagcctggtc cgggaacttc
1081 cagccgggag ggccgagctg acggttcgca agggccagat tttaaattta caggcccggc
1141 ccccgaacgc cgaagcgcgc tgcctgctcc ccattggccc atggtagtca cgtggaggac
1201 cggggagtgc cggccatgtt ggggagtgcg gcgcgggccc gcgccacctc gccccccgcg
1261 gcttgcctcc agcctgacct cccggccctc ctccccgccg cccgccgctc cgtgcagcct
1321 gagaggaaac aaagtgctgc gagcaggaga cggcggcggc gcgaaccctg ctgggcctcc
1381 agtcaccctc gtcttgcatt ttcccgcgtg cgtgtgtgag tgggtgtgtg tgttttctta
1441 caaaggtatt cgcgatcgat cgattgattc gtagttcccc cccgcgcgcc tttgcccttt
1501 gtgctgtaat cgagctcccg ccatcccagg tgcttctccg ttcctctaaa cgccagcgtc
1561 tggacgtgag cgcaggtcgc cggtttgtgc cttcggtccc cgttcgcccc ctgccgtccc
1621 ctccttatca cggtcccgct cgcggcctcg ccgccccgct gtctccgccg cccgccatgg
1681 cgactgcgac ccccgtgccg ccgcggatgg gcagccgcgc tggcggcccc accacgccgc
1741 tgagccccac gcgcctgtcg cggctccagg agaaggagga gctgcgcgag ctcaatgacc
1801 ggctggcggt gtacatcgac aaggtgcgca gcctggagac ggagaacagc gcgctgcagc
1861 tgcaggtgac ggagcgcgag gaggtgcgcg gccgtgagct caccggcctc aaggcgctct
1921 acgagaccga gctggccgac gcgcgacgcg cgctcgacga cacggcccgc gagcgcgcca
1981 agctgcagat cgagctgggc aagtgcaagg cggaacacga ccagctgctc ctcaagtgag
2041 tgctagctgg cggccgcgtt agccaaggag gggcgggggc gcaaccgnnn nnnnnnnnnn
2101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2161 nnnnnnnnnn nnnnnnnnnn nnnnnnngaa ttcctggtct caagtgatcc tcccacatca
2221 gcctctcaaa gtgatgtgat tacagacgta agccactgcg ctcagcatga tatcctgact
2281 tacagttcct gtatgttttg gcttataata tgcattatat ttaaaaaatg aattttcatt
2341 tcttcaaaaa tatcctgtgt tagtgtgcct ctttatagaa caagggggac atgcagtctc
2401 actcaaggac aagcaggatt ctggtacatt ggtctttaat atggacgtct ttgacccata
2461 gttattagta atcatgtgac attgaaagag aatgttagcc aacaaaaact ctagatccag
2521 tgcttgtgaa ttgcttctct aattttgata ggtgatggga gcctttattt aaactacttc
2581 ttttgtttgt cccttcagca gagagggaga agacctcaag tcatcagtat ggtttgatgt
2641 cttatgcttt ttaaatctgt tccagctatg ctaagaagga atctgatctt aatggcgccc
2701 agatcaagct tcgagaatat gaagcagcac tgaattcgaa agatgcagct cttgctactg
2761 cacttggtga caaaaaaagt ttagagggag atttggagga tctgaaggat cagattgccc
2821 aggtaaggtc aagcctactc ttgagcgtat gtgacaggtt aattgcctca tctgccttaa
2881 gccatagttt gattgattga ttgattttca aatgtatttt atttttgaaa ttttatatat
2941 ttcgttttct gatggtttac ttgaagaaaa gtcttgaggt agctaacatg caaacattat
3001 cacctccagc atatatctga tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3121 naaaatgaag tggttagcta aaataactag tttgcatttt gaaatgtgag tgagtcatac
3181 gtctctgttc tattccctgt tgccaattaa caatttgact ggtcgtttgg tatgatactc
3241 tgtgggtggg accagcaaat gaatacccag ttctgtgata aatgttaaga tgaagtaatt
3301 atacattgat aaatatatag gaattttaac acttgatttg atttgattca tagatatctt
3361 atgttcatta ttaaatgatt gccatgtaat ttttatcaca attctttttc cttgtaatag
3421 ttggaagcct ccttagctgc agccaaaaaa cagttagcag atgaaacttt acttaaagta
3481 gatttggaga atcgttgtca gagccttact gaggacttgg agtttcgcaa aagcatgtat
3541 gaagaggtaa ctatatataa ttttgctttg taaaggaatg gaggggttct agaatgactt
3601 tgtcatagct aaacatgtaa ttatatttta tttatgattt ctttaccaca aaaatatatc
3661 agataaagaa taataaggtt tggggatggg gagaatttgc aggtagatta ttcaagctac
3721 tcgtgctaaa agaccgcatt tgagaactca agctgttacc gtaacagata tgattcactc
3781 actacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnaatag ctagtctcct
3901 gaaaggaata gaagttccta aggcttgaga tgctaccact tctgtcatta gttccatttc
3961 aaaaacctca actgaaaact aagaggcaaa aaagtgttta ttcacatgac cgcctgagga
4021 caaacaggag gaagttcgtg tgtaaaactt cagatggctg tgatgtcact cagatgtgta
4081 ccaatgcagc catggtaagt agcttggctt tatgcttttg ttttttcccc aggagattaa
4141 cgagaccaga aggaagcatg aaacgcgctt ggtagaggtg gattctgggc gtcaaattga
4201 gtatgagtac aagctggcgc aagcccttca tgagatgaga gagcaacatg atgcccaagt
4261 gaggctgtat aaggaggagc tggagcagac ttaccatgcc aaagtgagct tctcttcaga
4321 agattctttt gaacacttaa aatcattact tcacaattcc catgatgaac atggctttat
4381 tgtttatttt gttctagttt taaaaatgat tcccctagtc tccatgaaat atatagaaaa
4441 ttgatttttc aaaagtgcgt ttctataact aatgtataaa atactagaga tgtaggtgtg
4501 cattatnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntatg ctttgcttct
4621 tcttttagct tgagaatgcc agactgtcat cagagatgaa tacttctact gtcaacagtg
4681 ccagggaaga actgatggaa agccgcatga gaattgagag cctttcatcc cagctttcta
4741 atctacagaa agaggtaaat aatcatcttt ctgtaagaag ttagacttga aggctacctt
4801 caccagggca cctacctgct ttgcttgggc tgatgtcact ctcctctgtt gtnnnnnnnn
4861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnagagatca taggtgtact gtttccagtc
4981 tagaatgatt aaatagctgc ctggtgctaa tgttggaatg ttcctagaaa gtaatatgtt
5041 ccttcgatct taagtctaga gcatgtttgg aaaggattca agaattagag gacttgcttg
5101 ctaaagaaaa agacaactct cgtcgcatgc tgacagacaa agagagagag atggcggaaa
5161 taagggatca aatgcagcaa cagctgaatg actatgaaca gcttcttgat gtaaagttag
5221 ccctggacat ggaaatcagt gcttacagga aactcttaga aggcgaagaa gagaggtaag
5281 gaacttaagg gtcaccctac cttatggtcc actttttgcc tctcaccctt tttattgaaa
5341 taaaaataaa tagcatttta aaaagaactt tattttcttg gtcatttctt tgaacaccta
5401 ggtatagaag tagtaataga tcatatttct acctcatcgc agaaaatgct tgctcaagta
5461 ctcttagttt atttattatt attactttaa tgctgaactg cagcaggatg gattagttcc
5521 ttcgagattn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ttttttgttt
5641 tttttttttt aaggcgagaa gggcatatgt gttttaaaaa tgaattgttt tatttttccc
5701 atataggttg aagctctctc caagcccttc ttcccgtgtg acagtatccc gagcatcctc
5761 aagtcgtagt gtacgtacaa ctagaggaaa gcggaagagg gttgatgtgg aagaatcaga
5821 ggcgagtagt agtgttagca tctctcattc cgcctcagcc actggaaatg tttgcatcga
5881 agaaattgat gttgatggga aatttatccg cttgaagaac acttctgaac aggtataaat
5941 gacctttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnctt actaattaac
6061 tcattgttga agttactgtt gacaaaatga cagaatcgtg ttttcttttt atagtaggaa
6121 aacctgaaat gtgggaagat gaccataaag cggtcttagt ttaactgcct gtatggactt
6181 aatttatttg attattccac aactttcttt atctttgaag taacacccct caccctcctt
6241 tctgtgtgta ggatcaacca atgggaggct gggagatgat cagaaaaatt ggagacacat
6301 cagtcagtta taaatatacc tcaagatatg tgctgaaggc aggccagact gttacagtaa
6361 gtgaatctag tcatcattta atttaacttc attgtgttaa ctaacaaagt aactcaaaaa
6421 gttttttggc taaaagagaa gcattttaga aatggccgtt aaagtacttt ttattatata
6481 gggcattaca agtgctataa agatttttaa attctgtctt attgagagta gtgaaggaat
6541 ggaccttgaa ttatttatct tgtctatcca nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6661 nnnnnnnnnn agttctcaga cttttagaat caagtgtttg agtctcatcg cattgctgtc
6721 gttggcatgt gggagaactg ggttctgggt gtactgacat gctttggttt tttacagatt
6781 tgggctgcaa acgctggtgt cacagccagc cccccaactg acctcatctg gaagaaccag
6841 aactcgtggg gcactggcga agatgtgaag gttatattga aaaattctca gggagaggta
6901 tggccagttt atcaggacca ccacaatgtt aatttcactt aaagaacact gtgcaagtat
6961 aatcaagatc agattgaaac gtgcaataac cgattcgata aacagaccaa gctcgtagtt
7021 attgaactga agctgtctta gtttaggata ataggannnn nnnnnnnnnn nnnnnnnnnn
7081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7141 nnnnnnnnnn nnnnnnatta caggtgtgag ccactgcgcc tggcaagaaa tgctgtctct
7201 taagcaaaga aaaggtccct ctcccccgca tttggtgatt ttaagtgtgt tttttaactt
7261 aaactactat tgtttttagg aggttgctca aagaagtaca gtctttaaaa caaccatacc
7321 tgaagaagag gaggaggagg aagaagcagc tggagtggtt gttgaggaag aacttttcca
7381 ccagcaggta ttactttatt tatttaatat atttatttca aattttattc acagaattac
7441 atgaagacca agagtgtggt tgggtttnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7561 nnnnnnnaaa agaaaaggtt agaaagatga gagatgataa agggtccatt tgaggttagg
7621 taatatggtt tggtatccct gtagttaaaa gtttttgtct tattttagaa tactgtgatc
7681 tatttcttta gtattaattt ttccttctgt tttcctcatc tagggaaccc caagagcatc
7741 caatagaagc tgtgcaatta tgtaaaattt tcaactgtct tcctcaaaat aaagaagtat
7801 ggtaatcttt acctgtatac agtgcagagc cttctcagaa gcacagaata tttttatatt
7861 tcctttatgt gaatttttaa gctgcaaatc tgatggcctt aatttccttt ttgacactga
7921 aagttttgta aaagaaatca tgtccataca ctttgttgca agatgtgaat tattgacact
7981 gaacttaata actgtgtact gttcggaagg ggttcctcaa attttttgac tttttttgta
8041 tgtgtgtttt ttcttttttt ttaagttctt atgaggaggg gagggtaaat aaaccactgt
8101 gcgtcttggt gtaatttgaa gattgcccca tctagactag caatctcttc attattctct
8161 gctatatata aaacggtgct gtgagggagg ggaaaagcat ttttcaatat attgaacttt
8221 tgtactgaat ttttttgtaa taagcaatca aggttataat tttttttaaa atagaaattt
8281 tgtaagaagg caatattaac ctaatcacca tgtaagcact ctggatgatg gattccacaa
8341 aacttggttt tatggttact tcttctctta gattcttaat tcatgaggag ggtgggggag
8401 ggaggtggag ggagggaagg gtttctctat taaaatgcat tcgttgtgtt ttttaagata
8461 gtgtaacttg cttaaatttc ttatgtgaca ttaacaaata aaaaagctct tttaatatta
8521 gataa
//