LOCUS HUMRETCG 3723 bp mRNA linear HUM 17-AUG-1995
DEFINITION Homo sapiens guanylyl cyclase (RetGC-2) mRNA, complete cds.
ACCESSION L37378
VERSION L37378.1
KEYWORDS guanylyl cyclase; photoreceptor-specific membrane protein;
transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3723)
AUTHORS Lowe,D.G., Dizhoor,A.M., Liu,K., Gu,Q., Spencer,M., Laura,R., Lu,L.
and Hurley,J.B.
TITLE Cloning and expression of a second photoreceptor-specific membrane
retina guanylyl cyclase (RetGC), RetGC-2
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5535-5539 (1995)
PUBMED 7777544
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3723
/db_xref="H-InvDB:HIT000193306"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="cloning vector: lambda gt10"
gene 1..3723
/gene="RetGC-2"
mRNA 1..3723
/gene="RetGC-2"
CDS 300..3626
/gene="RetGC-2"
/function="recovery of photoreceptor dark state"
/note="activator-dependent; calcium sensitive; 450..1700
extracellular domain 1701..1769 transmembrane domain
1770..3623 cytoplasmic domain"
/codon_start=1
/product="guanylyl cyclase"
/protein_id="AAA74451.1"
/translation="MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSL
PQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNE
DCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKI
SYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGV
VLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTY
VFVPYDALLYSLPYKHTPYQVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARG
EIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQ
LMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADA
KCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILL
TLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIY
EGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTE
FCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRF
VLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIM
QEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQ
RPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKL
LTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYT
LFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHM
PEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVT
ILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQP
VEIAAFQRRKAERQLVRNKP"
sig_peptide 300..449
/gene="RetGC-2"
mat_peptide 450..3623
/gene="RetGC-2"
/product="guanylyl cyclase"
BASE COUNT 999 a 834 c 920 g 970 t
ORIGIN
1 cgatcactct tcagcatccg cagagtgatt ttcaaaacat ttactaacgc tttcaattat
61 ttaccccatt aatggaattt gtcaacagac tggagtcctt gacaggattg tgaatgcata
121 gaggatgcaa agaaatggac acactgaggt agctatgcca gtggtctgca tgcgcaggca
181 gtaaactgaa gacatttgag cggtgaatta cttggcattt ggaaacacca ccgtctgtgt
241 cgggaaagca gaataactct ccagtatctc gtcattagct tgctggaagc aggagggcta
301 tgttcctggg actcgggcgc ttttctcgcc ttgttctctg gtttgcggct ttcaggaaac
361 tgctgggaca ccatggcctt gcatctgcca agttcctgtg gtgcttgtgc cttctgtctg
421 tcatgtccct tccgcagcag gtgtggacac tcccctacaa gataggggtg gtgggccctt
481 gggcttgtga ttcgctgttt tcaaaggccc tgcctgaggt tgctgcgcga ttagccattg
541 agcgaatcaa ccgggaccca tcttttgacc tgagttattc ttttgaatac gtgattctca
601 atgaagactg ccagacttcg agggctctct ccagtttcat ttcccaccac cagatggcct
661 caggatttat tggacctacc aaccctggct actgcgaggc agcctcgctc ctgggaaaca
721 gctgggacaa aggaattttc tcttgggctt gtgtgaatta tgaattagac aataaaatta
781 gctacccgac cttttctcgg acactccctt ctcccatccg ggtgcttgta actgtcatga
841 aatatttcca gtgggctcat gctggagtca tttcctcaga tgaagacatt tgggtgcata
901 cagccaatcg agtcgcaagt gctcttcgga gccacggctt acctgtaggg gtcgtcctga
961 ccacaggaca agacagccaa agcatgcgga aagccctcca gaggattcac caggcagaca
1021 gaattcgcat aatcatcatg tgtatgcatt cagctttgat tgggggagag actcagatgc
1081 atctcttgga atgtgctcat gatctgaaaa tgactgatgg aacctacgtc tttgttcctt
1141 atgatgccct gctctacagt ttaccttata agcacacccc ctaccaggtc ctaaggaaca
1201 acccaaagct ccgggaagcc tatgatgcag tgttgaccat tacagtggag tcccaagaaa
1261 agaccttcta tcaagccttc acagaggcag cagcaagagg tgaaattcct gagaagctgg
1321 agttcgatca agtttcaccg ttgtttggaa ccatctacaa ttcaatttac tttatcgcac
1381 aagccatgaa taatgctatg aaagaaaatg gacaggctgg tgctgccagc ctggttcagc
1441 attccagaaa catgcagttc catggattca accagttgat gaggacagat tcaaatggaa
1501 atggaatttc agaatatgta atcctggaca ccaacttgaa agaatgggaa ctccatagca
1561 cctacactgt ggacatggaa atggagctgc tacgtttcgg agggacccct attcacttcc
1621 ctggtggcag gccccctaga gcagatgcaa aatgctggtt tgcagaaggg aagatctgcc
1681 atggaggcat cgaccctgcc tttgccatga tggtctgcct tactttgctt atagccctgc
1741 tgtctattaa tggatttgct tactttataa ggcgtcgtat aaataaaatc cagttgatca
1801 aaggacccaa tagaattcta ctgactttgg aggatgtaac gtttatcaat ccccactttg
1861 gcagtaagag aggaagtcgt gccagtgtaa gcttccagat tacctcagag gtccaaagtg
1921 ggaggtcccc aagactctcc ttttcttcag ggagtctaac tccagctacc tatgaaaact
1981 ccaacatagc gatttatgag ggtgattggg tgtggctgaa aaagttctcc cttggagatt
2041 ttggagacct taagtccatc aaatcaagag caagtgatgt gttcgaaatg atgaaggact
2101 tgcgtcatga gaatattaac cctttattgg gtttcttcta tgattcgggg atgtttgcca
2161 ttgtgacaga attctgttcc cgagggagcc tagaagacat actgacaaat caagatgtga
2221 aacttgactg gatgtttaaa tcatcactct tgctggatct cataaagggc atgaagtact
2281 tacaccacag agagtttgtt catgggaggc taaagtctcg aaactgtgtg gtagatgggc
2341 gttttgtact aaaagtgaca gattatggct ttaacgacat cttagaaatg ctgagactct
2401 ctgaagagga atcttctatg gaagagctgc tgtggacggc ccctgaactg ttgagagctc
2461 caagaggcag caggttaggt tcttttgcag gagatgtcta tagctttgcc atcatcatgc
2521 aagaagtgat ggtccggggt accccattct gcatgatgga tctgccagct caagaaatca
2581 taaacagact taagaagcct cctcctgtgt acagaccagt agttcctcct gagcatgccc
2641 ctccagaatg tctccagctg atgaagcagt gctgggctga ggctgcagaa caacgaccaa
2701 cttttgatga aatatttaac cagtttaaaa cttttaataa agggaagaag accaatatta
2761 ttgattctat gcttcggatg ttggagcaat attctagcaa cttggaagat ttgattcggg
2821 agcggactga agagctggaa attgaaaaac agaaaacgga aaagcttcta acacagatgc
2881 taccaccatc agttgctgaa tctctcaaaa agggctgcac agttgaacct gagggctttg
2941 acttggtcac cttgtacttc agcgacattg tgggcttcac aaccatttca gccatgagtg
3001 agcccattga ggtcgtggat cttctgaatg acctgtacac actctttgat gcaataattg
3061 gcagtcatga tgtctacaag gtagagacca ttggagatgc ctacatggtg gcttcaggcc
3121 tcccaaagag gaatggcagt aggcatgcag ctgagattgc aaacatgtcc ttagatatcc
3181 tgagctctgt gggcactttc aagatgcggc acatgccaga agtgccggtc cgaattcgaa
3241 ttggccttca ctcagggccg gttgttgctg gagtggtggg cctcaccatg cccagatact
3301 gcttgtttgg agacactgtg aacacagctt ctcggatgga atctacaggc ttaccttatc
3361 gcattcatgt cagtctcagc actgttacaa ttcttcaaaa tctgagtgag ggctatgaag
3421 tggagcttcg aggaagaaca gagctcaagg gcaaaggcac agaggaaacc ttctggctga
3481 ttgggaaaaa aggcttcatg aagccccttc ctgtgccccc accagtggac aaagatgggc
3541 aagtgggcca tggcctgcaa ccagtggaga ttgcagcctt ccaaagaaga aaagcagaaa
3601 ggcagttggt gagaaacaag ccataagggg caaagggctc caggatttga atcttctctt
3661 ggtgaggcaa tgggaaagct cacttcagtt caagaaattg ttctgcctgg gcaagaaatt
3721 acg
//