LOCUS HUMMKK4A 3576 bp mRNA linear HUM 28-FEB-1995
DEFINITION Homo sapiens MAP kinase kinase 4 (MKK4) mRNA, complete cds.
ACCESSION L36870
VERSION L36870.1
KEYWORDS MAP kinase kinase; MAP kinase kinase 4; mitogen activated protein
kinase; protein kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3576)
AUTHORS Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
Ulevitch,R.J. and Davis,R.J.
TITLE Independent human MAP-kinase signal transduction pathways defined
by MEK and MKK isoforms
JOURNAL Science 267 (5198), 682-685 (1995)
PUBMED 7839144
COMMENT Original source text: Homo sapiens brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3576
/db_xref="H-InvDB:HIT000193276"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
/note="(vector lambda ZAPII)"
gene 1..3576
/gene="MKK4"
mRNA 1..3576
/gene="MKK4"
5'UTR 1..9
/gene="MKK4"
CDS 10..1209
/gene="MKK4"
/standard_name="protein kinase"
/codon_start=1
/product="MAP kinase kinase 4"
/protein_id="AAC41719.1"
/translation="MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKAL
KLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDL
KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPY
IVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH
LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID
PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEER
EFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATP
SSPMYVD"
3'UTR 1210..3576
/gene="MKK4"
BASE COUNT 1052 a 751 c 753 g 1020 t
ORIGIN
1 ctcccaacaa tggcggctcc gagcccgagc ggcggcggcg gctccggggg cggcagcggc
61 agcggcaccc ccggccccgt agggtccccg gcgccaggcc acccggccgt cagcagcatg
121 cagggtaaac gcaaagcact gaagttgaat tttgcaaatc cacctttcaa atctacagca
181 aggtttactc tgaatcccaa tcctacagga gttcaaaacc cacacataga gagactgaga
241 acacacagca ttgagtcatc aggaaaactg aagatctccc ctgaacaaca ctgggatttc
301 actgcagagg acttgaaaga ccttggagaa attggacgag gagcttatgg ttctgtcaac
361 aaaatggtcc acaaaccaag tgggcaaata atggcagtta aaagaattcg gtcaacagtg
421 gatgaaaaag aacaaaaaca acttcttatg gatttggatg tagtaatgcg gagtagtgat
481 tgcccataca ttgttcagtt ttatggtgca ctcttcagag agggtgactg ttggatctgt
541 atggaactca tgtctacctc gtttgataag ttttacaaat atgtatatag tgtattagat
601 gatgttattc cagaagaaat tttaggcaaa atcactttag caactgtgaa agcactaaac
661 cacttaaaag aaaacttgaa aattattcac agagatatca aaccttccaa tattcttctg
721 gacagaagtg gaaatattaa gctctgtgac ttcggcatca gtggacagct tgtggactct
781 attgccaaga caagagatgc tggctgtagg ccatacatgg cacctgaaag aatagaccca
841 agcgcatcac gacaaggata tgatgtccgc tctgatgtct ggagtttggg gatcacattg
901 tatgagttgg ccacaggccg atttccttat ccaaagtgga atagtgtatt tgatcaacta
961 acacaagtcg tgaaaggaga tcctccgcag ctgagtaatt ctgaggaaag ggaattctcc
1021 ccgagtttca tcaactttgt caacttgtgc cttacgaagg atgaatccaa aaggccaaag
1081 tataaagagc ttctgaaaca tccctttatt ttgatgtatg aagaacgtgc cgttgaggtc
1141 gcatgctatg tttgtaaaat cctggatcaa atgccagcta ctcccagctc tcccatgtat
1201 gtcgattgat atcgctgcta catcagactc tagaaaaaag ggctgagagg aagcaagacg
1261 taaagaattt tcatcccgta tcacagtgtt tttattgctc gcccagacac catgtgcaat
1321 aagattggtg ttcgtttcca tcatgtctgt atactcctgt cacctagaac gtgcatcctt
1381 gtaatacctg attgatcaca cagtgttagt gctggtcaga gagacctcat cctgctcttt
1441 tgtgatgaac atattcatga aatgtggaag tcagtacgat caagttgttg actgtgatta
1501 gatcacatct taaattcatt tctagactca aaacctggag atgcagctac tggaatggtg
1561 ttttgtcaga cttccaaatc ctggaaggac acagtgatga atgtactata tctgaacata
1621 gaaactcggg cttgagtgag aagagcttgc acagccaacg agacacattg ccttctggag
1681 ctgggagaca aaggaggaat ttactttctt caccaagtgc aatagattac tgatgtgata
1741 ttctgttgct ttacagttac agttgatgtt tggggatcga tgtgctcagc caaatttcct
1801 gtttgaaata tcatgttaaa ttagaatgaa tttatcttta ccaaaaacca tgttgcgttc
1861 aaagaggtga acattaaaat atagagacag gacagaatgt gttcttttct cctctaccag
1921 tcctattttt caatgggaag actcaggagt ctgccacttg tcaaagaagg tgctgatcct
1981 aagaattttt cattctcaga attcggtgtg ctgccaactt gatgttccac ctgccacaaa
2041 ccaccaggac tgaaagaaga aaacagtaca gaaggcaaag tttacagatg tttttaattc
2101 tagtatttta tctggaacaa cttgtagcag ctatatattt ccccttggtc ccaagcctga
2161 tactttagcc atcataactc actaacaggg agaagtagct agtagcaatg tgccttgatt
2221 gattagataa agatttctag taggcagcaa aagaccaaat ctcagttgtt tgcttcttgc
2281 catcactggt ccaggtcttc agtttccgaa tctctttccc ttcccctgtg gtctattgtc
2341 gctatgtgac ttgcgcttaa tccaatattt tgcctttttt ctatatcaaa aaacctttac
2401 agttagcagg gatgttcctt accgaggatt tttaaccccc aatctctcat aatcgctagt
2461 gtttaaaagg ctaagaatag tggggcccaa ccgatgtggt aggtgataaa gaggcatctt
2521 ttctagagac acattggacc agatgaggat ccgaaacggc agcctttacg ttcatcacct
2581 gctagaacct ctcgtagtcc atcaccattt cttggcattg gaattctact ggaaaaaaat
2641 acaaaaagca aaacaaaacc ctcagcactg ttacaagagg ccatttaagt atcttgtgct
2701 tcttcactta cccattagcc aggttctcat taggttttgc ttgggcctcc ctggcactga
2761 accttaggct ttgtatgaca gtgaagcagc actgtgagtg gttcaagcac actggaatat
2821 aaaacagtca tggcctgaga tgcaggtgat gccattacag aaccaaatcg tggcacgtat
2881 tgctgtgtct cctctcagag tgacagtcat aaatactgtc aaacaataaa gggagaatgg
2941 tgctgtttaa agtcacatcc ctgtaaattg cagaattcaa aagtgattat ctctttgatc
3001 tacttgcctc atttccctat cttctccccc acggtatcct aaactttaga cttcccactg
3061 ttctgaaagg agacattgct ctatgtctgc cttcgaccac agcaagccat catcctccat
3121 tgctcccggg gactcaagag gaatctgttt ctctgctgtc aacttcccat ctggctcagc
3181 atagggtcac tttgccatta tgcaaatgga gataaaagca attctggctg tccaggagct
3241 aatctgaccg ttctattgtg tggatgacca cataagaagg caattttagt gtattaatca
3301 tagattatta taaactataa acttaagggc aaggagttta ttacaatgta tctttattaa
3361 aacaaaaggg tgtatagtgt tcacaaactg tgaaaatagt gtaagaactg tacattgtga
3421 gctctggtta tttttctctt gtaccataga aaaatgtata aaaattatca aaaagctaat
3481 gtgcagggat attgccttat ttgtctgtaa aaaatggagc tcagtaacat aactgcttct
3541 tggagctttg gaatatttta tcctgtattc ttgttt
//