LOCUS HUMAUTOTAX 3231 bp mRNA linear HUM 05-APR-1995
DEFINITION Human autotaxin mRNA, complete cds.
ACCESSION L35594
VERSION L35594.1
KEYWORDS autotaxin; tumor motility-stimulating protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3231)
AUTHORS Murata,J., Lee,H.Y., Clair,T., Krutzsch,H.C., Arestad,A.A.,
Sobel,M.E., Liotta,L.A. and Stracke,M.L.
TITLE cDNA cloning of the human tumor motility-stimulating protein,
autotaxin, reveals a homology with phosphodiesterases
JOURNAL J. Biol. Chem. 269 (48), 30479-30484 (1994)
PUBMED 7982964
COMMENT Original source text: human cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3231
/db_xref="H-InvDB:HIT000193234"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/cell_line="A2058; established from brain metastasis"
/cell_type="melanoma"
/tissue_type="tumor"
/dev_stage="adult"
mRNA 1..3231
CDS 50..2797
/codon_start=1
/product="autotaxin"
/protein_id="AAA64785.1"
/translation="MARRSSFQSCQIISLFTFAVGVSICLGFTAHRIKRAEGWEEGPP
TVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWE
CTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAG
FVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLA
TGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFW
SVVIPHERRILTILRWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTP
AKRPKRKVAPKRRQERPVAPPKKRRRKIHRMDHYAAETRQDKMTNPLREIDKIVGQLM
DGLKQLKLRRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFS
NNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVAR
KPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMC
DLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDK
VEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMLL
WTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSS
SPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGL
HDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEE
SCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYESE
I"
BASE COUNT 947 a 692 c 712 g 880 t
ORIGIN
1 cgtgaaggca aagagaacac gctgcaaaag gcttccaaga atcctcgaca tggcaaggag
61 gagctcgttc cagtcgtgtc agataatatc cctgttcact tttgccgttg gagtcagtat
121 ctgcttagga ttcactgcac atcgaattaa gagagcagaa ggatgggagg aaggtcctcc
181 tacagtgcta tcagactccc cctggaccaa catctccgga tcttgcaagg gcaggtgctt
241 tgaacttcaa gaggctggac ctcctgattg tcgctgtgac aacttgtgta agagctatac
301 cagttgctgc catgactttg atgagctgtg tttgaagaca gcccgtggct gggagtgtac
361 taaggacaga tgtggagaag tcagaaatga agaaaatgcc tgtcactgct cagaggactg
421 cttggccagg ggagactgct gtaccaatta ccaagtggtt tgcaaaggag agtcgcattg
481 ggttgatgat gactgtgagg aaataaaggc cgcagaatgc cctgcagggt ttgttcgccc
541 tccattaatc atcttctccg tggatggctt ccgtgcatca tacatgaaga aaggcagcaa
601 agtcatgcct aatattgaaa aactaaggtc ttgtggcaca cactctccct acatgaggcc
661 ggtgtaccca actaaaacct ttcctaactt atacactttg gccactgggc tatatccaga
721 atcacatgga attgttggca attcaatgta tgatcctgta tttgatgcca cttttcatct
781 gcgagggcga gagaaattta atcatagatg gtggggaggt caaccgctat ggattacagc
841 caccaagcaa ggggtgaaag ctggaacatt cttttggtct gttgtcatcc ctcacgagcg
901 gagaatatta accatattgc ggtggctcac cctgccagat catgagaggc cttcggtcta
961 tgccttctat tctgagcaac ctgatttctc tggacacaaa tatggccctt tcggccctga
1021 ggagagtagt tatggctcac cttttactcc ggctaagaga cctaagagga aagttgcccc
1081 taagaggaga caggaaagac cagttgctcc tccaaagaaa agaagaagaa aaatacatag
1141 gatggatcat tatgctgcgg aaactcgtca ggacaaaatg acaaatcctc tgagggaaat
1201 cgacaaaatt gtggggcaat taatggatgg actgaaacaa ctaaaactgc gtcggtgtgt
1261 caacgtcatc tttgtcggag accatggaat ggaagatgtc acatgtgata gaactgagtt
1321 cttgagtaat tacctaacta atgtggatga tattacttta gtgcctggaa ctctaggaag
1381 aattcgatcc aaatttagca acaatgctaa atatgacccc aaagccatta ttgccaatct
1441 cacgtgtaaa aaaccagatc agcactttaa gccttacttg aaacagcacc ttcccaaacg
1501 tttgcactat gccaacaaca gaagaattga ggatatccat ttattggtgg aacgcagatg
1561 gcatgttgca aggaaacctt tggatgttta taagaaacca tcaggaaaat gctttttcca
1621 gggagaccac ggatttgata acaaggtcaa cagcatgcag actgtttttg taggttatgg
1681 cccaacattt aagtacaaga ctaaagtgcc tccatttgaa aacattgaac tttacaatgt
1741 tatgtgtgat ctcctgggat tgaagccagc tcctaataat gggacccatg gaagtttgaa
1801 tcatctcctg cgcactaata ccttcaggcc aaccatgcca gaggaagtta ccagacccaa
1861 ttatccaggg attatgtacc ttcagtctga ttttgacctg ggctgcactt gtgatgataa
1921 ggtagagcca aagaacaagt tggatgaact caacaaacgg cttcatacaa aagggtctac
1981 agaagagaga cacctcctct atgggcgacc tgcagtgctt tatcggacta gatatgatat
2041 cttatatcac actgactttg aaagtggtta tagtgaaata ttcctaatgc tactctggac
2101 atcatatact gtttccaaac aggctgaggt ttccagcgtt cctgaccatc tgaccagttg
2161 cgtccggcct gatgtccgtg tttctccgag tttcagtcag aactgtttgg cctacaaaaa
2221 tgataagcag atgtcctacg gattcctctt tcctccttat ctgagctctt caccagaggc
2281 taaatatgat gcattccttg taaccaatat ggttccaatg tatcctgctt tcaaacgggt
2341 ctggaattat ttccaaaggg tattggtgaa gaaatatgct tcggaaagaa atggagttaa
2401 cgtgataagt ggaccaatct tcgactatga ctatgatggc ttacatgaca cagaagacaa
2461 aataaaacag tacgtggaag gcagttccat tcctgttcca actcactact acagcatcat
2521 caccagctgt ctggatttca ctcagcctgc cgacaagtgt gacggccctc tctctgtgtc
2581 ctccttcatc ctgcctcacc ggcctgacaa cgaggagagc tgcaatagct cagaggacga
2641 atcaaaatgg gtagaagaac tcatgaagat gcacacagct agggtgcgtg acattgaaca
2701 tctcaccagc ctggacttct tccgaaagac cagccgcagc tacccagaaa tcctgacact
2761 caagacatac ctgcatacat atgagagcga gatttaactt tctgagcatc tgcagtacag
2821 tcttatcaac tggttgtata tttttatatt gtttttgtat ttattaattt gaaaccagga
2881 cattaaaaat gttagtattt taatcctgta ccaaatctga catattatgc ctgaatgact
2941 ccactgtttt tctctaatgc ttgatttagg tagccttgtg ttctgagtag agcttgtaat
3001 aaatactgca gcttgagaaa aagtggaagc ttctaaatgg tgctgcagat ttgatatttg
3061 cattgaggaa atattaattt tccaatgcac agttgccaca tttagtcctg tactgtatgg
3121 aaacactgat tttgtaaagt tgcctttatt tgctgttaac tgttaactat gacagatata
3181 tttaagcctt ataaaccaat cttaaacata ataaatcaca cattcagttt t
//