LOCUS       HUMIGKZM                 451 bp    mRNA    linear   HUM 26-JUL-1995
DEFINITION  Human immunoglobulin light chain variable region (Vk-IV subgroup)
            for anti-B-amyloid autoantibodies in Alzheimer's disease.
ACCESSION   L33854
VERSION     L33854.1
KEYWORDS    Alzheimer's disease; Ig light chain; anti-B-amyloid autoantibodies;
            variable region subgroup Vk-IV.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Fang,Q., Kannapell,C.C., Fu,S.M., Xu,S. and Gaskin,F.
  TITLE     VH and VL gene usage by anti-beta-amyloid autoantibodies in
            Alzheimer's disease: detection of highly mutated V regions in both
            heavy and light chains
  JOURNAL   Clin. Immunol. Immunopathol. 75 (2), 159-167 (1995)
   PUBMED   7704974
COMMENT     Original source text: Homo sapiens peripheral blood cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="2p12"
                     /cell_line="MRE 148"
                     /cell_type="non-T"
                     /tissue_type="peripheral blood"
     gene            1..451
                     /gene="IGKV"
     CDS             20..>451
                     /gene="IGKV"
                     /codon_start=1
                     /product="immunoglobulin kappa chain variable region"
                     /protein_id="AAA72132.1"
                     /db_xref="GDB:G00-119-341"
                     /translation="MVLQTQVFISLLLWISGAYGDIVMTQSPDSLAVSLGERASINCK
                     SSQSIFYASNNKDYLAWYQQKPGQPPKLLIYWASARESGVPDRFSGGGSGTDFTLTIS
                     SLQAEDVAVYYCQQYYDAPLTFGGGTKVEIKRTVAAPSVFIF"
BASE COUNT           95 a          123 c          123 g          110 t
ORIGIN      
        1 ggcaggcagg ggcagcaaga tggtgttgca gacccaggtc ttcatttctc tgttgctctg
       61 gatctctggt gcctacgggg acatcgtgat gacccagtct ccagactccc tggctgtgtc
      121 tctgggcgag agggcctcca tcaactgcaa gtccagccag agtatttttt acgcctccaa
      181 caataaggac tacttagctt ggtaccagca gaaaccagga cagcctccta agctgctcat
      241 ttactgggca tctgcccggg aatccggggt ccctgaccga ttcagtggcg gggggtctgg
      301 gacagatttc actctcacca tcagcagcct gcaggctgaa gatgtggcag tttattactg
      361 tcagcaatat tatgatgccc ctctcacttt cggcggaggg accaaggtgg agatcaaacg
      421 aactgtggct gcaccatctg tgttcatctt c
//