LOCUS HUMIGKZM 451 bp mRNA linear HUM 26-JUL-1995 DEFINITION Human immunoglobulin light chain variable region (Vk-IV subgroup) for anti-B-amyloid autoantibodies in Alzheimer's disease. ACCESSION L33854 VERSION L33854.1 KEYWORDS Alzheimer's disease; Ig light chain; anti-B-amyloid autoantibodies; variable region subgroup Vk-IV. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 451) AUTHORS Fang,Q., Kannapell,C.C., Fu,S.M., Xu,S. and Gaskin,F. TITLE VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains JOURNAL Clin. Immunol. Immunopathol. 75 (2), 159-167 (1995) PUBMED 7704974 COMMENT Original source text: Homo sapiens peripheral blood cDNA to mRNA. FEATURES Location/Qualifiers source 1..451 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="2p12" /cell_line="MRE 148" /cell_type="non-T" /tissue_type="peripheral blood" gene 1..451 /gene="IGKV" CDS 20..>451 /gene="IGKV" /codon_start=1 /product="immunoglobulin kappa chain variable region" /protein_id="AAA72132.1" /db_xref="GDB:G00-119-341" /translation="MVLQTQVFISLLLWISGAYGDIVMTQSPDSLAVSLGERASINCK SSQSIFYASNNKDYLAWYQQKPGQPPKLLIYWASARESGVPDRFSGGGSGTDFTLTIS SLQAEDVAVYYCQQYYDAPLTFGGGTKVEIKRTVAAPSVFIF" BASE COUNT 95 a 123 c 123 g 110 t ORIGIN 1 ggcaggcagg ggcagcaaga tggtgttgca gacccaggtc ttcatttctc tgttgctctg 61 gatctctggt gcctacgggg acatcgtgat gacccagtct ccagactccc tggctgtgtc 121 tctgggcgag agggcctcca tcaactgcaa gtccagccag agtatttttt acgcctccaa 181 caataaggac tacttagctt ggtaccagca gaaaccagga cagcctccta agctgctcat 241 ttactgggca tctgcccggg aatccggggt ccctgaccga ttcagtggcg gggggtctgg 301 gacagatttc actctcacca tcagcagcct gcaggctgaa gatgtggcag tttattactg 361 tcagcaatat tatgatgccc ctctcacttt cggcggaggg accaaggtgg agatcaaacg 421 aactgtggct gcaccatctg tgttcatctt c //