LOCUS HUMCACNLA 6160 bp mRNA linear HUM 02-NOV-1994
DEFINITION Human dihydropyridine-sensitive L-type calcium channel alpha-1
subunit (CACNL1A3) mRNA, complete cds.
ACCESSION L33798
VERSION L33798.1
KEYWORDS calcium channel; dihydropyridine-sensitive L-type calcium channel
alpha-1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6160)
AUTHORS Hogan,K., Powers,P.A. and Gregg,R.G.
TITLE Cloning of the human skeletal muscle alpha1 subunit of the
dihydropyridine-sensitive caclium channels (CACNL1A3)
JOURNAL Genomics (1994) In press
COMMENT Original source text: Homo sapiens female adult skeletal muscle
cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..6160
/db_xref="H-InvDB:HIT000193097"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1q31-32"
/sex="female"
/tissue_type="skeletal muscle"
/dev_stage="adult"
gene 1..6160
/gene="CACNL1A3"
5'UTR 1..225
/gene="CACNL1A3"
/note="G00-126-431; putative"
CDS 226..5847
/gene="CACNL1A3"
/note="putative"
/codon_start=1
/product="dihydropyridine-sensitive L-type calcium channel
alpha-1 subunit"
/protein_id="AAA51902.1"
/db_xref="GDB:G00-126-431"
/translation="MEPSSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLENPLRKAC
ISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAA
MKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLD
VKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELF
KGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGCPGPNHGITHFD
NFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLS
GEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFREGKLSLDEGG
SDTESLYEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVALNTLSIA
SEHHNQPHWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGI
LEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLL
FLFIVIFRLLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGI
MASSGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKK
RRKMSKGLPDKSEEEKSTMAKKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSAD
FPGDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNA
TWFTNFILLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGA
FLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAINRAKGL
KHVARCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYY
YVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAED
VGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQC
VQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQM
NHISDILNVAFTIIFTLEMILKLMAFKARGYFGNPWNVFDFLIVIGSIIDVILSEIDT
FLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIK
SFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVA
VIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFG
KFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAII
KKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYRPKKDI
VQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAMEEGIFRRTGGLFGQVDN
FLERTNSLPPVMANQRPLQFAEIEMEEMESPVFLEDFPQDPRTNPLARANTNNANANV
AYANSNHSNSHVFSSVHYEREFPEETETPATRGRALGQPCRSLGPHSKPCVEMLKGLL
TQRAMPRGQAPPAPCQCPRVESSMPEDRKSSTPGSLHEETPHSRSTRENTSRCSAPAT
ALLIQKALVRGGLGTLAADANFIMATGQALGDACQMEPEEVEIMATELLKGREAPDGM
ASSLGCLNLGSSLGSLDQHQGSQETLIPPRL"
3'UTR 5848..6159
/gene="CACNL1A3"
/note="G00-126-431"
polyA_site 6160
/gene="CACNL1A3"
/note="G00-126-431"
BASE COUNT 1389 a 1796 c 1672 g 1303 t
ORIGIN
1 tcaggccggc agcggggagc cgagtggagg ctaattttac ttgctgggag cgaggagagt
61 aatcctcctg ccccccactc ctgccccgcc ccctggctgg ctcagcaggg cagctcagcc
121 gacagcctca gccagcctag tccccaaggc gggggcattg gggacacagg gaagggaaag
181 cactggggtg ggggagcagg agaaagccag attcccaggg aagccatgga gccatcctca
241 ccccaggatg aaggcctgag gaagaaacag cccaagaagc cagttcctga gattctgcca
301 aggccacccc gggctttgtt ctgcctgacc ctggagaacc ccctgaggaa ggcctgcatc
361 agcattgtag aatggaagcc cttcgagacg atcatcttgc tcaccatctt tgccaattgt
421 gtggccctgg ccgtgtacct gcccatgccg gaagatgaca acaactctct gaacctcggc
481 ctggagaagc tggagtattt cttcctcatt gtcttctcga ttgaagccgc catgaagatc
541 attgcctacg gcttcttatt ccaccaggac gcttacctgc gcagtggctg gaatgtgctg
601 gacttcacca ttgtcttcct gggggtcttc accgtgattc tggaacaggt taacgtcatc
661 caaagccaca cagccccaat gagcagcaaa ggagccggct tggatgtcaa ggccctcaga
721 gccttccgag tgctcagacc cctccggctg gtgtcggggg tgcctagcct gcaggtggtc
781 ctgaactcca tcttcaaggc catgctcccc ctctttcaca tcgccctgct ggtcctcttt
841 atggtcatca tctatgccat catcgggctg gagctcttca agggcaagat gcacaagacc
901 tgctacttca ttggtacaga tatcgtggcc acggtggaga atgaagagcc atcgccctgc
961 gccaggacgg gctcagggcg ccggtgcacc atcaatggca gtgagtgccg gggcggctgc
1021 ccagggccca accatggcat cacccacttc gacaacttcg gcttctccat gctcaccgtg
1081 taccagtgca ttaccatgga gggatggact gacgtccttt actgggtcaa tgatgccatc
1141 gggaatgagt ggccctggat ctattttgtc accctcattt tgctgggatc cttcttcatc
1201 ctcaacctgg tgctgggtgt cctgagtggg gaattcacca aggagcggga gaaggccaag
1261 tccaggggaa ccttccagaa gctccgggag aagcagcaac tagatgagga ccttcggggc
1321 tacatgagct ggatcacgca gggcgaggtc atggatgttg aggacttcag agaaggaaaa
1381 ctgtctttgg atgaaggtgg ctctgacaca gagagcctgt atgaaattgc aggcttgaac
1441 aaaatcatcc agttcatccg acattggagg cagtggaacc gcatctttcg ctggaagtgc
1501 catgacatcg tgaagtccaa ggtcttctat tggctggtga ttctcatcgt tgccctcaac
1561 accctgtcta tcgcctcaga gcaccacaac cagccgcact ggctgacccg tttgcaagac
1621 attgccaacc gggtgctgct gtccctcttc accactgaga tgctgatgaa gatgtacggg
1681 ctgggcctgc gccagtactt catgtctatc ttcaaccgct tcgactgctt cgtggtgtgc
1741 agcggtatcc tggagatcct gctggtggag tcgggcgcca tgacacccct gggcatctcc
1801 gtgctccgct gcatccgcct cctgaggatc ttcaagatca ccaaatattg gacgtcgctg
1861 agcaacctgg tggcatccct gctcaactcc atccgctcca tcgcctccct gctgctgctg
1921 ctcttcctct tcatcgtcat cttccgcctc ctgggcatgc agctctttgg ggggaggtat
1981 gactttgaag acacagaagt acggcgcagc aactttgaca actttcccca agccctcatc
2041 agcgtcttcc aggtactgac aggggaagac tggacctcaa tgatgtacaa tgggatcatg
2101 gcctcgagcg ggccgtccta ccctggcatg cttgtgtgca tttacttcat catccttttc
2161 gtctgtggca actacatcct gctcaatgtc ttcctggcca ttgccgtgga caacctggcc
2221 gaggcggaga gcctgacttc tgcccagaag gccaaggctg aggagaaaaa acgcaggaag
2281 atgtccaagg gtctcccaga caagtcagaa gaggagaagt caacgatggc caagaagctg
2341 gagcagaaac ccaagggtga gggcatcccc accactgcca agctgaaaat cgatgagttt
2401 gaatctaatg tcaatgaggt gaaggatccc tacccctcag ccgacttccc aggggatgac
2461 gaggaagatg agcctgagat cccgctgagc ccccgaccac gtcccctggc tgagctgcag
2521 ctgaaagaga aggccgtgcc cattccagaa gccagctcct tcttcatctt cagccccacc
2581 aataagatcc gtgtcctgtg tcaccgcatc gtcaatgcca cctggttcac caacttcatc
2641 ctgctcttca tcctgctcag cagcgctgca ctggctgcgg aagaccccat ccgggctgat
2701 tccatgagaa atcagatcct taaacacttt gacatcgggt tcacctctgt cttcactgtg
2761 gagattgtcc tcaagatgac gacctacgga gccttcctgc acaagggttc cttctgccgc
2821 aattacttca acatgctgga cctgctggtg gtggccgtgt ccctcatctc catgggactt
2881 gagtccagtg ccatctccgt ggtgaagatc ctgagggtgc tgagggtgct ccgaccactc
2941 agagccatca acagagccaa ggggttgaag cacgtggcta ggtgcatgtt cgtggccatc
3001 agcaccatcg ggaacatcgt gctggtcact accctcctac agttcatgtt tgcctgcatc
3061 ggcgtccagc tcttcaaggg gaagttcttc aggtgcaccg acttgtccaa gatgacagag
3121 gaggagtgca ggggctacta ctacgtgtac aaggacgggg accccatgca gatagagctg
3181 cgtcaccgcg agtgggtaca cagcgacttc cacttcgaca atgtgctctc agccatgatg
3241 tccctcttca cggtctccac cttcgaggga tggcctcagc tgctgtacaa ggccatagac
3301 tccaatgcgg aggacgtggg tcccatctac aacaaccgtg tggagatggc catcttcttc
3361 atcatctaca tcatcctcat tgccttcttc atgatgaaca tctttgtggg cttcgtcatt
3421 gtcaccttcc aggagcaggg agagactgag tacaagaact gtgagctgga caagaaccag
3481 cgccaatgtg tacagtatgc cctgaaggcc cgcccactga ggtgctacat tcccaaaaac
3541 ccataccagt accaggtgtg gtacattgtc acctcctcct actttgaata cctgatgttt
3601 gccctcatca tgctcaacac catctgcctc ggcatgcagc actacaacca gtcggagcag
3661 atgaaccaca tctcagacat cctcaatgtg gccttcacta tcatcttcac cctggagatg
3721 atcctcaagc tcatggcctt caaggccagg ggctactttg gaaacccctg gaatgtgttt
3781 gacttcctga ttgtcattgg cagcatcatt gatgtcatcc tcagtgagat cgacactttc
3841 ctggcctcca gcgggggact gtattgcctg ggtggaggct gcgggaacgt tgacccagat
3901 gagagtgccc gcatctccag cgccttcttc cgcctgttcc gtgtcatgag gctgatcaag
3961 ctgctgagcc gggcagaagg agtgcgaacc ctcctgtgga cgttcatcaa gtccttccag
4021 gccctaccct acgtggctct gctcatcgtc atgctcttct tcatctacgc tgtcatcggc
4081 atgcagatgt ttgggaagat cgccttggtg gatgggaccc aaataaaccg gaacaacaac
4141 ttccagacct tcccacaagc tgtgctactg ctcttcaggt gtgcaacagg tgaggcctgg
4201 caggagatcc tactggcctg cagctatggg aagctgtgtg acccagagtc ggactatgcc
4261 ccaggggagg agtacacatg tggcaccaac tttgcatact actacttcat cagcttctac
4321 atgctctgtg ccttcctggt catcaacctc tttgtggctg tcatcatgga caattttgac
4381 tacctcaccc gggactggtc catcctgggc cctcatcacc tggatgagtt caaggccatc
4441 tgggcagagt atgacccaga ggctaagggg aggatcaaac acctggacgt ggtgaccctg
4501 ctgagaagga ttcagccccc tctgggcttt gggaagttct gcccacatcg ggtagcttgt
4561 aagcggctgg tgggcatgaa catgcccctg aacagcgacg gcacagtcac cttcaatgcc
4621 acactctttg ccctggtccg cacggcactc aagatcaaga cggaaggtaa ctttgagcag
4681 gccaacgagg agctgagggc catcatcaag aagatctgga agagaaccag catgaagctc
4741 ttggaccagg tcatccctcc aataggagat gatgaggtga cagtggggaa gttctacgcc
4801 acattcctca tccaggagca cttccggaag ttcatgaaac gccaagagga gtattatggc
4861 tatcggccca agaaggacat tgtacagatc caggcagggc tgcggaccat tgaggaagag
4921 gcagcccccg agatctgtcg cacggtctca ggagacctgg ctgctgagga ggagctggag
4981 agagccatgg tggaggctgc gatggaggag gggatattcc ggaggactgg aggcctgttt
5041 ggccaggtgg acaacttcct ggaaaggacc aactccctgc cccctgtcat ggccaatcag
5101 agacccctcc agtttgctga gatagagatg gaagagatgg agtcacctgt cttcttggag
5161 gacttcccac aagatccacg caccaacccc ctggctcgtg ccaataccaa caatgccaac
5221 gccaatgtcg cctatgcgaa cagcaaccat agcaacagcc atgtgttttc cagtgtccac
5281 tatgaaaggg agttcccaga agagacagag acgcctgcta ccagaggacg agcccttggc
5341 caaccctgca ggtccctggg accccacagc aaaccctgtg tggagatgct gaagggactg
5401 ctgacccaga gggcaatgcc cagaggccag gcacctcctg ccccctgcca gtgccccagg
5461 gtggagtcct ccatgcctga ggacagaaag agctccacac cagggtctct tcatgaggag
5521 acaccccaca gcaggagcac cagggagaat acttccaggt gctcagcacc agctacagcc
5581 ctgctgatcc aaaaggctct ggttcgaggg ggcctgggca ccttggcagc tgatgcaaac
5641 ttcatcatgg caacaggcca ggccctcgga gatgcctgcc aaatggaacc agaggaagtg
5701 gagatcatgg caacagagct actgaaagga cgagaggccc cagacggcat ggccagctcc
5761 ctgggatgcc tgaacctcgg gtcctccctg ggcagcctcg accaacacca gggctcccag
5821 gagaccctta ttcctccaag gctgtgatgc ccacacagca tcagcatggg cttagagctg
5881 gcatgaccaa tgggggtggg gaagttgctg gggtggagaa gggctagccc accgcagcag
5941 cctccctccc tctcagcagc tagatgcatg cctgaggcag ggtggtcagg aaccacctca
6001 aaaagtgcgg aggaagtagc tggacaggcc ctgcccctca ccagcaagag gcatgattgg
6061 atggagcttc taatgtcatt caaaaaggcc tggtcagtgc ctgtccctag ggccactccc
6121 acctgcagga cattaaaatc tccaggcctg tgacactggc
//