LOCUS HUMNRAMP 2007 bp mRNA linear HUM 27-DEC-1994
DEFINITION Homo sapiens integral membrane protein (NRAMP1) mRNA, complete cds.
ACCESSION L32185
VERSION L32185.1
KEYWORDS integral membrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2007)
AUTHORS Cellier,M., Govoni,G., Vidal,S., Kwan,T., Groulx,N., Liu,J.,
Sanchez,F., Skamene,E., Schurr,E. and Gros,P.
TITLE Human natural resistance-associated macrophage protein: cDNA
cloning, chromosomal mapping, genomic organization, and
tissue-specific expression
JOURNAL J. Exp. Med. 180 (5), 1741-1752 (1994)
PUBMED 7964458
COMMENT Original source text: Homo sapiens (clone library: lambda gt10)
adult spleen cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2007
/db_xref="H-InvDB:HIT000192881"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="chromosome 2q35-36"
/cell_line="THP1"
/tissue_type="spleen"
/clone_lib="lambda gt10"
/dev_stage="adult"
gene 1..2007
/gene="NRAMP1"
CDS 77..1729
/gene="NRAMP1"
/function="potential transporter"
/standard_name="macrophage-specific integral membrane
protein"
/note="N-glycosylation sites (aa 324..326, 338..340); PKC
phosphorylation sites (aa 40..42, 54..56, 117..119);
additional putative transmembrane domains a (aa 58..75)
and b (aa 137..158); binding-protein-dependent transport
system inner membrane component signature (aa 373..392);
transmembrane domains 1 through 10 (aa's): (84..105),
(168..186), (197..217), (241..259), (288..309),
(350..369), (401..418), (430..449), (469..488),
(496..517)"
/codon_start=1
/product="integral membrane protein"
/protein_id="AAA57521.1"
/translation="MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIP
IPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVL
GLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAF
NLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAR
PEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRAD
IREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIF
PMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLR
LRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFT
SMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYL
GLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG"
BASE COUNT 372 a 656 c 548 g 431 t
ORIGIN
1 tctgggcacg ggtgcaggct gaggagctgc ccagagcacc gctcacactc ccagagtacc
61 tgaagtcggc atttcaatga caggtgacaa gggtccccaa aggctaagcg ggtccagcta
121 tggttccatc tccagcccga ccagcccgac cagcccaggg ccacagcaag cacctcccag
181 agagacctac ctgagtgaga agatccccat cccagacaca aaaccgggca ccttcagcct
241 gcggaagcta tgggccttca cggggcctgg cttcctcatg agcattgctt tcctggaccc
301 aggaaacatc gagtcagatc ttcaggctgg cgccgtggcg ggattcaaac ttctctgggt
361 gctgctctgg gccaccgtgt tgggcttgct ctgccagcga ctggctgcac gtctgggcgt
421 ggtgacaggc aaggacttgg gcgaggtctg ccatctctac taccctaagg tgccccgcac
481 cgtcctctgg ctgaccatcg agctagccat tgtgggctcc gacatgcagg aagtcatcgg
541 cacggccatt gcattcaatc tgctctcagc tggacgaatc ccactctggg gtggcgtcct
601 catcaccatc gtggacacct tcttcttcct cttcctcgat aactacgggc tgcggaagct
661 ggaagctttt tttggactcc ttataaccat tatggccttg acctttggct atgagtatgt
721 ggtggcgcgt cctgagcagg gagcgcttct tcggggcctg ttcctgccct cgtgcccggg
781 ctgcggccac cccgagctgc tgcaggcggt gggcattgtt ggcgccatca tcatgcccca
841 caacatctac ctgcactcgg ccctggtcaa gtctcgagag atagaccggg cccgccgagc
901 ggacatcaga gaagccaaca tgtacttcct gattgaggcc accatcgccc tgtccgtctc
961 ctttatcatc aacctctttg tcatggctgt ctttgggcag gccttctacc agaaaaccaa
1021 ccaggctgcg ttcaacatct gtgccaacag cagcctccac gactacgcca agatcttccc
1081 catgaacaac gccaccgtgg ccgtggacat ttaccagggg ggcgtgatcc tgggctgcct
1141 gttcggcccc gcggccctct acatctgggc cataggtctc ctggcggctg ggcagagctc
1201 caccatgacg ggcacctacg cgggacagtt cgtgatggag ggcttcctga ggctgcggtg
1261 gtcacgcttc gcccgtgtcc tcctcacccg ctcctgcgcc atcctgccca ccgtgctcgt
1321 ggctgtcttc cgggacctga gggacttgtc gggcctcaat gatctgctca acgtgctgca
1381 gagcctgctg ctcccgttcg ccgtgctgcc catcctcacg ttcaccagca tgcccaccct
1441 catgcaggag tttgccaatg gcctgctgaa caaggtcgtc acctcttcca tcatggtgct
1501 agtctgcgcc atcaacctct acttcgtggt cagctatctg cccagcctgc cccaccctgc
1561 ctacttcggc cttgcagcct tgctggccgc agcctacctg ggcctcagca cctacctggt
1621 ctggacctgt tgccttgccc acggagccac ctttctggcc cacagctccc accaccactt
1681 cctgtatggg ctccttgaag aggaccagaa aggggagacc tctggctagg cccacaccag
1741 ggcctggctg ggagtggcat gtatgacgtg actggcctgc tggatgtgga gggggcgcgt
1801 gcaggcagca ggatagagtg ggacagttcc tgagaccagc caacctgggg gctttaggga
1861 cctgctgttt cctagcgcag ccatgtgatt accctctggg tctcagtgtc ctcatctgta
1921 aaatggagac accaccaccc ttgccatgga ggttaagcac tttaacacag tgtctggcac
1981 ttgggacaaa aacaaacaaa cgaaaaa
//