LOCUS HUMCACNL1E 7417 bp mRNA linear HUM 03-OCT-2001
DEFINITION Homo sapiens cardiac L-type voltage-dependent calcium channel a1
subunit (CACNL1A1) mRNA, complete cds.
ACCESSION L29534
VERSION L29534.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7417)
AUTHORS Klockner,U., Mikala,G., Eisfeld,J., Iles,D.E., Strobeck,M.,
Mershon,J.L., Schwartz,A. and Varadi,G.
TITLE Properties of three COOH-terminal splice variants of a human
cardiac L-type Ca2+-channel alpha1-subunit
JOURNAL Am. J. Physiol. 272 (3 Pt 2), H1372-H1381 (1997)
PUBMED 9087614
FEATURES Location/Qualifiers
source 1..7417
/db_xref="H-InvDB:HIT000192827"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13.3"
/tissue_type="heart"
/dev_stage="adult"
gene 1..7417
/gene="CACNL1A1"
CDS 14..6448
/gene="CACNL1A1"
/function="calcium channel"
/experiment="experimental evidence, no additional details
recorded"
/note="L-vdcc a1 subunit"
/codon_start=1
/product="cardiac L-type voltage-dependent calcium channel
a1 subunit"
/protein_id="AAA51900.1"
/db_xref="GDB:G00-126-094"
/translation="MNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATI
STVSSTQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIIL
LTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNA
YLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRL
VSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA
DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME
GWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDF
QKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENV
AGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLN
TLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFV
VCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIAS
LLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSV
MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE
EEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQ
PNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSS
NNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTI
FTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS
DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGW
PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ
EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNT
ICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIV
IGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTL
LWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVL
LLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAF
LIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRR
IQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQA
NEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGL
VGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFR
RAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTP
SSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSS
NRERHVPVCEDLELRRDSGSAGTQAHCLLLRRANPSRCHSRESQAAMAGQEETSQDET
YEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLG
RRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPF
ATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARR
VRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACD
MTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEE
ELQDSRVYVSSL"
BASE COUNT 1597 a 2188 c 2061 g 1571 t
ORIGIN
1 tgatcatgcc aacatgaatg ccaatgcggc agcggggctg gcccctgagc acatccccac
61 cccgggggct gccctgtcgt ggcaggcggc catcgacgca gcccggcagg ctaagctgat
121 gggcagcgct ggcaatgcga ccatctccac agtcagctcc acgcagcgga agcggcggca
181 atatgggaaa cccaagaagc agggcagcac cacggccaca cgcccgcccc gagccctgct
241 ctgcctgacc ctgaagaacc ccatccggag ggcctgcatc agcattgtcg aatggaaacc
301 atttgaaata attattttac tgactatttt tgccaattgt gtggccttag cgatctatat
361 tccctttcca gaagatgatt ccaacgccac caattccaac ctggaacgag tggaatatct
421 ctttctcata atttttacgg tggaagcgtt tttaaaagta atcgcctatg gactcctctt
481 tcaccccaat gcctacctcc gcaacggctg gaacctacta gattttataa ttgtggttgt
541 ggggcttttt agtgcaattt tagaacaagc aaccaaagca gatggggcaa acgctctcgg
601 agggaaaggg gccggatttg atgtgaaggc gctgagggcc ttccgcgtgc tgcgccccct
661 gcggctggtg tccggagtcc caagtctcca ggtggtcctg aattccatca tcaaggccat
721 ggtccccctg ctgcacatcg ccctgcttgt gctgtttgtc atcatcatct acgccatcat
781 cggcttggag ctcttcatgg ggaagatgca caagacctgc tacaaccagg agggcatagc
841 agatgttcca gcagaagatg acccttcccc ttgtgcgctg gaaacgggcc acgggcggca
901 gtgccagaac ggcacggtgt gcaagcccgg ctgggatggt cccaagcacg gcatcaccaa
961 ctttgacaac tttgccttcg ccatgctcac ggtgttccag tgcatcacca tggagggctg
1021 gacggacgtg ctgtactgga tgcaggacgc tatgggctat gagttaccct gggtgtattt
1081 tgtcagtctg gtcatctttg gatccttttt cgttctaaat ctggttctcg gtgtgttgag
1141 cggagagttt tccaaagaga gggagaaggc caaggcccgg ggagatttcc agaagctgcg
1201 ggagaagcag cagctagaag aggatctcaa aggctacctg gattggatca ctcaggccga
1261 agacatcgat cctgagaatg aggacgaagg catggatgag gagaagcccc gaaacatgag
1321 catgcccacc agtgagaccg agtccgtcaa caccgaaaac gtggctggag gtgacatcga
1381 gggagaaaac tgcggggcca ggctggccca ccggatctcc aagtcaaagt tcagccgcta
1441 ctggcgccgg tggaatcggt tctgcagaag gaagtgccgc gccgcagtca agtctaatgt
1501 cttctactgg ctggtgattt tcctggtgtt cctcaacacg ctcaccattg cctctgagca
1561 ctacaaccag cccaactggc tcacagaagt ccaagacacg gcaaacaagg ccctgctggc
1621 cctgttcacg gcagagatgc tcctgaagat gtacagcctg ggcctgcagg cctacttcgt
1681 gtccctcttc aaccgctttg actgcttcgt cgtgtgtggc ggcatcctgg agaccatcct
1741 ggtggagacc aagatcatgt ccccactggg catctccgtg ctcagatgcg tccggctgct
1801 gaggattttc aagatcacga ggtactggaa ctccttgagc aacctggtgg catccttgct
1861 gaactctgtg cgctccatcg cctccctgct ccttctcctc ttcctcttca tcatcatctt
1921 ctccctcctg gggatgcagc tctttggagg aaagttcaac tttgatgaga tgcagacccg
1981 gaggagcaca ttcgataact tcccccagtc cctcctcact gtgtttcaga tcctgaccgg
2041 ggaggactgg aattcggtga tgtatgatgg gatcatggct tatggcggcc cctcttttcc
2101 agggatgtta gtctgtattt acttcatcat cctcttcatc tgtggaaact atatcctact
2161 gaatgtgttc ttggccattg ctgtggacaa cctggctgat gctgagagcc tcacatctgc
2221 ccaaaaggag gaggaagagg agaaggagag aaagaagctg gccaggactg ccagcccaga
2281 gaagaaacaa gagttggtgg agaagccggc agtgggggaa tccaaggagg agaagattga
2341 gctgaaatcc atcacggctg acggagagtc tccacccgcc accaagatca acatggatga
2401 cctccagccc aatgaaaatg aggataagag cccctacccc aacccagaaa ctacaggaga
2461 agaggatgag gaggagccag agatgcctgt cggccctcgc ccacgaccac tctctgagct
2521 tcaccttaag gaaaaggcag tgcccatgcc agaagccagc gcgtttttca tcttcagctc
2581 taacaacagg tttcgcctcc agtgccaccg cattgtcaat gacacgatct tcaccaacct
2641 gatcctcttc ttcattctgc tcagcagcat ttccctggct gctgaggacc cggtccagca
2701 cacctccttc aggaaccata ttctgtttta ttttgatatt gtttttacca ccattttcac
2761 cattgaaatt gctctgaaga tgactgctta tggggctttc ttgcacaagg gttctttctg
2821 ccggaactac ttcaacatcc tggacctgct ggtggtcagc gtgtccctca tctcctttgg
2881 catccagtcc agtgcaatca atgtcgtgaa gatcttgcga gtcctgcgag tactcaggcc
2941 cctgagggcc atcaacaggg ccaaggggct aaagcatgtg gttcagtgtg tgtttgtcgc
3001 catccggacc atcgggaaca tcgtgattgt caccaccctg ctgcagttca tgtttgcctg
3061 catcggggtc cagctcttca agggaaagct gtacacctgt tcagacagtt ccaagcagac
3121 agaggcggaa tgcaagggca actacatcac gtacaaagac ggggaggttg accaccccat
3181 catccaaccc cgcagctggg agaacagcaa gtttgacttt gacaatgttc tggcagccat
3241 gatggccctc ttcaccgtct ccaccttcga agggtggcca gagctgctgt accgctccat
3301 cgactcccac acggaagaca agggccccat ctacaactac cgtgtggaga tctccatctt
3361 cttcatcatc tacatcatca tcatcgcctt cttcatgatg aacatcttcg tgggcttcgt
3421 catcgtcacc tttcaggagc agggggagca ggagtacaag aactgtgagc tggacaagaa
3481 ccagcgacag tgcgtggaat acgccctcaa ggcccggccc ctgcggaggt acatccccaa
3541 gaaccagcac cagtacaaag tgtggtacgt ggtcaactcc acctacttcg agtacctgat
3601 gttcgtcctc atcctgctca acaccatctg cctggccatg cagcactacg gccagagctg
3661 cctgttcaaa atcgccatga acatcctcaa catgctcttc actggcctct ttaccgtgga
3721 gatgatcctg aagctcattg ccttcaaacc caagggttac tttagtgatc cctggaatgt
3781 ttttgacttc ctcatcgtaa ttggcagcat aattgacgtc attctcagtg agactaatcc
3841 agctgaacat acccaatgct ctccctctat gaacgcagag gaaaactccc gcatctccat
3901 caccttcttc cgcctgttcc gggtcatgcg tctggtgaag ctgctgagcc gtggggaggg
3961 catccggacg ctgctgtgga ccttcatcaa gtccttccag gccctgccct atgtggccct
4021 cctgatcgtg atgctgttct tcatctacgc ggtgatcggg atgcaggtgt ttgggaaaat
4081 tgccctgaat gataccacag agatcaaccg gaacaacaac tttcagacct tcccccaggc
4141 cgtgctgctc ctcttcaggt gtgccaccgg ggaggcctgg caggacatca tgctggcctg
4201 catgccaggc aagaagtgtg ccccagagtc cgagcccagc aacagcacgg agggtgaaac
4261 accctgtggt agcagctttg ctgtcttcta cttcatcagc ttctacatgc tctgtgcctt
4321 cctgatcatc aacctctttg tagctgtcat catggacaac tttgactacc tgacaaggga
4381 ctggtccatc cttggtcccc accacctgga tgagtttaaa agaatctggg cagagtatga
4441 ccctgaagcc aagggtcgta tcaaacacct ggatgtggtg accctcctcc ggcggattca
4501 gccgccacta ggttttggga agctgtgccc tcaccgcgtg gcttgcaaac gcctggtctc
4561 catgaacatg cctctgaaca gcgacgggac agtcatgttc aatgccaccc tgtttgccct
4621 ggtcaggacg gccctgagga tcaaaacaga agggaaccta gaacaagcca atgaggagct
4681 gcgggcgatc atcaagaaga tctggaagcg gaccagcatg aagctgctgg accaggtggt
4741 gccccctgca ggtgatgatg aggtcaccgt tggcaagttc tacgccacgt tcctgatcca
4801 ggagtacttc cggaagttca agaagcgcaa agagcagggc cttgtgggca agccctccca
4861 gaggaacgcg ctgtctctgc aggctggctt gcgcacactg catgacatcg ggcctgagat
4921 ccgacgggcc atctctggag atctcaccgc tgaggaggag ctggacaagg ccatgaagga
4981 ggctgtgtcc gctgcttctg aagatgacat cttcaggagg gccggtggcc tgttcggcaa
5041 ccacgtcagc tactaccaaa gcgacggccg gagcgccttc ccccagacct tcaccactca
5101 gcgcccgctg cacatcaaca aggcgggcag cagccagggc gacactgagt cgccatccca
5161 cgagaagctg gtggactcca ccttcacccc gagcagctac tcgtccaccg gctccaacgc
5221 caacatcaac aacgccaaca acaccgccct gggtcgcctc cctcgccccg ccggctaccc
5281 cagcacagtc agcactgtgg agggccacgg gccccccttg tcccctgcca tccgggtgca
5341 ggaggtggcg tggaagctca gctccaacag ggaaaggcac gttccggtgt gtgaggatct
5401 ggagctcagg agggattcag gctcagcagg gactcaggct cactgccttc tgctcaggag
5461 agcaaacccc tctaggtgcc actcccggga gagccaggca gccatggcgg gtcaggagga
5521 gacgtctcag gatgagacct atgaagtgaa gatgaaccat gacacggagg cctgcagtga
5581 gcccagcctg ctctccacag agatgctctc ctaccaggat gacgaaaatc ggcaactgac
5641 gctcccagag gaggacaaga gggacatccg gcaatctccg aagaggggtt tcctccgctc
5701 tgcctcacta ggtcgaaggg cctccttcca cctggaatgt ctgaagcgac agaaggaccg
5761 agggggagac atctctcaga agacagtcct gcccttgcat ctggttcatc atcaggcatt
5821 ggcagtggca ggcctgagcc ccctcctcca gagaagccat tcccctgcct cattccctag
5881 gccttttgcc accccaccag ccacacctgg cagccgaggc tggcccccac agcccgtccc
5941 caccctgcgg cttgaggggg tcgagtccag tgagaaactc aacagcagct tcccatccat
6001 ccactgcggc tcctgggctg agaccacccc cggtggcggg ggcagcagcg ccgcccggag
6061 agtccggccc gtctccctca tggtgcccag ccaggctggg gccccaggga ggcagttcca
6121 cggcagtgcc agcagcctgg tggaagcggt cttgatttca gaaggactgg ggcagtttgc
6181 tcaagatccc aagttcatcg aggtcaccac ccaggagctg gccgacgcct gcgacatgac
6241 catagaggag atggagagcg cggccgacaa catcctcagc gggggcgccc cacagagccc
6301 caatggcgcc ctcttaccct ttgtgaactg cagggacgcg gggcaggacc gagccggggg
6361 cgaagaggac gcgggctgtg tgcgcgcgcg gggtcgaccg agtgaggagg agctccagga
6421 cagcagggtc tacgtcagca gcctgtagtg ggcgctgcca gatgcgggct tttttttatt
6481 tgtttcaatg ttcctaatgg gttcgtttca gaagtgcctc actgttctcg tgacctggag
6541 ttaaccggaa cagcgtcttc attcatttct gttgggacca gacgcggagc ctgggtgcgc
6601 gagccgccct ccgggaggaa ggcgcccggc tgcgtctgca gaggcgggga gaggaggcgg
6661 cgagggtccc ggggcgcgag gaaggcgctg ccctctccca gctcgcaggc cccgggccgg
6721 ccgcgcctct gcgggagagc accccggctt cccgcgcgcc ctcaccaaaa ggaccctaca
6781 gcaaacgggg tctttcgact ctgcttgtag aaaccatttg cacatattct gtacgagcct
6841 gctgtctccc tagagccagg gccctgcgga tttggagaag ggagcggggc aggacttcca
6901 ggaggacccc aacccggccc ggagagggag gaggaggcct ccaggggcgc ggagctctgg
6961 ggatgggcgt cgggccggca gtggtgcggc tcactccgtc cctgcccacc tgcgacggga
7021 tcccccgacc ggcacggcca cgccgagctc ccggccagcc gccggcccgc aggcagcgcg
7081 agggaggagc tgcgccgccg ggccggggcc gccggctccg cccaaccagg tggtgctgag
7141 cttccgctga gcgctctttt gttttgtggt ttgacacttt tgttgacagc atgttgcagt
7201 ttcttttcgg ttttggtttt ttttaaatgt tttattttgc tttcccagcg ggaggggagg
7261 aagaagagtg tttacaaagt cctgtagccc cctcaccttt cctgttttca cttttgccaa
7321 tgtacatcgg gtttggtttt cttgtattat ttaaacggtt gtggtttcct ttttccacgg
7381 aggttcaata aaagccgctg caggagagtt ttaccaa
//