LOCUS HUMCACN 7499 bp mRNA linear HUM 31-OCT-1994
DEFINITION Homo sapiens (clone HHT-1 variant harboring HH-05) cardiac L-type
voltage dependent calcium channel alpha 1 subunit (CACNL1A1) mRNA,
complete cds.
ACCESSION L29529
VERSION L29529.1
KEYWORDS voltage-dependent calcium channel; voltage-dependent calcium
channel alpha 1 subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7499)
AUTHORS Schultz,D., Mikala,G., Yatani,A., Engle,D.B., Iles,D.E., Segers,B.,
Sinke,R.J., Olde Weghuis,D., Klockner,U., Wang,J.-J., Varadi,G. and
Schwartz,A.
TITLE Cloning, chromosomal localization, and functional expression of the
alpha 1 subunit of the L-type voltage-dependent calcium channel
from normal human heart
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (13), 6228-6232 (1993)
PUBMED 8392192
COMMENT Original source text: Homo sapiens (tissue library: lambda ZAP)
adult heart cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..7499
/db_xref="H-InvDB:HIT000192826"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="12p13.3"
/tissue_type="heart"
/dev_stage="adult"
/tissue_lib="lambda ZAP"
gene 1..7499
/gene="CACNL1A1"
5'UTR 1..19
/gene="CACNL1A1"
/note="G00-126-094"
CDS 20..6529
/gene="CACNL1A1"
/function="cardiac calcium channel, excitation-contraction
coupling"
/standard_name="L-VDCC a1"
/experiment="experimental evidence, no additional details
recorded"
/note="this clone is a full-length human cardiac calcium
channel isoform, a splice variant of hht-1 having
different motif IV S3 region and an 11 amino acid deletion
immediately afterwards"
/codon_start=1
/product="L-type voltage-dependent cardiac calcium channel
alpha 1 subunit"
/protein_id="AAA51899.1"
/db_xref="GDB:G00-126-094"
/translation="MNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATI
STVSSTQRKRRQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIIL
LTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNA
YLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRL
VSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIA
DVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME
GWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDF
QKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENV
AGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLN
TLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFV
VCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIAS
LLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSV
MYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEE
EEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQ
PNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSS
NNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTI
FTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCS
DSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGW
PELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQ
EYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNT
ICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIV
VGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQAL
PYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAW
QDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIM
DNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC
PHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKI
WKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALS
LQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVS
YYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNAN
INNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRMHCCDMLDG
GTFPPALGPRRAPPCLHQQLQGSLAGLREDTPCIVPGHASLCCSSRVGEWLPAGCTAP
QHARCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQL
TLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHH
QALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNS
SFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLIS
EGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCR
DAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL"
3'UTR 6530..7499
/gene="CACNL1A1"
/note="G00-126-094"
BASE COUNT 1601 a 2226 c 2091 g 1581 t
ORIGIN
1 tctagctgat catgccaaca tgaatgccaa tgcggcagcg gggctggccc ctgagcacat
61 ccccaccccg ggggctgccc tgtcgtggca ggcggccatc gacgcagccc ggcaggctaa
121 gctgatgggc agcgctggca atgcgaccat ctccacagtc agctccacgc agcggaagcg
181 gcggcaatat gggaaaccca agaagcaggg cagcaccacg gccacacgcc cgccccgagc
241 cctgctctgc ctgaccctga agaaccccat ccggagggcc tgcatcagca ttgtcgaatg
301 gaaaccattt gaaataatta ttttactgac tatttttgcc aattgtgtgg ccttagcgat
361 ctatattccc tttccagaag atgattccaa cgccaccaat tccaacctgg aacgagtgga
421 atatctcttt ctcataattt ttacggtgga agcgttttta aaagtaatcg cctatggact
481 cctctttcac cccaatgcct acctccgcaa cggctggaac ctactagatt ttataattgt
541 ggttgtgggg ctttttagtg caattttaga acaagcaacc aaagcagatg gggcaaacgc
601 tctcggaggg aaaggggccg gatttgatgt gaaggcgctg agggccttcc gcgtgctgcg
661 ccccctgcgg ctggtgtccg gagtcccaag tctccaggtg gtcctgaatt ccatcatcaa
721 ggccatggtc cccctgctgc acatcgccct gcttgtgctg tttgtcatca tcatctacgc
781 catcatcggc ttggagctct tcatggggaa gatgcacaag acctgctaca accaggaggg
841 catagcagat gttccagcag aagatgaccc ttccccttgt gcgctggaaa cgggccacgg
901 gcggcagtgc cagaacggca cggtgtgcaa gcccggctgg gatggtccca agcacggcat
961 caccaacttt gacaactttg ccttcgccat gctcacggtg ttccagtgca tcaccatgga
1021 gggctggacg gacgtgctgt actggatgca ggacgctatg ggctatgagt taccctgggt
1081 gtattttgtc agtctggtca tctttggatc ctttttcgtt ctaaatctgg ttctcggtgt
1141 gttgagcgga gagttttcca aagagaggga gaaggccaag gcccggggag atttccagaa
1201 gctgcgggag aagcagcagc tagaagagga tctcaaaggc tacctggatt ggatcactca
1261 ggccgaagac atcgatcctg agaatgagga cgaaggcatg gatgaggaga agccccgaaa
1321 catgagcatg cccaccagtg agaccgagtc cgtcaacacc gaaaacgtgg ctggaggtga
1381 catcgaggga gaaaactgcg gggccaggct ggcccaccgg atctccaagt caaagttcag
1441 ccgctactgg cgccggtgga atcggttctg cagaaggaag tgccgcgccg cagtcaagtc
1501 taatgtcttc tactggctgg tgattttcct ggtgttcctc aacacgctca ccattgcctc
1561 tgagcactac aaccagccca actggctcac agaagtccaa gacacggcaa acaaggccct
1621 gctggccctg ttcacggcag agatgctcct gaagatgtac agcctgggcc tgcaggccta
1681 cttcgtgtcc ctcttcaacc gctttgactg cttcgtcgtg tgtggcggca tcctggagac
1741 catcctggtg gagaccaaga tcatgtcccc actgggcatc tccgtgctca gatgcgtccg
1801 gctgctgagg attttcaaga tcacgaggta ctggaactcc ttgagcaacc tggtggcatc
1861 cttgctgaac tctgtgcgct ccatcgcctc cctgctcctt ctcctcttcc tcttcatcat
1921 catcttctcc ctcctgggga tgcagctctt tggaggaaag ttcaactttg atgagatgca
1981 gacccggagg agcacattcg ataacttccc ccagtccctc ctcactgtgt ttcagatcct
2041 gaccggggag gactggaatt cggtgatgta tgatgggatc atggcttatg gcggcccctc
2101 ttttccaggg atgttagtct gtatttactt catcatcctc ttcatctgtg gaaactatat
2161 cctactgaat gtgttcttgg ccattgctgt ggacaacctg gctgatgctg agagcctcac
2221 atctgcccaa aaggaggagg aagaggagaa ggagagaaag aagctggcca ggactgccag
2281 cccagagaag aaacaagagt tggtggagaa gccggcagtg ggggaatcca aggaggagaa
2341 gattgagctg aaatccatca cggctgacgg agagtctcca cccgccacca agatcaacat
2401 ggatgacctc cagcccaatg aaaatgagga taagagcccc taccccaacc cagaaactac
2461 aggagaagag gatgaggagg agccagagat gcctgtcggc cctcgcccac gaccactctc
2521 tgagcttcac cttaaggaaa aggcagtgcc catgccagaa gccagcgcgt ttttcatctt
2581 cagctctaac aacaggtttc gcctccagtg ccaccgcatt gtcaatgaca cgatcttcac
2641 caacctgatc ctcttcttca ttctgctcag cagcatttcc ctggctgctg aggacccggt
2701 ccagcacacc tccttcagga accatattct gttttatttt gatattgttt ttaccaccat
2761 tttcaccatt gaaattgctc tgaagatgac tgcttatggg gctttcttgc acaagggttc
2821 tttctgccgg aactacttca acatcctgga cctgctggtg gtcagcgtgt ccctcatctc
2881 ctttggcatc cagtccagtg caatcaatgt cgtgaagatc ttgcgagtcc tgcgagtact
2941 caggcccctg agggccatca acagggccaa ggggctaaag catgtggttc agtgtgtgtt
3001 tgtcgccatc cggaccatcg ggaacatcgt gattgtcacc accctgctgc agttcatgtt
3061 tgcctgcatc ggggtccagc tcttcaaggg aaagctgtac acctgttcag acagttccaa
3121 gcagacagag gcggaatgca agggcaacta catcacgtac aaagacgggg aggttgacca
3181 ccccatcatc caaccccgca gctgggagaa cagcaagttt gactttgaca atgttctggc
3241 agccatgatg gccctcttca ccgtctccac cttcgaaggg tggccagagc tgctgtaccg
3301 ctccatcgac tcccacacgg aagacaaggg ccccatctac aactaccgtg tggagatctc
3361 catcttcttc atcatctaca tcatcatcat cgccttcttc atgatgaaca tcttcgtggg
3421 cttcgtcatc gtcacctttc aggagcaggg ggagcaggag tacaagaact gtgagctgga
3481 caagaaccag cgacagtgcg tggaatacgc cctcaaggcc cggcccctgc ggaggtacat
3541 ccccaagaac cagcaccagt acaaagtgtg gtacgtggtc aactccacct acttcgagta
3601 cctgatgttc gtcctcatcc tgctcaacac catctgcctg gccatgcagc actacggcca
3661 gagctgcctg ttcaaaatcg ccatgaacat cctcaacatg ctcttcactg gcctctttac
3721 cgtggagatg atcctgaagc tcattgcctt caaacccaag cactacttct gtgatgcatg
3781 gaatacattt gacgccttga ttgttgtggg tagcattgtt gatatagcaa tcaccgaggt
3841 aaacaacgca gaggaaaact cccgcatctc catcaccttc ttccgcctgt tccgggtcat
3901 gcgtctggtg aagctgctga gccgtgggga gggcatccgg acgctgctgt ggaccttcat
3961 caagtccttc caggccctgc cctatgtggc cctcctgatc gtgatgctgt tcttcatcta
4021 cgcggtgatc gggatgcagg tgtttgggaa aattgccctg aatgatacca cagagatcaa
4081 ccggaacaac aactttcaga ccttccccca ggccgtgctg ctcctcttca ggtgtgccac
4141 cggggaggcc tggcaggaca tcatgctggc ctgcatgcca ggcaagaagt gtgccccaga
4201 gtccgagccc agcaacagca cggagggtga aacaccctgt ggtagcagct ttgctgtctt
4261 ctacttcatc agcttctaca tgctctgtgc cttcctgatc atcaacctct ttgtagctgt
4321 catcatggac aactttgact acctgacaag ggactggtcc atccttggtc cccaccacct
4381 ggatgagttt aaaagaatct gggcagagta tgaccctgaa gccaagggtc gtatcaaaca
4441 cctggatgtg gtgaccctcc tccggcggat tcagccgcca ctaggttttg ggaagctgtg
4501 ccctcaccgc gtggcttgca aacgcctggt ctccatgaac atgcctctga acagcgacgg
4561 gacagtcatg ttcaatgcca ccctgtttgc cctggtcagg acggccctga ggatcaaaac
4621 agaagggaac ctagaacaag ccaatgagga gctgcgggcg atcatcaaga agatctggaa
4681 gcggaccagc atgaagctgc tggaccaggt ggtgccccct gcaggtgatg atgaggtcac
4741 cgttggcaag ttctacgcca cgttcctgat ccaggagtac ttccggaagt tcaagaagcg
4801 caaagagcag ggccttgtgg gcaagccctc ccagaggaac gcgctgtctc tgcaggctgg
4861 cttgcgcaca ctgcatgaca tcgggcctga gatccgacgg gccatctctg gagatctcac
4921 cgctgaggag gagctggaca aggccatgaa ggaggctgtg tccgctgctt ctgaagatga
4981 catcttcagg agggccggtg gcctgttcgg caaccacgtc agctactacc aaagcgacgg
5041 ccggagcgcc ttcccccaga ccttcaccac tcagcgcccg ctgcacatca acaaggcggg
5101 cagcagccag ggcgacactg agtcgccatc ccacgagaag ctggtggact ccaccttcac
5161 cccgagcagc tactcgtcca ccggctccaa cgccaacatc aacaacgcca acaacaccgc
5221 cctgggtcgc ctccctcgcc ccgccggcta ccccagcaca gtcagcactg tggagggcca
5281 cgggcccccc ttgtcccctg ccatccgggt gcaggaggtg gcgtggaagc tcagctccaa
5341 caggatgcac tgctgtgaca tgctggatgg tgggaccttc cctcccgccc tgggcccccg
5401 cagggctcct ccctgtctgc atcagcagct ccagggttcc ctggcggggc tgagagagga
5461 cacaccctgc atcgtgcctg gccacgcttc actgtgctgc tcttccagag taggagagtg
5521 gctcccagca ggctgcacag ccccccagca tgccaggtgc cactcccggg agagccaggc
5581 agccatggcg ggtcaggagg agacgtctca ggatgagacc tatgaagtga agatgaacca
5641 tgacacggag gcctgcagtg agcccagcct gctctccaca gagatgctct cctaccagga
5701 tgacgaaaat cggcaactga cgctcccaga ggaggacaag agggacatcc ggcaatctcc
5761 gaagaggggt ttcctccgct ctgcctcact aggtcgaagg gcctccttcc acctggaatg
5821 tctgaagcga cagaaggacc gagggggaga catctctcag aagacagtcc tgcccttgca
5881 tctggttcat catcaggcat tggcagtggc aggcctgagc cccctcctcc agagaagcca
5941 ttcccctgcc tcattcccta ggccttttgc caccccacca gccacacctg gcagccgagg
6001 ctggccccca cagcccgtcc ccaccctgcg gcttgagggg gtcgagtcca gtgagaaact
6061 caacagcagc ttcccatcca tccactgcgg ctcctgggct gagaccaccc ccggtggcgg
6121 gggcagcagc gccgcccgga gagtccggcc cgtctccctc atggtgccca gccaggctgg
6181 ggccccaggg aggcagttcc acggcagtgc cagcagcctg gtggaagcgg tcttgatttc
6241 agaaggactg gggcagtttg ctcaagatcc caagttcatc gaggtcacca cccaggagct
6301 ggccgacgcc tgcgacatga ccatagagga gatggagagc gcggccgaca acatcctcag
6361 cgggggcgcc ccacagagcc ccaatggcgc cctcttaccc tttgtgaact gcagggacgc
6421 ggggcaggac cgagccgggg gcgaagagga cgcgggctgt gtgcgcgcgc ggggtcgacc
6481 gagtgaggag gagctccagg acagcagggt ctacgtcagc agcctgtagt gggcgctgcc
6541 agatgcgggc ttttttttat ttgtttcaat gttcctaatg ggttcgtttc agaagtgcct
6601 cactgttctc gtgacctgga gttaaccgga acagcgtctt cattcatttc tgttgggacc
6661 agacgcggag cctgggtgcg cgagccgccc tccgggagga aggcgcccgg ctgcgtctgc
6721 agaggcgggg agaggaggcg gcgagggtcc cggggcgcga ggaaggcgct gccctctccc
6781 agctcgcagg ccccgggccg gccgcgcctc tgcgggagag caccccggct tcccgcgcgc
6841 cctcaccaaa aggaccctac agcaaacggg gtctttcgac tctgcttgta gaaaccattt
6901 gcacatattc tgtacgagcc tgctgtctcc ctagagccag ggccctgcgg atttggagaa
6961 gggagcgggg caggacttcc aggaggaccc caacccggcc cggagaggga ggaggaggcc
7021 tccaggggcg cggagctctg gggatgggcg tcgggccggc agtggtgcgg ctcactccgt
7081 ccctgcccac ctgcgacggg atcccccgac cggcacggcc acgccgagct cccggccagc
7141 cgccggcccg caggcagcgc gagggaggag ctgcgccgcc gggccggggc cgccggctcc
7201 gcccaaccag gtggtgctga gcttccgctg agcgctcttt tgttttgtgg tttgacactt
7261 ttgttgacag catgttgcag tttcttttcg gttttggttt tttttaaatg ttttattttg
7321 ctttcccagc gggaggggag gaagaagagt gtttacaaag tcctgtagcc ccctcacctt
7381 tcctgttttc acttttgcca atgtacatcg ggtttggttt tcttgtatta tttaaacggt
7441 tgtggtttcc tttttccacg gaggttcaag taaagccgct gcaggagagt tttaccaaa
//