LOCUS       L29394                  1411 bp    mRNA    linear   HUM 04-AUG-2004
DEFINITION  Homo sapiens haptoglobin alpha(2FS)-beta precursor (HP) mRNA,
            complete cds.
ACCESSION   L29394 M12387 N00026 X00442
VERSION     L29394.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   van der Straten,A., Herzog,A., Cabezon,T. and Bollen,A.
  TITLE     Characterization of human haptoglobin cDNAs coding for alpha 2FS
            beta and alpha 1S beta variants
  JOURNAL   FEBS Lett. 168 (1), 103-107 (1984)
   PUBMED   6546723
COMMENT     On Aug 4, 2004 this sequence version replaced X00442.1.
            Data kindly reviewed (23-MAY-1984) by A. van der Straten. Hp mRNA
            codes for both alpha and beta polypeptides in tandem. The two
            chains are linked on the alpha-beta precursor by a single Arg
            residue (507-509), which is released during the proteolytic
            maturation generating the alpha and beta subunits. This cleavage
            mechanism gives further support to the hypothesis of a common
            ancestor for Hp and the serine protease family. Inherited
            variations in the smaller subunit, the alpha chain, are responsible
            for Hp polymorphism in human populations, the alpha chain having
            two major allelic forms, alpha-1 with 83 residues and alpha-2 with
            142 residues. These alleles determine the 3 major phenotypes Hp1-1,
            Hp2-2 and Hp2-1.
            An Hp-alpha(1S)-beta variant was also presented in [1]; the DNA
            sequences are identical except for the Ala 11 to Glu 69 (111-287)
            duplicated portion of alpha-2.
FEATURES             Location/Qualifiers
     source          1..1411
                     /db_xref="H-InvDB:HIT000192823"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
                     /clone="pULB1148"
                     /haplotype="heterozygous Hp2-1"
                     /tissue_type="liver"
     gene            1..1411
                     /gene="HP"
     CDS             27..1247
                     /gene="HP"
                     /note="preprohaptoglobin"
                     /codon_start=1
                     /product="haptoglobin alpha(2FS)-beta precursor"
                     /protein_id="AAA52685.1"
                     /db_xref="GDB:G00-119-314"
                     /translation="MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYV
                     EHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGY
                     VEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQ
                     RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIA
                     PTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVG
                     RVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL
                     NEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKV
                     TSIQDWVQKTIAEN"
     sig_peptide     27..80
                     /gene="HP"
     misc_feature    81..1244
                     /gene="HP"
                     /note="encodes haptoglobin alpha(2FS)-beta proprotein"
     mat_peptide     81..506
                     /gene="HP"
                     /product="haptoglobin alpha-2FS chain"
     mat_peptide     510..1244
                     /gene="HP"
                     /product="haptoglobin beta chain"
     misc_feature    111..287
                     /gene="HP"
                     /note="duplicated portion of alpha-chain"
     misc_feature    507..509
                     /gene="HP"
                     /note="cleavage site alpha-beta chain"
BASE COUNT          397 a          319 c          384 g          311 t
ORIGIN      
        1 ctcttccaga ggcaagacca accaagatga gtgccttggg agctgtcatt gccctcctgc
       61 tctggggaca gctttttgca gtggactcag gcaatgatgt cacggatatc gcagatgacg
      121 gctgcccgaa gccccccgag attgcacatg gctatgtgga gcactcggtt cgctaccagt
      181 gtaagaacta ctacaaactg cgcacagaag gagatggagt atacacctta aatgataaga
      241 agcagtggat aaataaggct gttggagata aacttcctga atgtgaagca gatgacggct
      301 gcccgaagcc ccccgagatt gcacatggct atgtggagca ctcggttcgc taccagtgta
      361 agaactacta caaactgcgc acagaaggag atggagtgta caccttaaac aatgagaagc
      421 agtggataaa taaggctgtt ggagataaac ttcctgaatg tgaagcagta tgtgggaagc
      481 ccaagaatcc ggcaaaccca gtgcagcgga tcctgggtgg acacctggat gccaaaggca
      541 gctttccctg gcaggctaag atggtttccc accataatct caccacaggt gccacgctga
      601 tcaatgaaca atggctgctg accacggcta aaaatctctt cctgaaccat tcagaaaatg
      661 caacagcgaa agacattgcc cccactttaa cactctatgt ggggaaaaag cagcttgtag
      721 agattgagaa ggttgttcta caccctaact actcccaagt agatattggg ctcatcaaac
      781 tcaaacagaa ggtgtctgtt aatgagagag tgatgcccat ctgcctacca tccaaggatt
      841 atgcagaagt agggcgtgtg ggttatgttt ctggctgggg gcgaaatgcc aattttaaat
      901 ttactgacca tctgaagtat gtcatgctgc ctgtggctga ccaagaccaa tgcataaggc
      961 attatgaagg cagcacagtc cccgaaaaga agacaccgaa gagccctgta ggggtgcagc
     1021 ccatactgaa tgaacacacc ttctgtgctg gcatgtctaa gtaccaagaa gacacctgct
     1081 atggcgatgc gggcagtgcc tttgccgttc acgacctgga ggaggacacc tggtatgcga
     1141 ctgggatctt aagctttgat aagagctgtg ctgtggctga gtatggtgtg tatgtgaagg
     1201 tgacttccat ccaggactgg gttcagaaga ccatagctga gaactaatgc aaggctggcc
     1261 ggaagccctt gcctgaaagc aagatttcag cctggaagag ggcaaagtgg acgggagtgg
     1321 acaggagtgg atgcgataag atgtggtttg aagctgatgg gtgccagccc tgcattgctg
     1381 agtcaatcaa taaagagctt tcttttgacc c
//