LOCUS       HUMINK4X                 987 bp    mRNA    linear   HUM 20-MAR-1996
DEFINITION  Human CDK4-inhibitor (p16-INK4) mRNA, complete cds.
ACCESSION   L27211
VERSION     L27211.1
KEYWORDS    CDK4; cyclin D.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 60 to 987)
  AUTHORS   Serrano,M., Hannon,G.J. and Beach,D.
  TITLE     A new regulatory motif in cell-cycle control causing specific
            inhibition of cyclin D/CDK4
  JOURNAL   Nature 366 (6456), 704-707 (1993)
   PUBMED   8259215
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Okamoto,A., Demetrick,D.J., Spillare,E.A., Hagiwara,K.,
            Hussain,S.P., Bennett,W.P., Forrester,K., Gerwin,B., Serrano,M.,
            Beach,D.H. and Harris,C.C.
  TITLE     Mutations and altered expression of p16INK4 in human cancer
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (23), 11045-11049 (1994)
   PUBMED   7972006
REFERENCE   3  (bases 60 to 987)
  AUTHORS   Serrano,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JAN-1994) Manuel Serrano, Cold Spring Harbor
            Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
REFERENCE   4  (bases 1 to 987)
  AUTHORS   Serrano,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-SEP-1994) Manuel Serrano, Cold Spring Harbor
            Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
COMMENT     On Oct 18, 1994 this sequence version replaced gi:535942.
FEATURES             Location/Qualifiers
     source          1..987
                     /db_xref="H-InvDB:HIT000192716"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="S3"
                     /db_xref="taxon:9606"
                     /cell_line="HeLa"
                     /clone_lib="pGAD-GH low"
     CDS             41..511
                     /function="inhibitor of cyclin-dependent kinase 4"
                     /codon_start=1
                     /product="p16-INK4"
                     /protein_id="AAA92554.1"
                     /translation="MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSY
                     GRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA
                     RLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD"
     repeat_region   74..491
                     /rpt_family="ankyrin"
                     /rpt_unit_range=170..263
                     /rpt_unit_range=269..365
                     /rpt_unit_range=368..491
                     /rpt_unit_range=74..167
BASE COUNT          219 a          279 c          295 g          194 t
ORIGIN      
        1 cggagagggg gagaacagac aacgggcggc ggggagcagc atggagccgg cggcggggag
       61 cagcatggag ccttcggctg actggctggc cacggccgcg gcccggggtc gggtagagga
      121 ggtgcgggcg ctgctggagg cgggggcgct gcccaacgca ccgaatagtt acggtcggag
      181 gccgatccag gtcatgatga tgggcagcgc ccgagtggcg gagctgctgc tgctccacgg
      241 cgcggagccc aactgcgccg accccgccac tctcacccga cccgtgcacg acgctgcccg
      301 ggagggcttc ctggacacgc tggtggtgct gcaccgggcc ggggcgcggc tggacgtgcg
      361 cgatgcctgg ggccgtctgc ccgtggacct ggctgaggag ctgggccatc gcgatgtcgc
      421 acggtacctg cgcgcggctg cggggggcac cagaggcagt aaccatgccc gcatagatgc
      481 cgcggaaggt ccctcagaca tccccgattg aaagaaccag agaggctctg agaaacctcg
      541 ggaaacttag atcatcagtc accgaaggtc ctacagggcc acaactgccc ccgccacaac
      601 ccaccccgct ttcgtagttt tcatttagaa aatagagctt ttaaaaatgt cctgcctttt
      661 aacgtagata taagccttcc cccactaccg taaatgtcca tttatatcat tttttatata
      721 ttcttataaa aatgtaaaaa agaaaaacac cgcttctgcc ttttcactgt gttggagttt
      781 tctggagtga gcactcacgc cctaagcgca cattcatgtg ggcatttctt gcgagcctcg
      841 cagcctccgg aagctgtcga cttcatgaca agcattttgt gaactaggga agctcagggg
      901 ggttactggc ttctcttgag tcacactgct agcaaatggc agaaccaaag ctcaaataaa
      961 aataaaataa ttttcattca ttcactc
//