LOCUS HUMINK4X 987 bp mRNA linear HUM 20-MAR-1996 DEFINITION Human CDK4-inhibitor (p16-INK4) mRNA, complete cds. ACCESSION L27211 VERSION L27211.1 KEYWORDS CDK4; cyclin D. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 60 to 987) AUTHORS Serrano,M., Hannon,G.J. and Beach,D. TITLE A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 JOURNAL Nature 366 (6456), 704-707 (1993) PUBMED 8259215 REFERENCE 2 (bases 1 to 987) AUTHORS Okamoto,A., Demetrick,D.J., Spillare,E.A., Hagiwara,K., Hussain,S.P., Bennett,W.P., Forrester,K., Gerwin,B., Serrano,M., Beach,D.H. and Harris,C.C. TITLE Mutations and altered expression of p16INK4 in human cancer JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (23), 11045-11049 (1994) PUBMED 7972006 REFERENCE 3 (bases 60 to 987) AUTHORS Serrano,M. TITLE Direct Submission JOURNAL Submitted (02-JAN-1994) Manuel Serrano, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA REFERENCE 4 (bases 1 to 987) AUTHORS Serrano,M. TITLE Direct Submission JOURNAL Submitted (01-SEP-1994) Manuel Serrano, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA COMMENT On Oct 18, 1994 this sequence version replaced gi:535942. FEATURES Location/Qualifiers source 1..987 /db_xref="H-InvDB:HIT000192716" /organism="Homo sapiens" /mol_type="mRNA" /isolate="S3" /db_xref="taxon:9606" /cell_line="HeLa" /clone_lib="pGAD-GH low" CDS 41..511 /function="inhibitor of cyclin-dependent kinase 4" /codon_start=1 /product="p16-INK4" /protein_id="AAA92554.1" /translation="MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSY GRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA RLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD" repeat_region 74..491 /rpt_family="ankyrin" /rpt_unit_range=170..263 /rpt_unit_range=269..365 /rpt_unit_range=368..491 /rpt_unit_range=74..167 BASE COUNT 219 a 279 c 295 g 194 t ORIGIN 1 cggagagggg gagaacagac aacgggcggc ggggagcagc atggagccgg cggcggggag 61 cagcatggag ccttcggctg actggctggc cacggccgcg gcccggggtc gggtagagga 121 ggtgcgggcg ctgctggagg cgggggcgct gcccaacgca ccgaatagtt acggtcggag 181 gccgatccag gtcatgatga tgggcagcgc ccgagtggcg gagctgctgc tgctccacgg 241 cgcggagccc aactgcgccg accccgccac tctcacccga cccgtgcacg acgctgcccg 301 ggagggcttc ctggacacgc tggtggtgct gcaccgggcc ggggcgcggc tggacgtgcg 361 cgatgcctgg ggccgtctgc ccgtggacct ggctgaggag ctgggccatc gcgatgtcgc 421 acggtacctg cgcgcggctg cggggggcac cagaggcagt aaccatgccc gcatagatgc 481 cgcggaaggt ccctcagaca tccccgattg aaagaaccag agaggctctg agaaacctcg 541 ggaaacttag atcatcagtc accgaaggtc ctacagggcc acaactgccc ccgccacaac 601 ccaccccgct ttcgtagttt tcatttagaa aatagagctt ttaaaaatgt cctgcctttt 661 aacgtagata taagccttcc cccactaccg taaatgtcca tttatatcat tttttatata 721 ttcttataaa aatgtaaaaa agaaaaacac cgcttctgcc ttttcactgt gttggagttt 781 tctggagtga gcactcacgc cctaagcgca cattcatgtg ggcatttctt gcgagcctcg 841 cagcctccgg aagctgtcga cttcatgaca agcattttgt gaactaggga agctcagggg 901 ggttactggc ttctcttgag tcacactgct agcaaatggc agaaccaaag ctcaaataaa 961 aataaaataa ttttcattca ttcactc //