LOCUS HUMEPOHYDA 1704 bp mRNA linear HUM 07-NOV-1994
DEFINITION Homo sapiens p33/HEH epoxide hydrolase (EPHX) mRNA, complete cds.
ACCESSION L25878
VERSION L25878.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1704)
AUTHORS Hassett,C., Aicher,L., Sidhu,J.S. and Omiecinski,C.J.
TITLE Human microsomal epoxide hydrolase: genetic polymorphism and
functional expression in vitro of amino acid variants
JOURNAL Hum. Mol. Genet. 3 (3), 421-428 (1994)
PUBMED 7516776
COMMENT Original source text: Homo sapiens (tissue library: lambda gt11
obtained from Clontech) female adult liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1704
/db_xref="H-InvDB:HIT000192648"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p11-qter"
/sex="female"
/tissue_type="liver"
/dev_stage="adult"
/tissue_lib="lambda gt11 obtained from Clontech"
gene 1..1704
/gene="EPHX"
CDS 124..1491
/gene="EPHX"
/EC_number="3.3.2.9"
/note="note polymorphic Ile396"
/codon_start=1
/product="epoxide hydrolase"
/protein_id="AAA52389.1"
/db_xref="GDB:G00-119-876"
/translation="MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAARE
DDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFD
WKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKI
IPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQ
EFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTE
RDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTN
TEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKV
YVPIGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLS
VLERQ"
regulatory 1489..1491
/regulatory_class="terminator"
/gene="EPHX"
regulatory 1686..1691
/regulatory_class="polyA_signal_sequence"
/gene="EPHX"
/note="note noncanonical poly A sequence"
BASE COUNT 377 a 503 c 438 g 386 t
ORIGIN
1 cgtggagcct ggtggacagg tgaaagcact gggatctttc tgcccagaaa ggggaaagtt
61 gcacatttat atcctagagg gaagcgacag cagtgcttct ccctgtgctg aggtacagga
121 gccatgtggc tagaaatcct cctcacttca gtgctgggct ttgccatcta ctggttcatc
181 tcccgggaca aagaggaaac tttgccactt gaagatgggt ggtgggggcc aggcacgagg
241 tccgcagcca gggaggacga cagcatccgc cctttcaagg tggaaacgtc agatgaggag
301 atccacgact tacaccagag gatcgataag ttccgtttca ccccaccttt ggaggacagc
361 tgcttccact atggcttcaa ctccaactac ctgaagaaag tcatctccta ctggcggaat
421 gaatttgact ggaagaagca ggtggagatt ctcaacagat accctcactt caagactaaa
481 attgaagggc tggacatcca cttcatccac gtgaagcccc cccagctgcc cgcaggccat
541 accccgaagc ccttgctgat ggtgcacggc tggcccggct ctttctacga gttttataag
601 atcatcccac tcctgactga ccccaagaac catggcctga gcgatgagca cgtttttgaa
661 gtcatctgcc cttccatccc tggctatggc ttctcagagg catcctccaa gaaggggttc
721 aactcggtgg ccaccgccag gatcttttac aagctgatgc tgcggctggg cttccaggaa
781 ttctacattc aaggagggga ctgggggtcc ctgatctgca ctaatatggc ccagctggtg
841 cccagccacg tgaaaggcct gcacttgaac atggctttgg ttttaagcaa cttctctacc
901 ctgaccctcc tcctgggaca gcgtttcggg aggtttcttg gcctcactga gagggatgtg
961 gagctgctgt accccgtcaa ggagaaggta ttctacagcc tgatgaggga gagcggctac
1021 atgcacatcc agtgcaccaa gcctgacacc gtaggctctg ctctgaatga ctctcctgtg
1081 ggtctggctg cctatattct agagaagttt tccacctgga ccaatacgga attccgatac
1141 ctggaggatg gaggcctgga aaggaagttc tccctggacg acctgctgac caacgtcatg
1201 ctctactgga caacaggcac catcatctcc tcccagcgct tctacaagga gaacctggga
1261 cagggctgga tgacccagaa gcatgagcgg atgaaggtct atgtgcccat tggcttctct
1321 gccttccctt ttgagctatt gcacacgcct gaaaagtggg tgaggttcaa gtacccaaag
1381 ctcatctcct attcctacat ggttcgtggg ggccactttg cggcctttga ggagccggag
1441 ctgctcgccc aggacatccg caagttcctg tcggtgctgg agcggcaatg acccacccct
1501 ctccccccgc ctgccacctc cccccacaag tgccctccag gcttttcttg gggaagatac
1561 cccttttctg aggaatgagt ttgcctccgt cccctgccca tgctgggagc ccacgctcac
1621 cccctcaccc ctccaagctc actccccaac ccccaactcc gtgtggtaag caacatggct
1681 ttgatgataa acgactttac tcta
//