LOCUS HUMINAE 3927 bp mRNA linear HUM 12-MAR-1999
DEFINITION Homo sapiens integrin alpha E precursor, mRNA, complete cds.
ACCESSION L25851
VERSION L25851.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3927)
AUTHORS Shaw,S.K., Cepek,K.L., Murphy,E.A., Russell,G.J., Brenner,M.B. and
Parker,C.M.
TITLE Molecular cloning of the human mucosal lymphocyte integrin alpha E
subunit. Unusual structure and restricted RNA distribution
JOURNAL J. Biol. Chem. 269 (8), 6016-6025 (1994)
PUBMED 8119947
REFERENCE 2 (bases 1 to 3927)
AUTHORS Parker,C.M.
TITLE Direct Submission
JOURNAL Submitted (02-MAR-1994) Brigham and Women's Hospital, Division of
Rheumatology, Immunology and Allergy, Smith Building, Room 552B, 1
Jimmy Fund Way, Boston, MA 02115, USA
REFERENCE 3 (bases 1 to 3927)
AUTHORS Parker,C.M.
TITLE Direct Submission
JOURNAL Submitted (11-MAR-1999) Brigham and Women's Hospital, Division of
Rheumatology, Immunology and Allergy, Smith Building, Room 552B, 1
Jimmy Fund Way, Boston, MA 02115, USA
REMARK Sequence update by submitter
COMMENT On Mar 12, 1999 this sequence version replaced L25851.1.
FEATURES Location/Qualifiers
source 1..3927
/db_xref="H-InvDB:HIT000192645"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="032891"
/cell_type="TGF-beta1 induced cultured intra-epithelial
lymphocytes"
/tissue_type="intestine"
/dev_stage="adult"
CDS 126..3665
/codon_start=1
/product="integrin alpha E precursor"
/protein_id="AAB59359.2"
/translation="MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQ
DPSTNQTWLLVTSPRTKRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHH
GVLICIQVLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCY
SNKEGGGEDDVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDF
QRAKDFISNMMRNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVG
SVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGV
ERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEGT
VGDALHYQLAQIGFSAQILDERQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAAA
ADAEAAQYSYLGYAVAVLHKTCSLSYVAGAPQYKHHGAVFELQKEGREASFLPVLEGE
QMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHGEEGRVYVYRLSEQDGSFSLARIL
SGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYNGHWDG
LSASPSQRIRASTVAPGLQYFGMSMAGGFDISGDGLADITVGTLGQAVVFRSRPVVRL
KVSMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRL
QCSDVRSCLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQT
DHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELTLNI
NLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVL
KRSSAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFRHGFVAVLSKP
SIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVAAVKKLTRTQAS
TVCTWSQERACAYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKDVTELQ
ILGEISFNKSLYEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLIVILVIL
FKCGFFKRKYQQLNLESIRKAQLKSENLLEEEN"
sig_peptide 126..179
mat_peptide 180..3662
/product="integrin alpha E"
/function="adhesion molecule"
/experiment="experimental evidence, no additional details
recorded"
misc_difference 1205
/replace="a"
misc_difference 2191..2192
/note="deletion"
/replace="c"
misc_difference 3247
/replace="c"
polyA_site 3861..3866
BASE COUNT 936 a 1061 c 1073 g 857 t
ORIGIN
1 gaattccggc ccccgtgtct gggcgtccgc ctcctggcct cctggctgag gggaagctga
61 gtgggccacg gcccatgtgt cgcactcgcc tcggctccca cacagccgcc tctgctccag
121 caaggatgtg gctcttccac actctgctct gcatagccag cctggccctg ctggccgctt
181 tcaatgtgga tgtggcccgg ccctggctca cgcccaaggg aggtgcccct ttcgtgctca
241 gctcccttct gcaccaagac cccagcacca accagacctg gctcctggtc accagcccca
301 gaaccaagag gacaccaggg cccctccatc gatgttccct tgtccaggat gaaatccttt
361 gccatcctgt agagcatgtc cccatcccca aggggaggca ccggggagtg accgttgtcc
421 ggagccacca cggtgttttg atatgcattc aagtgctggt ccggcggcct cacagcctca
481 gctcagaact cacaggcacc tgtagcctcc tgggccctga cctccgtccc caggctcagg
541 ccaacttctt cgaccttgaa aatctcctgg atccagatgc acgtgtggac actggagact
601 gctacagcaa caaagaaggc ggtggagaag acgatgtgaa cacagccagg cagcgccggg
661 ctctggagaa ggaggaggag gaagacaagg aggaggagga agacgaggag gaggaggaag
721 ctggcaccga gattgccatc atcctggatg gctcaggaag cattgatccc ccagactttc
781 agagagccaa agacttcatc tccaacatga tgaggaactt ctatgaaaag tgttttgagt
841 gcaactttgc cttggtgcag tatggaggag tgatccagac tgagtttgac cttcgggaca
901 gccaggatgt gatggcctcc ctcgccagag tccagaacat cactcaagtg gggagtgtca
961 ccaagactgc ctcagccatg caacacgtct tagacagcat cttcacctca agccacggct
1021 ccaggagaaa ggcatccaag gtcatggtgg tgctcaccga tggtggcata ttcgaggacc
1081 ccctcaacct tacgacagtc atcaactccc ccaaaatgca gggtgttgag cgctttgcca
1141 ttggggtggg agaagaattt aagagtgcta ggactgcgag ggaactgaac ctgatcgcct
1201 cagacccgga tgagacccat gctttcaagg tgaccaacta catggcgctg gatgggctgc
1261 tgagcaaact gcggtacaac atcatcagca tggaaggcac ggttggagac gcccttcact
1321 accagctggc acagattggc ttcagtgctc agatcctgga tgagcggcag gtgctgctcg
1381 gcgccgtcgg ggcctttgac tggtccggag gggcgttgct ctacgacaca cgcagccgcc
1441 ggggccgctt cctgaaccag acagcggcgg cggcggcaga cgcggaggct gcgcagtaca
1501 gctacctggg ttacgctgtg gccgtgctgc acaagacctg cagcctctcc tacgtcgcgg
1561 gggctccaca gtacaaacat catggggccg tgtttgagct ccagaaggag ggcagagagg
1621 ccagcttcct gccagtgctg gagggagagc agatggggtc ctattttggc tctgagctgt
1681 gccctgtgga cattgacatg gatggaagca cggacttctt gctggtggct gctccatttt
1741 accacgttca tggagaagaa ggcagagtct acgtgtaccg tctcagcgag caggatggtt
1801 ctttctcctt ggcacgcata ctgagtgggc accccgggtt caccaatgcc cgctttggct
1861 ttgccatggc ggctatgggg gatctcagtc aggataagct cacagatgtg gccatcgggg
1921 cccccctgga aggttttggg gcagatgatg gtgccagctt cggcagtgtg tatatctaca
1981 atggacactg ggacggcctc tccgccagcc cctcgcagcg gatcagagcc tccacggtgg
2041 ccccaggact ccagtacttc ggcatgtcca tggctggtgg ctttgatatt agtggcgacg
2101 gccttgccga catcaccgtg ggcactctgg gccaggcggt tgtgttccgc tcccggcctg
2161 tggttcgcct gaaggtctcc atggccttca cccccagcgc actgcccatc ggcttcaacg
2221 gcgtcgtgaa tgtccgttta tgttttgaaa tcagctctgt aaccacagcc tctgagtcag
2281 gcctccgtga ggcacttctc aacttcacgc tggatgtgga tgtggggaag cagaggagac
2341 ggctgcagtg ttcagacgta agaagctgtc tgggctgcct gagggagtgg agcagcggat
2401 cccagctttg tgaggacctc ctgctcatgc ccacagaggg agagctctgt gaggaggact
2461 gcttctccaa tgccagtgtc aaagtcagct accagctcca gacccctgag ggacagacgg
2521 accatcccca gcccatcctg gaccgctaca ctgagccctt tgccatcttc cagctgccct
2581 atgagaaggc ctgcaagaat aagctgtttt gtgtcgcaga attacagttg gccaccaccg
2641 tctctcagca ggagttggtg gtgggtctca caaaggagct gaccctgaac attaacctaa
2701 ctaactccgg ggaagattcc tacatgacaa gcatggcctt gaattacccc agaaacctgc
2761 agttgaagag gatgcaaaag cctccctctc caaacattca gtgtgatgac cctcagccgg
2821 ttgcttctgt cctgatcatg aactgcagga ttggtcaccc cgtcctcaag aggtcatctg
2881 ctcatgtttc agtcgtttgg cagctagagg agaatgcctt tccaaacagg acagcagaca
2941 tcactgtgac tgtcaccaat tccaatgaaa gacggtcttt ggccaacgag acccacaccc
3001 ttcaattcag gcatggcttc gttgcagttc tgtccaaacc atccataatg tacgtgaaca
3061 caggccaggg gctttctcac cacaaagaat tcctcttcca tgtacatggg gagaacctct
3121 ttggagcaga ataccagttg caaatttgcg tcccaaccaa attacgaggt ctccaggttg
3181 cagcagtgaa gaagctgacg aggactcagg cctccacggt gtgcacctgg agtcaggagc
3241 gcgcttgtgc gtacagttcg gttcagcatg tggaagaatg gcattcagtg agctgtgtca
3301 tcgcttcaga taaagaaaat gtcaccgtgg ctgcagagat ctcctgggat cactctgagg
3361 agttactaaa agatgtaact gaactgcaga tccttggtga aatatctttc aacaaatctc
3421 tatatgaggg actgaatgca gagaaccaca gaactaagat cactgtcgtc ttcctgaaag
3481 atgagaagta ccattctttg cctatcatca ttaaaggcag cgttggtgga cttctggtgt
3541 tgatcgtgat tctggtcatc ctgttcaagt gtggcttttt taaaagaaaa tatcaacaac
3601 tgaacttgga gagcatcagg aaggcccagc tgaaatcaga gaatctgctc gaagaagaga
3661 attaggacct gctatccact gggagaggct atcagccagt cctgggactt ggagacccag
3721 catcctttgc attacttttt ccttcaggat gatctagagc agcatggagc tgttggtaga
3781 atattagttt ttaaccatac attgtcccaa aagtgtctgt gcattgtgca aaaagtaaac
3841 ttaggaaaca tttggtatta aataaattta cacttttctt tgcaaaaaaa aaaaaaaaaa
3901 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//