LOCUS HUMPWD 5413 bp mRNA linear HUM 12-OCT-1995
DEFINITION Homo sapiens (PWD) gene mRNA, 3' end.
ACCESSION L25591
VERSION L25591.1
KEYWORDS P-type ATPase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5413)
AUTHORS Tanzi,R.E., Petrukhin,K., Chernov,I., Pellequer,J.L., Wasco,W.,
Ross,B., Romano,D.M., Parano,E., Pavone,L., Brzustowicz,L.M.,
Devoto,M., Peppercorn,J., Bush,A.I., Sternlieb,I., Pirastu,M.,
Gusella,J.F., Evgrafov,O., Penchaszadeh,G.K., Honig,B.,
Edelman,I.S., Soares,M.B., Scheinberg,I.H. and Gilliam,T.C.
TITLE The Wilson disease gene is a copper transporting ATPase with
homology to the Menkes disease gene
JOURNAL Nat. Genet. 5 (4), 344-350 (1993)
PUBMED 8298641
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5413
/db_xref="H-InvDB:HIT000192631"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 10..1047
/gene="PWD"
CDS 10..1047
/gene="PWD"
/function="transmembrane copper transporting P-type
ATPase"
/note="putative"
/codon_start=1
/protein_id="AAA79211.1"
/translation="MTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPE
DLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQG
SHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVAL
QRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMT
CASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVV
SESCSTNPLGNHSAGNSMVQTTDGTPTSCRKWLPTLGGSLQTMPRTSWQSPHNQPEQW
HRRSASYRSKA"
CDS 1044..3332
/note="ORF; label: ORF"
/codon_start=1
/protein_id="AAA79212.1"
/translation="MTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPL
EIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVA
LATSKALVKFDPEIIGPRDIIKIIESKTSEALAKLMSLQATEATVVTLGEDNLIIREE
QVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIARS
INAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKNPNKHISQTEVIIRFAFQTSITVL
CIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVP
RVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQ
AVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREW
LRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQS
MGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGV
NDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVL
ALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYE
AQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSA
AADDDGDKWSLLLNGRDEEQYI"
3'UTR 3331..5411
polyA_site 5413
BASE COUNT 1275 a 1382 c 1432 g 1324 t
ORIGIN
1 gtggagggca tgacctgcca gtcctgtgtc agctccattg aaggcaaggt ccggaaactg
61 caaggagtag tgagagtcaa agtctcactc agcaaccaag aggccgtcat cacttatcag
121 ccttatctca ttcagcccga agacctcagg gaccatgtaa atgacatggg atttgaagct
181 gccatcaaga gcaaagtggc tcccttaagc ctgggaccaa ttgatattga gcggttacaa
241 agcactaacc caaagagacc tttatcttct gctaaccaga attttaataa ttctgagacc
301 ttggggcacc aaggaagcca tgtggtcacc ctccaactga gaatagatgg aatgcattgt
361 aagtcttgcg tcttgaatat tgaagaaaat attggccagc tcctaggggt tcaaagtatt
421 caagtgtcct tggagaacaa aactgcccaa gtaaagtatg acccttcttg taccagccca
481 gtggctctgc agagggctat cgaggcactt ccacctggga attttaaagt ttctcttcct
541 gatggagccg aagggagtgg gacagatcac aggtcttcca gttctcattc ccctggctcc
601 ccaccgagaa accaggtcca gggcacatgc agtaccactc tgattgccat tgccggcatg
661 acctgtgcat cctgtgtcca ttccattgaa ggcatgatct cccaactgga aggggtgcag
721 caaatatcgg tgtctttggc cgaagggact gcaacagttc tttataatcc ctctgtaatt
781 agcccagaag aactcagagc tgctatagaa gacatgggat ttgaggcttc agtcgtttct
841 gaaagctgtt ctactaaccc tcttggaaac cacagtgctg ggaattccat ggtgcaaact
901 acagatggta cacctacatc ttgcaggaag tggctcccca cactgggagg ctccctgcaa
961 accatgcccc ggacatcttg gcaaagtccc cacaatcaac cagagcagtg gcaccgcaga
1021 agtgcttctt acagatcaaa ggcatgacct gtgcatcctg tgtgtctaac atagaaagga
1081 atctgcagaa agaagctggt gttctctccg tgttggttgc cttgatggca ggaaaggcag
1141 agatcaagta tgacccagag gtcatccagc ccctcgagat agctcagttc atccaggacc
1201 tgggttttga ggcagcagtc atggaggact acgcaggctc cgatggcaac attgagctga
1261 caatcacagg gatgacctgc gcgtcctgtg tccacaacat agagtccaaa ctcacgagga
1321 caaatggcat cacttatgcc tccgttgccc ttgccaccag caaagccctt gttaagtttg
1381 acccggaaat tatcggtcca cgggatatta tcaaaattat tgagagcaaa acctcagaag
1441 ccctggctaa actcatgtct ctccaagcca cagaagccac cgttgtgacc cttggtgagg
1501 acaatttaat catcagggag gagcaagtcc ccatggagct ggtgcagcgg ggcgatatcg
1561 tcaaggtggt ccctggggga aagtttccag tggatgggaa agtcctggaa ggcaatacca
1621 tggctgatga gtccctcatc acaggagaag ccatgccagt cactaagaaa cccggaagca
1681 ctgtaattgc gaggtctata aatgcacatg gctctgtgct cattaaagct acccacgtgg
1741 gcaatgacac cactttggct cagattgtga aactggtgga agaggctcag atgtcaaaga
1801 accccaacaa gcacatctcc cagacagagg tgatcatccg gtttgctttc cagacgtcca
1861 tcacggtgct gtgcattgcc tgcccctgct ccctggggct ggccacgccc acggctgtca
1921 tggtgggcac cggggtggcc gcgcagaacg gcatcctcat caagggaggc aagcccctgg
1981 agatggcgca caagataaag actgtgatgt ttgacaagac tggcaccatt acccatggcg
2041 tccccagggt catgcgggtg ctcctgctgg gggatgtggc cacactgccc ctcaggaagg
2101 ttctggctgt ggtggggact gcggaggcca gcagtgaaca ccccttgggc gtggcagtca
2161 ccaaatactg taaagaggaa cttggaacag agaccttggg atactgcacg gacttccagg
2221 cagtgccagg ctgtggaatt gggtgcaaag tcagcaacgt ggaaggcatc ctggcccaca
2281 gtgagcgccc tttgagtgca ccggccagtc acctgaatga ggctggcagc cttcccgcag
2341 aaaaagatgc agtcccccag accttctctg tgctgattgg aaaccgtgag tggctgaggc
2401 gcaacggttt aaccatttct agcgatgtca gcgacgctat gacagaccac gagatgaaag
2461 gacagacagc catcctggtg gctattgacg gtgtgctctg tgggatgatc gcaatcgcag
2521 acgctgtcaa gcaggaggct gccctggctg tgcacacgct gcagagcatg ggtgtggacg
2581 tggttctgat cacgggggac aaccggaaga cagccagagc tattgccacc caggttggca
2641 tcaacaaagt ctttgcagag gtgctgcctt cgcacaaggt ggccaaggtc caggagctcc
2701 agaataaagg gaagaaagtc gccatggtgg gggatggggt caatgactcc ccggccttgg
2761 cccaggcaga catgggtgtg gccattggca ccggcacgga tgtggccatc gaggcagccg
2821 acgtcgtcct tatcagaaat gatttgctgg atgtggtggc tagcattcac ctttccaaga
2881 ggactgtccg aaggatacgc atcaacctgg tcctggcact gatttataac ctggttggga
2941 tacccattgc agcaggtgtc ttcatgccca tcggcattgt gctgcagccc tggatgggct
3001 cagcggccat ggcagcctcc tctgtgtctg tggtgctctc atccctgcag ctcaagtgct
3061 ataagaagcc tgacctggag aggtatgagg cacaggcgca tggccacatg aagcccctga
3121 cggcatccca ggtcagtgtg cacataggca tggatgacag gtggcgggac tcccccaggg
3181 ccacaccatg ggaccaggtc agctatgtca gccaggtgtc gctgtcctcc ctgacgtccg
3241 acaagccatc tcggcacagc gctgcagcag acgatgatgg ggacaagtgg tctctgctcc
3301 tgaatggcag ggatgaggag cagtacatct gatgacttca ggcaggcggg ccggggcagg
3361 gacttgcctc cactcaccac aagctgagca ggacagccag cagcaggatg ggctgagcta
3421 gcctccagct ttggggactt ccgctccctg gatatgtcca gtcatcctgc cctgcagcac
3481 gcggccttgt ctgggtgcag ctgggcttgg cctggagagg acggccctgc ctgcctcttg
3541 gcctcacggg accgtcagca tgggctttgt cttggactct agtccttggc tggactgtag
3601 aaggtgagag gcgagtcacc ctcctcacag acctctgctt ggagtattta ggatgactgc
3661 tgtgaaatgg agaacagttt catcaggacc aaaaaacctc actgggcctt tccagagaac
3721 tgcagacctc actgtcaggg tctttctgat gacgcctgtc tgtgtgcatc atgtttctga
3781 gaccacagtt tacctcaggt gtgcctgttg ctttcttcct gcatagtctg ttcctttctt
3841 cgtacatagt ctgttccttt tctctcctgt gtgcttgtca gtggggaccc ctcgcaaccc
3901 tgcctgtcac ctgggagggt gggaccaatg tccttgtggt ctttgctgct gctctcaggc
3961 gcttctccaa tgctctggag tgtgcatttc agcttgaacc tgcttcctgg ctcacacatc
4021 cccagccagg gagcttgcca cactcttctt caagttgagg agagttcttt tttgcttaaa
4081 gcccccttct ccatggagtg ttggcttctc aatagagtgt tgttgctgac cagctggagt
4141 gagggcctca gagcctgacc tgagagtccg tactcggctt cctgtggggt gtaggttctc
4201 gcgattcagg acgtccttcc atatccctgc ccagcctgtg gtgcttgaaa cgtttgcccc
4261 atgggaaacg tatgtgtgca ggagcctccc tgcacggccc aaggggcttc gttttcagtc
4321 ttctgactgt cacctcgtgg ggttcagtag agaattcaat tactagcgcc tggccttgtg
4381 tggcttggag gaaatggtac tgcccaaata ggaggaaaac acagcctccc tgagcctgca
4441 ttctgcacgc tgcccagggg cttcagaaaa ggagtggcca cagcaccccg aagggagcat
4501 ctatttacct ggcagtggct ctcagagcag cagaacgggt tcagttttag actctgaagt
4561 tggttgtgat tgacagaacc ctttgggagc aaactagtag agttggatta aattctgggt
4621 gaaacccttt tctcccacac aaaatagttt tagtgatttt tttcattgtc cattacttgc
4681 caggggcagt tttagcagca cttttgatag attacgtcta atcctcccaa ccaaccagca
4741 gggtagctat tactgtccac attttacagg caaggaaaca ggctccaaga ggctgaggac
4801 tttgcccagg atgacatagc caatggacaa gcagtgtctg tcagctgtga aggcttcact
4861 cttattgtcc ttctaccttg aatagaagtt ttcctgataa gaataaacga ggaaaaggtc
4921 cttgcctcct ggaagaacaa atctaccagg tgatctattc attgtttcaa ctcagaatgc
4981 acttgattca ggaggtcatc tgaccttcac cttggatggt tagtttcact ttttacatat
5041 agtttttgca gggttttatt ttataaaatc caagcgcgct gttgattgtg ttttccttgt
5101 tttcagcccc ccgactccag cccgcagcac atttccgctg tccgtcagta attgtgtcct
5161 ctctttatgc ttgcttgggg aatgttgttt tctgactagg ctgatcatta tctaaagaat
5221 ctaattctgt tgatttttaa aacttttagg accataaacg ttgtgttcat atatggacat
5281 ggaaatattt atataatttt atagaaaata accttttaga tggtcaaagt gtaaggagtt
5341 tttttgtcag ataatcattt ctacttcaaa aacatttcat gcaatattag aataaagttc
5401 ctgtcattcc tct
//