LOCUS       HUMWND                  1053 bp    mRNA    linear   HUM 28-JAN-1994
DEFINITION  Human Wilson disease-associated protein (WND) mRNA, partial cds.
ACCESSION   L25442
VERSION     L25442.1
KEYWORDS    Wilson disease-assocated protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1053)
  AUTHORS   Yamaguchi,Y., Heiny,M.E. and Gitlin,J.D.
  TITLE     Isolation and characterization of a human liver cDNA as a candidate
            gene for Wilson disease
  JOURNAL   Biochem. Biophys. Res. Commun. 197 (1), 271-277 (1993)
   PUBMED   8250934
COMMENT     Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1053
                     /db_xref="H-InvDB:HIT000192627"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="13q14.2-q21"
                     /tissue_type="liver"
     gene            1..1053
                     /gene="WND"
     CDS             <1..>1053
                     /gene="WND"
                     /note="transmembrane helix located at positions 602-670;
                     725-799"
                     /codon_start=2
                     /product="Wilson disease-associated protein"
                     /protein_id="AAA16173.1"
                     /translation="GKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIK
                     YDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRT
                     NGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRTPNAHHLDHKMEI
                     KQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTF
                     VQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTF
                     FDTLPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVP
                     MELVQRGDIRQGGPWGR"
     misc_binding    20..88
                     /gene="WND"
                     /note="homologous to Menke's copper binding domains;
                     putative; label: cu1"
                     /bound_moiety="copper"
     misc_binding    248..316
                     /gene="WND"
                     /note="homologous to Menke's copper binding domains;
                     putative; label: cu2"
                     /bound_moiety="copper"
BASE COUNT          251 a          279 c          266 g          257 t
ORIGIN      
        1 cgggaagtgc ttcttacaga tcaaaggcat gacctgtgca tcctgtgtgt ctaacataga
       61 aaggaatctg cagaaagaag ctggtgttct ctccgtgttg gttgccttga tggcaggaaa
      121 ggcagagatc aagtatgacc cagaggtcat ccagcccctc gagatagctc agttcatcca
      181 ggacctgggt tttgaggcag cagtcatgga ggactacgca ggctccgatg gcaacattga
      241 gctgacaatc acagggatga cctgcgcgtc ctgtgtccac aacatagagt ccaaactcac
      301 gaggacaaat ggcatcactt atgcctccgt tgcccttgcc accagcaaag cccttgttaa
      361 gtttgacccg gaaattatcg gtccacggga tattatcaaa attattgagg aaattggctt
      421 tcatgcttcc ctggcccaga gaacccccaa cgctcatcac ttggaccaca agatggaaat
      481 aaagcagtgg aagaagtctt tcctgtgcag cctggtgttt ggcatccctg tcatggcctt
      541 aatgatctat atgctgatac ccagcaacga gccccaccag tccatggtcc tggaccacaa
      601 catcattcca ggactgtcca ttctaaatct catcttcttt atcttgtgta cctttgtcca
      661 gctcctcggt gggtggtact tctacgttca ggcctacaaa tctctgagac acaggtcagc
      721 caacatggac gtgctcatcg tcctggccac aagcattgct tatgtttatt ctctggtcat
      781 cctggtggtt gctgtggctg agaaggcgga gaggagccct gtgacattct tcgacacgct
      841 ccccatgctc tttgtgttca ttgccctggg ccggtggctg gaacacttgg caaagagcaa
      901 aacctcagaa gccctggcta aactcatgtc tctccaagcc acagaagcca ccgttgtgac
      961 ccttggtgag gacaatttaa tcatcaggga ggagcaagtc cccatggagc tggtgcagcg
     1021 gggcgatata cgtcagggtg gtccctgggg ccg
//