LOCUS HUMHME 1778 bp mRNA linear HUM 31-DEC-1994
DEFINITION Human metalloproteinase (HME) mRNA, complete cds.
ACCESSION L23808
VERSION L23808.1
KEYWORDS metalloproteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1778)
AUTHORS Shapiro,S.D., Kobayashi,D.K. and Ley,T.J.
TITLE Cloning and characterization of a unique elastolytic
metalloproteinase produced by human alveolar macrophages
JOURNAL J. Biol. Chem. 268 (32), 23824-23829 (1993)
PUBMED 8226919
COMMENT Original source text: Homo sapiens adult cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1778
/db_xref="H-InvDB:HIT000192569"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="macrophage"
/dev_stage="adult"
gene 1..1778
/gene="HME"
CDS 13..1425
/gene="HME"
/codon_start=1
/product="metalloproteinase"
/protein_id="AAA58658.1"
/translation="MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLE
INKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDLHHFRE
MPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADIL
VVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVH
EIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDN
SEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEA
AYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRT
YFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFE
YDFLLQRITKTLKSNSWFGC"
polyA_site 1778
/gene="HME"
BASE COUNT 548 a 357 c 337 g 536 t
ORIGIN
1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct
61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac
121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt
181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc
241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat
301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac
361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa
421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg
481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc
541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat
601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct
661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg
721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt
781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat
841 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat
901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc
961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat
1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc
1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt
1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta
1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa
1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa
1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa
1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa
1441 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca
1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga
1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga
1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg
1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac
1741 taaaattaag tatatatatt ttggctcaaa taaaattg
//