LOCUS HUMRFC 4952 bp mRNA linear HUM 26-JAN-1994
DEFINITION Human replication factor C large subunit mRNA, complete cds.
ACCESSION L23320
VERSION L23320.1
KEYWORDS replication factor C; replication factor C large subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4952)
AUTHORS Bunz,F., Kobayashi,R. and Stillman,B.
TITLE cDNAs encoding the large subunit of human replication factor C
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (23), 11014-11018 (1993)
PUBMED 8248204
REFERENCE 2 (bases 1 to 4952)
AUTHORS Stillman,B.
TITLE Direct Submission
JOURNAL Submitted (01-NOV-1993) Bruce Stillman, Cold Spring Harbor
Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4952
/db_xref="H-InvDB:HIT000192535"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
CDS 207..3653
/function="subunit of a DNA polymerase accessory protein,
primer-template, structure specific DNA binding protein
and subunit of a DNA activated ATPase"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="replication factor C large subunit"
/protein_id="AAA16121.1"
/translation="MDIRKFFGVIPSGKKLVSETVKKNEKTKSDEETLKAKKGIKEIK
VNSSRKEDDFKQKQPSKKKRIIYDSDSESEETLQVKNAKKPPEKLPVSSKPGKISRQD
PVTYISETDEEDDFMCKKAASKSKENGRSTNSHLGTSNMKKNEENTKTKNKPLSPIKL
TPTSVLDYFGTGSVQRSNKKMVASKRKELSQNTDESGLNDEAIAKQLQLDEDAELERQ
LHEDEEFARTLAMLDEEPKTKKARKDTEAGETFSSVQANLSKAEKHKYPHKVKTAQVS
DERKSYSPRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKKESSYKEIE
PVASKRKENAIKLKGETKTPKKTKSSPAKKESVSPEDSEKKRTNYQAYRSYLNREGPK
ALGSKEIPKGAENCLEGLIFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVM
GRDSGQSKSDKAAALGTKIIDEDGLLNLIRTMPGKKSKYEIAVETEMKKESKLERTPQ
KNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKKETDVFWKSLDFKEQVAEETSGD
SKARNLADDSSENKVENLLWVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSE
DKKHAAKFGKFSGKDDGSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRS
KSSLKAIVAESLNNTSIKGFYSNGAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGL
IKHTKIPIICMCNDRNHPKIRSLVHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPP
AMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKADSHRAKKDIKMGPFDVARKVF
AAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDMKKHLMLLSRAADS
ICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKHSSTGKH
DRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYL
MKEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTS
PSLDSEYNEELNEDDSQSDEKDQDAIETDAMIKKKTKSSKPSKPEKDKEPRKGKGKSS
KK"
BASE COUNT 1660 a 932 c 1118 g 1242 t
ORIGIN
1 tcagtctggt actctttttt gaatgttgtc aaaactagtt aattggaagt taacggtact
61 atttatacta aaagagtacc agactgtctt cgccttcttg cacttcgcgg gagaagttgt
121 tggcgcgaat ggatcctgag cctcgataac agattcctca accggcccac ccgccagcca
181 gccagcgcct tcatcctggg gctgcgatgg acattcggaa attctttgga gtaataccaa
241 gtggaaagaa acttgtaagt gaaacagtaa agaagaatga gaaaacaaag tctgatgaag
301 aaactttaaa agcaaagaaa ggaataaagg aaatcaaggt aaatagctcc cgtaaagagg
361 atgacttcaa acaaaagcaa ccaagcaaga aaaagaggat catctatgat tcagattcag
421 agtcagagga gacgttgcag gtaaaaaatg ccaaaaagcc accagaaaaa ctgccagtat
481 cttctaaacc tggtaaaatt tcacggcagg atcctgttac atacatttca gaaacagatg
541 aagaagatga ctttatgtgt aagaaggcgg cctctaaatc aaaagagaat ggaagatcta
601 caaatagtca tcttggaaca tcaaacatga aaaagaatga agaaaacact aagaccaaga
661 ataagccttt atcaccaata aaacttacac ccacatcagt acttgattat tttggaactg
721 gaagtgtcca aagatctaat aagaagatgg tggcaagcaa aagaaaagag ctttcacaaa
781 atacagatga gtctggatta aatgatgaag ccatcgccaa gcaattacag cttgatgaag
841 atgcggagct ggagaggcag ttgcatgaag atgaagagtt tgccagaaca ttagccatgt
901 tggatgaaga acccaagacc aaaaaggctc gaaaggacac agaagcggga gaaacgtttt
961 catctgtcca agccaattta agtaaagcag aaaaacataa atatcctcat aaagtaaaaa
1021 cagcacaagt ttcagatgaa agaaagagct acagtcctag gaagcaaagt aaatatgaaa
1081 gttcaaaaga atctcagcaa cattccaagt catcagctga caaaatagga gaagtctctt
1141 ctcccaaggc cagttctaag ctggcaatta tgaaaagaaa aaaagagagc tcttataaag
1201 aaatagagcc tgtggcctca aaaagaaaag aaaatgccat taaattgaaa ggagagacaa
1261 aaactcctaa gaaaaccaaa agttctccag ctaaaaaaga gtctgtaagt cctgaagatt
1321 ctgaaaagaa acgcactaat tatcaagctt atcgaagcta cttaaatcga gaaggtccca
1381 aggctctggg ctccaaagaa ataccaaagg gagctgaaaa ttgcttggaa ggccttatat
1441 ttgtaatcac aggcgtgctg gagtctattg aacgagatga ggccaagtct ctaattgaac
1501 gttatggggg aaaagtaaca ggaaatgtca gcaagaaaac aaattatctt gtcatgggtc
1561 gtgatagtgg acagtccaag agtgataagg ccgcagcctt ggggacaaaa attattgatg
1621 aagatggcct gttgaatctg attcggacta tgccaggcaa gaaatccaag tatgaaatag
1681 cagttgaaac tgagatgaag aaagagtcca aactggagag aacaccccaa aaaaatgtcc
1741 aaggaaaaag aaaaattagt ccatctaaaa aggaatcaga atctaaaaag agcaggccga
1801 cttccaaaag ggacagtttg gcaaagacaa taaaaaagga aacagatgtg ttttggaaaa
1861 gcctggattt caaggagcag gtggctgagg agacaagtgg tgacagcaag gctaggaatt
1921 tggctgatga cagcagtgaa aacaaagtgg aaaatttgct ctgggtggat aaatataagc
1981 caacctcgct caagaccata attggacagc aaggtgacca gagctgtgcc aacaaactcc
2041 tacgctggct ccgaaactgg caaaagagtt cttccgaaga taaaaaacac gcagcaaagt
2101 ttggtaaatt ttccggcaaa gatgatggct ctagttttaa agcagcgttg ctgtcaggcc
2161 ctcctggtgt tggcaaaacc accacagctt ccctggtgtg tcaggagttg ggatacagct
2221 acgtggaact gaatgcaagt gacacccgga gtaagagcag tttgaaagcg attgttgctg
2281 agtcactgaa caataccagc atcaaaggct tttattcaaa tggagcagcc tcttcagtaa
2341 gcacgaaaca tgctctcatc atggatgaag tagatggcat ggcaggcaat gaggataggg
2401 gaggaattca ggaattaatt ggcctgataa aacatactaa aattcccatt atttgtatgt
2461 gcaatgatag aaatcatccc aagattcgct ctctggttca ttattgtttt gatcttcgtt
2521 ttcaaagacc tcgggttgaa cagattaagg gtgctatgat gtctattgca tttaaagaag
2581 gtttaaagat tccccctcca gctatgaatg aaataatttt gggagccaat caagatatca
2641 gacaggtttt acataatctg agtatgtggt gtgcacgaag taaagcatta acctatgacc
2701 aggccaaagc tgattctcac agagccaaaa aggatatcaa aatgggccca tttgatgttg
2761 cccggaaagt gtttgcagct ggagaggaga ctgctcacat gtcacttgtg gacaagtcag
2821 atctcttttt tcatgattat tcaatagcac ccctcttcgt ccaggaaaat tacatacacg
2881 tgaagcctgt agcagcaggg ggtgacatga aaaagcacct gatgctttta agcagagcag
2941 cagacagcat atgcgatggt gacctagtgg acagccagat ccggagtaag caaaactgga
3001 gtcttctgcc tgcgcaggcc atttatgcca gtgttcttcc tggagagttg atgagggggt
3061 acatgaccca gtttcccacc ttcccaagct ggctggggaa gcactcgtct acaggcaaac
3121 atgatcgtat tgttcaggac ctggccttgc atatgagtct cagaacttac tccagcaaaa
3181 ggactgtaaa catggattat ctgtcgcttc taagggatgc acttgtacag cccttgacct
3241 cacaaggagt agacggagta caggatgttg ttgcacttat ggacacatat tatttgatga
3301 aagaagactt tgagaatatc atggaaatca gcagctgggg tggcaaacct agtccctttt
3361 caaagctgga tcccaaggtg aaagcagcct tcacaagagc ttacaataag gaagcccacc
3421 ttactccata ctcacttcaa gctataaagg catctagaca cagcacaagc ccatccctgg
3481 attcggaata caatgaagaa ttaaatgaag atgactctca atctgatgag aaagaccaag
3541 atgctataga aactgatgcc atgatcaaga aaaagacaaa atcttcaaag ccttcaaaac
3601 cagaaaaaga taaggagccc agaaaaggaa aaggaaaaag ttcgaagaaa tgaaaccatt
3661 tttcactagc gacagccact ttttactctc cctcctgacc agtccagctg gtctagagaa
3721 agccttgttt tttcccagag caaccatgtt ttagcataat gggatgacct ggtgtcccat
3781 tataaataaa gggtggtatg gctagaaggg tatgagcagt aggcttatgt acacctctta
3841 tagaggttga taggactgct tgggtcctcc actgtcctct gtcaatctag ttagacgtgc
3901 ttctgaatga ctgtagaatt ggaactagaa actacacctg ggctttggag tcagatttta
3961 gttaacaata atgagcctgg agcagtagta ctaaggcgtc ttttgtaggc ttaagaattt
4021 atcctaatgg cctttatagg accaatgctg atttttttta aaggcagttc ctattatgtg
4081 gtgaaatttt gtaaataaat gattatacaa aacagtcacc acctagaact gggtattctt
4141 tgtacattgt cagatatctt tcaaagtata aattaggaat aaaaatgttc cacatgatat
4201 gtgtacaaat tctttttaag attgtcatct tgtacagcaa aatattatgt tggtatatta
4261 cttccttatt aatttgcaaa tgattggatt aaaaaagctc actgtattcc ttactaacct
4321 gttgtgtgaa acataacatt ggcagtcgag gagtcagaac tcggattccc agcctcactc
4381 cctctgtgtg tgttgaccac gtctctgctg tgaataggat ttcatgcagt ggtctgttat
4441 ggggctttgc agcgtggggg gctgcagaag attctcagac attcttatcc ttctggagtc
4501 tcaacccatc aggttcagac cagtaggaac caggctgggt caggctctta atttcactac
4561 ggtgggggac aaaatgaaca ctggcttttg ttcactttgc ccctgagaga tctagtcctg
4621 tcctgtgatg gcttccacaa accctgttgg aagtttgggt tattcctata actgtatgtg
4681 ttgagtggcc gtgacgtatg gacctagcct ggaatttaga tgtctagcta ttttttaatc
4741 ttgttggtaa atgctcagag gtctgtgcta cctctgtgag gtatatacta aaatgaatgt
4801 aaaataagga tcgtattccc tgctttaagg aactggtagt cttgtttggg tgatgagaca
4861 aagttcttga gacatttaaa ctgtatttac cagtgtgaaa aatgtcattt atggagatta
4921 attcattatg gaaataaaac attgcctaag ca
//