LOCUS HUMMLLAF4F 6940 bp mRNA linear HUM 15-SEP-1993
DEFINITION Human MLL-AF4 der(11) fusion protein mRNA, complete cds.
ACCESSION L22179
VERSION L22179.1
KEYWORDS MLL-AF4 fusion protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6940)
AUTHORS Domer,P.H., Fakharzadeh,S.S., Chen,C.S., Jockel,J., Johansen,L.,
Silverman,G.A., Kersey,J.H. and Korsmeyer,S.J.
TITLE Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4
fusion product
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (16), 7884-7888 (1993)
PUBMED 7689231
COMMENT Original source text: Homo sapiens adult cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..6940
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="der(11)t(4;11)(q21;q23)"
/cell_line="RS4;11"
/cell_type="leukemia"
/dev_stage="adult"
CDS 5..6940
/codon_start=1
/product="MLL-AF4 der(11) fusion protein"
/protein_id="AAC37520.1"
/translation="MAHSCRWRFPARPGTTGGGGGGGRRGLGGGPRQRVPALLLPPGP
PVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSG
PALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGELTTQIPCSWRTKGHIH
DKKTEPFRLLAWSWCLNDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDR
NSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISE
LPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVR
RRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVR
IIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAI
SSRIIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSD
SSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSV
SERSFGSRTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIP
FGLCSNNPLTSPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEG
LIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRA
PRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRT
RSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQR
PRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKS
RERDREREKENKRESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKAT
GRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTL
CLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTD
QPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKIL
FSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQV
PEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSK
TSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAP
GPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPES
GPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNIFSTLSNGNSSKQKIPA
DGVHRIRVDFKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQ
HVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPP
SAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPT
TNKWQLDNWLTKVSSQLRHQRAPGAQSPHGGTQRVRAAATVPRVRSILNPKILPLKAP
AKPPRPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGERE
PGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALS
GPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSSSRTSGCRQAVVVQEDSRKDRLPLP
LRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQ
SSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQR
RVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREEKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSL
KSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQA
PSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVT
ITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQE
LTKTP"
BASE COUNT 2041 a 1905 c 1631 g 1363 t
ORIGIN
1 taacatggcg cacagctgtc ggtggcgctt ccccgcccga cccgggacca ccgggggcgg
61 cggcggcggg gggcgccggg gcctaggggg cggcccgcgg caacgcgtcc cggccctgct
121 gcttcccccc gggcccccgg tcggcggtgg cggccccggg gcgcccccct cccccccggc
181 tgtggcggcc gcggcggcgg cggcgggaag cagcggggct ggggttccag ggggagcggc
241 cgccgcctca gcagcctcct cgtcgtccgc ctcgtcttcg tcttcgtcat cgtcctcagc
301 ctcttcaggg ccggccctgc tccgggtggg cccgggcttc gacgcggcgc tgcaggtctc
361 ggccgccatc ggcaccaacc tgcgccggtt ccgggccgtg tttggggaga gcggcggggg
421 aggcggcagc ggagagctaa caacacagat cccatgtagt tggagaacca aaggccacat
481 acatgacaaa aagactgaac cgttcaggtt acttgcatgg agttggtgct taaatgatga
541 gcaattctta ggttttggct cagatgaaga agtcagagtg cgaagtccca caaggtctcc
601 ttcagttaaa actagtcctc gaaaacctcg tgggagacct agaagtggct ctgaccgaaa
661 ttcagctatc ctctcagatc catctgtgtt ttcccctcta aataaatcag agaccaaatc
721 tggagataag atcaagaaga aagattctaa aagtatagaa aagaagagag gaagacctcc
781 caccttccct ggagtaaaaa tcaaaataac acatggaaag gacatttcag agttaccaaa
841 gggaaacaaa gaagatagcc tgaaaaaaat taaaaggaca ccttctgcta cgtttcagca
901 agccacaaag attaaaaaat taagagcagg taaactctct cctctcaagt ctaagtttaa
961 gacagggaag cttcaaatag gaaggaaggg ggtacaaatt gtacgacgga gaggaaggcc
1021 tccatcaaca gaaaggataa agaccccttc gggtctcctc attaattctg aactggaaaa
1081 gccccagaaa gtccggaaag acaaggaagg aacacctcca cttacaaaag aagataagac
1141 agttgtcaga caaagccctc gaaggattaa gccagttagg attattcctt cttcaaaaag
1201 gacagatgca accattgcta agcaactctt acagagggca aaaaaggggg ctcaaaagaa
1261 aattgaaaaa gaagcagctc agctgcaggg aagaaaggtg aagacacagg tcaaaaatat
1321 tcgacagttc atcatgcctg ttgtcagtgc tatctcctcg cggatcatta agacccctcg
1381 gcggtttata gaggatgagg attatgaccc tccaattaaa attgcccgat tagagtctac
1441 accgaatagt agattcagtg ccccgtcctg tggatcttct gaaaaatcaa gtgcagcttc
1501 tcagcactcc tctcaaatgt cttcagactc ctctcgatct agtagcccca gtgttgatac
1561 ctccacagac tctcaggctt ctgaggagat tcaggtactt cctgaggagc ggagcgatac
1621 ccctgaagtt catcctccac tgcccatttc ccagtcccca gaaaatgaga gtaatgatag
1681 gagaagcaga aggtattcag tgtcggagag aagttttgga tctagaacga cgaaaaaatt
1741 atcaactcta caaagtgccc cccagcagca gacctcctcg tctccacctc cacctctgct
1801 gactccaccg ccaccactgc agccagcctc cagtatctct gaccacacac cttggcttat
1861 gcctccaaca atcccctttg gcttatgctc caacaatccc cttacttcac cctttttgcc
1921 tgcttccact gctcctatgc aagggaagcg aaaatctatt ttgcgagaac cgacatttag
1981 gtggacttct ttaaagcatt ctaggtcaga gccacaatac ttttcctcag caaagtatgc
2041 caaagaaggt cttattcgca aaccaatatt tgataatttc cgaccccctc cactaactcc
2101 cgaggacgtt ggctttgcat ctggtttttc tgcatctggt accgctgctt cagcccgatt
2161 gttttcgcca ctccattctg gaacaaggtt tgatatgcac aaaaggagcc ctcttctgag
2221 agctccaaga tttactccaa gtgaggctca ctctagaata tttgagtctg taaccttgcc
2281 tagtaatcga acttctgctg gaacatcttc ttcaggagta tccaatagaa aaaggaaaag
2341 aaaagtgttt agtcctattc gatctgaacc aagatctcct tctcactcca tgaggacaag
2401 aagtggaagg cttagtagtt ctgagctctc acctctcacc cccccgtctt ctgtctcttc
2461 ctcgttaagc atttctgtta gtcctcttgc cactagtgcc ttaaacccaa cttttacttt
2521 tccttctcat tccctgactc agtctgggga atctgcagag aaaaatcaga gaccaaggaa
2581 gcagactagt gctccggcag agccattttc atcaagtagt cctactcctc tcttcccttg
2641 gtttacccca ggctctcaga ctgaaagagg gagaaataaa gacaaggccc ccgaggagct
2701 gtccaaagat cgagatgctg acaagagcgt ggagaaggac aagagtagag agagagaccg
2761 ggagagagaa aaggagaata agcgggagtc aaggaaagag aaaaggaaaa agggatcaga
2821 aattcagagt agttctgctt tgtatcctgt gggtagggtt tccaaagaga aggttgttgg
2881 tgaagatgtt gccacttcat cttctgccaa aaaagcaaca gggcggaaga agtcttcatc
2941 acatgattct gggactgata ttacttctgt gactcttggg gatacaacag ctgtcaaaac
3001 caaaatactt ataaagaaag ggagaggaaa tctggaaaaa accaacttgg acctcggccc
3061 aactgcccca tccctggaga aggagaaaac cctctgcctt tccactcctt catctagcac
3121 tgttaaacat tccacttcct ccataggctc catgttggct caggcagaca agcttccaat
3181 gactgacaag agggttgcca gcctcctaaa aaaggccaaa gctcagctct gcaagattga
3241 gaagagtaag agtcttaaac aaaccgacca gcccaaagca cagggtcaag aaagtgactc
3301 atcagagacc tctgtgcgag gaccccggat taaacatgtc tgcagaagag cagctgttgc
3361 ccttggccga aaacgagctg tgtttcctga tgacatgccc accctgagtg ccttaccatg
3421 ggaagaacga gaaaagattt tgttttccat ggggaatgat gacaagtcat caattgctgg
3481 ctcagaagat gctgaacctc ttgctccacc catcaaacca attaaacctg tcactagaaa
3541 caaggctccc caggaacctc cagtaaagaa aggacgtcga tcgaggcggt gtgggcagtg
3601 tcccggctgc caggtgcctg aggactgtgg tgtttgtact aattgcttag ataagcccaa
3661 gtttggtggt cgcaatataa agaagcagtg ctgcaagatg agaaaatgtc agaatctaca
3721 atggatgcct tccaaagcct acctgcagaa gcaagctaaa gctgtgaaaa agaaagagaa
3781 aaagtctaag accagtgaaa agaaagacag caaagagagc agtgttgtga agaacgtggt
3841 ggactctagt cagaaaccta ccccatcagc aagagaggat cctgccccaa agaaaagcag
3901 tagtgagcct cctccacgaa agcccgtcga ggaaaagagt gaagaaggga atgtctcggc
3961 ccctgggcct gaatccaaac aggccaccac tccagcttcc aggaagtcaa gcaagcaggt
4021 ctcccagcca gcactggtca tcccgcctca gccacctact acaggaccgc caagaaaaga
4081 agttcccaaa accactccta gtgagcccaa gaaaaagcag cctccaccac cagaatcagg
4141 tccagagcag agcaaacaga aaaaagtggc tccccgccca agtatccctg taaaacaaaa
4201 accaaaagaa aaggaaaaac cacctccggt caataagcag gagaatgcag gcactttgaa
4261 catcttcagc actctctcca atggcaatag ttctaagcaa aaaattccag cagatggagt
4321 ccacaggatc agagtggact ttaagcagac ctactccaat gaagtccatt gtgttgaaga
4381 gattctgaag gaaatgaccc attcatggcc gcctcctttg acagcaatac atacgcctag
4441 tacagctgag ccatccaagt ttcctttccc tacaaaggac tctcagcatg tcagttctgt
4501 aacccaaaac caaaaacaat atgatacatc ttcaaaaact cactcaaatt ctcagcaagg
4561 aacgtcatcc atgctcgaag acgaccttca gctcagtgac agtgaggaca gtgacagtga
4621 acaaacccca gagaagcctc cctcctcatc tgcacctcca agtgctccac agtcccttcc
4681 agaaccagtg gcatcagcac attccagcag tgcagagtca gaaagcacca gtgactcaga
4741 cagttcctca gactcagaga gcgagagcag ttcaagtgac agcgaagaaa atgagcccct
4801 agaaacccca gctccggagc ctgagcctcc aacaacaaac aaatggcagc tggacaactg
4861 gctgaccaaa gtcagcagcc agctgcgcca ccagagggcc ccaggagcac agagccccca
4921 cggcggcacc cagagagtaa gggcagcagc gacagtgcca cgagtcagga gcattctgaa
4981 tccaaagatc ctccccctaa aagctccagc aaagcccccg cgcccacccg aagcccccca
5041 ccccggaaag aggagctgtc agaagtctcc ggcacagcag gagcccccac aaaggcaaac
5101 cgttggaacc aaacaaccca aaaaacctgt caaggcctct gcccgggcag gttcacggac
5161 cagcctgcag ggggaaaggg agccagggct tcttccctat ggctcccgag accagacttc
5221 caaagacaag cccaaggtga agacgaaagg acggccccgg gccgcagcaa gcaacgaacc
5281 caagccagca gtgcccccct ccagtgagaa gaagaagcac aagagctccc tccctgcccc
5341 ctctaaggct ctctcaggcc cagaacccgc gaaggacaat gtggaggaca ggacccctga
5401 gcactttgct cttgttcccc tgactgagag ccagggccca ccccacagtg gcagcagcag
5461 caggactagt ggctgccgcc aagccgtggt ggtccaggag gacagccgca aagacagact
5521 cccattgcct ttgagagaca ccaagctgct ctcaccgctc agggacactc ctcccccaca
5581 aagcttgatg gtgaagatca ccctagacct gctctctcgg ataccccagc ctcccgggaa
5641 ggggagccgc cagaggaaag cagaagataa acagccgccc gcagggaaga agcacagctc
5701 tgagaagagg agctcagaca gctcaagcaa gttggccaaa aagagaaagg gtgaagcaga
5761 aagagactgt gataacaaga aaatcagact ggagaaggaa atcaaatcac agtcatcttc
5821 atcttcatcc tcccacaaag aatcttctaa aacaaagccc tccaggccct cctcacagtc
5881 ctcaaagaag gaaatgctcc ccccgccacc cgtgtcctcg tcctcccaga agccagccaa
5941 gcctgcactt aagaggtcaa ggcgggaagc agacacctgt ggccaggacc ctcccaaaag
6001 tgccagcagt accaagagca accacaaaga ctcttccatt cccaagcaga gaagagtaga
6061 ggggaagggc tccagaagct cctcggagca caagggttct tccggagata ctgcaaatcc
6121 ttttccagtg ccttctttgc caaatggtaa ctctaaacca gggaagcctc aagtgaagtt
6181 tgacaaacaa caagcagacc ttcacatgag ggaggaaaaa aagatgaagc agaaagcaga
6241 gttaatgacg gacagggttg gaaaggcttt taagtacctg gaagccgtct tgtccttcat
6301 tgagtgcgga attgccacag agtctgaaag ccagtcatcc aagtcagctt actctgtcta
6361 ctcagaaact gtagatctca ttaaattcat aatgtcatta aaatccttct cagatgccac
6421 agcgccaaca caagagaaaa tatttgctgt tttatgcatg cgttgccagt ccattttgaa
6481 catggcgatg tttcgttgta aaaaagacat agcaataaag tattctcgta ctcttaataa
6541 acacttcgag agttcttcca aagtcgccca ggcaccttct ccatgcattg caagaagcac
6601 aggcacacca tcccctcttt ccccaatgcc ttctcctgcc agctccgtag ggtcccagtc
6661 aagtgctggc agtgtgggga gcagtggggt ggctgccact atcagcaccc cagtcaccat
6721 ccagaatatg acatcttcct atgtcaccat cacatcccat gttcttaccg cctttgacct
6781 ttgggaacag gccgaggccc tcacgaggaa gaataaagaa ttctttgctc ggctcagcac
6841 aaatgtgtgc accttggccc tcaacagcag tttggtggac ctggtgcact atacacgaca
6901 gggttttcag cagctacaag aattaaccaa aacaccttaa
//