LOCUS HUMNTCP 1580 bp mRNA linear HUM 29-JUN-1994
DEFINITION Human Na/taurocholate cotransporting polypeptide mRNA, complete
cds.
ACCESSION L21893
VERSION L21893.1
KEYWORDS Na/taurocholate cotransporting polypeptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1580)
AUTHORS Hagenbuch,B. and Meier,P.J.
TITLE Molecular cloning, chromosomal localization, and functional
characterization of a human liver Na+/bile acid cotransporter
JOURNAL J. Clin. Invest. 93 (3), 1326-1331 (1994)
PUBMED 8132774
COMMENT Original source text: Homo sapiens adult liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1580
/db_xref="H-InvDB:HIT000192481"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="14"
/cell_type="hepatocyte"
/tissue_type="liver"
/dev_stage="adult"
CDS 83..1132
/function="mediates transport of bile acids"
/standard_name="NTCP"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="Na/taurocholate cotransporting polypeptide"
/protein_id="AAA36381.1"
/translation="MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGC
TMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGG
NLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIV
ISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAM
TPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPP
EVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGAL
GNGTYKGEDCSPCTA"
polyA_site 1580
/note="putative"
BASE COUNT 400 a 434 c 341 g 405 t
ORIGIN
1 aaagaaggca tccagcaaga actgcacaag aaacggagtc agccggagaa caaggagtgg
61 tcttccactg cctcacagga ggatggaggc ccacaacgcg tctgccccat tcaacttcac
121 cctgccaccc aactttggca agcgccccac agacctggca ctgagcgtca tcctggtgtt
181 catgttgttc ttcatcatgc tctcgctggg ctgcaccatg gagttcagca agatcaaggc
241 tcacttatgg aagcctaaag ggctggccat cgccctggtg gcacagtatg gcatcatgcc
301 cctcacggcc tttgtgctgg gcaaggtctt ccggctgaag aacattgagg cactggccat
361 cttggtctgt ggctgctcac ctggagggaa cctgtccaat gtcttcagtc tggccatgaa
421 gggggacatg aacctcagca ttgtgatgac cacctgctcc accttctgtg cccttggcat
481 gatgcctctc ctcctgtaca tctactccag ggggatctat gatggggacc tgaaggacaa
541 ggtgccctat aaaggcatcg tgatatcact ggtcctggtt ctcattcctt gcaccatagg
601 gatcgtcctc aaatccaaac ggccacaata catgcgctat gtcatcaagg gagggatgat
661 catcattctc ttgtgcagtg tggccgtcac agttctctct gccatcaatg tggggaagag
721 catcatgttt gccatgacac cactcttgat tgccacctcc tccctgatgc cttttattgg
781 ctttctgctg ggttatgttc tctctgctct cttctgcctc aatggacggt gcagacgcac
841 tgtcagcatg gagactggat gccaaaatgt ccaactctgt tccaccatcc tcaatgtggc
901 ctttccacct gaagtcattg gaccactttt cttctttccc ctcctctaca tgattttcca
961 gcttggagaa gggcttctcc tcattgccat attttggtgc tatgagaaat tcaagactcc
1021 caaggataaa acaaaaatga tctacacagc tgccacaact gaagaaacaa ttccaggagc
1081 tctgggaaat ggcacctaca aaggggagga ctgctcccct tgcacagcct agcccttccc
1141 ctggtggcct ggattctggt cccaaagcaa ttctgaaagc cagtgtggta aactagagag
1201 agcagcaaaa acaccagtct tgcctgagtc tttctccagc atttccagta catctatcag
1261 aatcatcaag tcttggccgg gaacacagac agggtgtcta cccaagaagc ctcacctatc
1321 cccaacttag aatttgctac ttattttaaa gacttgttca gtgactgtaa actctatgaa
1381 accagaaacc gaatctgcct cttgctggga tctctaaaag tgtctgataa gcatcttaaa
1441 gtcactcaat tcctgaacta atcaatatat atgtttaacc cattactcaa atacccaaat
1501 cccattccaa gttttgtgac ccaaaagaga aataaatgct cacaagtgct gtagaattaa
1561 acttcagaag ttctaacctt
//