LOCUS HUMAUAP69X 1672 bp mRNA linear HUM 11-APR-1995
DEFINITION Human autoantigen p69 mRNA, complete cds.
ACCESSION L21181
VERSION L21181.1
KEYWORDS autoantigen p69; diabetes.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1672)
AUTHORS Miyazaki,I., Gaedigk,R., Hui,M.F., Cheung,R.K., Morkowski,J.,
Rajotte,R.V. and Dosch,H.M.
TITLE Cloning of human and rat p69 cDNA, a candidate autoimmune target in
type 1 diabetes
JOURNAL Biochim. Biophys. Acta 1227 (1-2), 101-104 (1994)
PUBMED 7918678
REFERENCE 2 (bases 1 to 1672)
AUTHORS Dosch,H.M.
TITLE Direct Submission
JOURNAL Submitted (31-DEC-1993) H.M. Dosch, Immunology and Cancer, The
Hospital for Sick Children, 555 University Avenue, Toronto,
Ontario, Canada, M5G 1X8
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1672
/db_xref="H-InvDB:HIT000192448"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="beta cell"
/tissue_type="pancreatic islets"
CDS 77..1528
/function="target antigen in autoimmune (Type I) Diabetes
Mellitus"
/note="putative"
/codon_start=1
/product="autoantigen p69"
/protein_id="AAA64927.1"
/translation="MSGHKCSYPWDLQDRYAQDKSVVNKMQQKYWETKQAFIKATGKK
EDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKGICFLSQEENELGKFLRSQG
FQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRME
QCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL
LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKK
LVEKEEKKKINQQESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGST
HTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSK
EWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAAS
DLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA"
BASE COUNT 526 a 368 c 389 g 389 t
ORIGIN
1 ataatataac ttatcctctc atgctttttt cctgcccctt ctccccaaat catcaacaat
61 agaagaagaa gaaaacatgt caggacacaa atgcagttat ccctgggact tacaggatcg
121 atatgctcaa gataagtcag ttgtaaataa gatgcaacag aaatattggg agacgaagca
181 ggcctttatt aaagccacag ggaagaagga agatgaacat gttgttgcct ctgacgcgga
241 cctggatgcc aagctagagc tgtttcattc aattcagaga acctgtctgg acttatcgaa
301 agcaattgta ctctatcaaa aggggatatg tttcttgtct caagaagaaa acgaactggg
361 aaaatttctt cgatcccaag gtttccaaga taaaaccaga gcaggaaaga tgatgcaagc
421 gacaggaaag gccctctgct tttcttccca gcaaaggttg gccttacgaa atcctttgtg
481 tcgatttcac caagaagtgg agacttttcg gcatcgggcc atctcagata cttggctgac
541 ggtgaaccgc atggaacagt gcaggacgga atatagagga gcactattat ggatgaagga
601 cgtgtctcag gagcttgatc cagacctcta caagcaaatg gagaagttca ggaaggtaca
661 aacacaagtg cgccttgcaa aaaaaaactt tgacaaattg aagatggatg tttgtcaaaa
721 agtggatctt cttggagcga gcagatgcaa tctcttgtct cacatgctag caacatacca
781 gaccactctg cttcattttt gggagaaaac ttctcacact atggcagcca tccatgagag
841 tttcaaaggt tatcaaccat atgaatttac tactttaaag agcttacaag accctatgaa
901 aaaattagtt gagaaagaag agaagaagaa aatcaaccag caggaaagta cagatgcagc
961 cgtgcaggag ccgagccaat taatttcatt agaggaagaa aaccagcgca aggaatcctc
1021 tagttttaag actgaagatg gaaaaagtat tttatctgcc ttagacaaag gctctacaca
1081 tactgcatgc tcaggaccca tagatgaact attagacatg aaatctgagg aaggtgcttg
1141 cctgggacca gtggcaggga ccccggaacc tgaaggtgct gacaaagatg acctgctgct
1201 gttgagtgag atcttcaatg cttcctcctt ggaagagggc gagttcagca aagagtgggc
1261 cgctgtgttt ggagacggcc aagtgaagga gccagtgccc actatggccc tgggagagcc
1321 agaccccaag gcccagacag gctcaggttt ccttccttcg cagcttttag accaaaatat
1381 gaaagactta caggcctcgc tacaagaacc tgctaaggct gcctcagacc tgactgcctg
1441 gttcagcctc ttcgctgacc tcgacccact ctcaaatcct gatgctgttg ggaaaaccga
1501 taaagaacac gaattgctca atgcatgaat ctgtaccctt cggagggcac tcacatgccg
1561 cccccagcag ctcccctggg ggctagcaga agtataaagt gatcagtatg ctgttttaat
1621 aattatgtgc cattttaata aaatgaaagg gtcaacggcc ctgttaaaaa aa
//