LOCUS HUMATP2B2X 4979 bp mRNA linear HUM 27-OCT-1994
DEFINITION Human plasma membrane calcium ATPase isoform 2 (ATP2B2) mRNA,
complete cds.
ACCESSION L20977
VERSION L20977.1
KEYWORDS calcium ATPase; isoform 2; plasma membrane.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4979)
AUTHORS Kuzmin,I., Stackhouse,T., Latif,F., Duh,F.M., Geil,L., Gnarra,J.,
Yao,M., Orcutt,M.L., Li,H., Tory,K., Le Paslier,D., Chumakov,I.,
Cohen,D., Chinault,A.C., Linehan,W.M., Lerman,M.I. and Zbar,B.
TITLE One-megabase yeast artificial chromosome and 400-kilobase
cosmid-phage contigs containing the von Hippel-Lindau tumor
suppressor and Ca(2+)-transporting adenosine triphosphatase isoform
2 genes
JOURNAL Cancer Res. 54 (9), 2486-2491 (1994)
PUBMED 8162598
REFERENCE 2 (bases 1 to 4979)
AUTHORS Latif,F., Duh,F.-M., Gnarra,J.R., Tory,K., Kuzmin,I., Yao,M.C.,
Stackhouse,T., Modi,W., Geil,L., Schmidt,L., Li,H., Orcutt,M.,
Maher,E., Richards,F.O. Jr., Ferguson-Smith,M.A., Le Paslier,D.,
Linehan,M., Zbar,B. and Lerman,M.I.
TITLE von Hippel-Lindau syndrome: cloning and identification of the
plasma membrane Ca(++)-transporting ATPase isoform 2 gene that
resides in the von Hippel-Lindau gene region
JOURNAL Cancer Res. 53 (4), 861-867 (1993)
PUBMED 8428366
FEATURES Location/Qualifiers
source 1..4979
/db_xref="H-InvDB:HIT000192447"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3p25-26"
/tissue_type="brain"
/dev_stage="adult"
/tissue_lib="lambda gt10"
gene 1..4979
/gene="ATP2B2"
5'UTR 1..576
/gene="ATP2B2"
CDS 577..4173
/gene="ATP2B2"
/EC_number="3.6.3.8"
/note="PMCA-2"
/codon_start=1
/product="plasma membrane calcium ATPase isoform 2"
/protein_id="AAA50877.1"
/translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEA
LQDVTLIILEIAAIISLGLSFYHRPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLS
VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY
GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAV
GVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMH
KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYV
QYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA
ICSDKTGTLTTNRMTVVQAYVDDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKIL
PPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMST
VIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGL
RTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITV
RMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKL
RVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTD
VAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQ
DSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHA
VYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIH
GERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGEL
VWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRG
LNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLE
EDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
3'UTR 4171..4978
/gene="ATP2B2"
regulatory 4863..4867
/regulatory_class="polyA_signal_sequence"
/gene="ATP2B2"
polyA_site 4979
/gene="ATP2B2"
BASE COUNT 1165 a 1462 c 1384 g 968 t
ORIGIN
1 gggcagccgc ggcagaggag ccgcagccgc agcggggccg ggccgggccg ggcgcgcacc
61 agcggcagcg gcagcggcag cggcggcggc agcatctcgc tctcggagcc ggcgcaggtt
121 tccctgtact tagagcgtgg actgtgaacc cccaagcaga cgagctgaac ttcgtcaccc
181 agtccctaga gccagcaaga catgggcccc agtttccaga ccctgacacc tctcatttaa
241 ccagaagacg tggaggggag ccaccacccc tgaccatgta gatgccagtt ccagggagca
301 gcatgggccc cactgaatgg agactcctgg gtctacagcc ctgagcccct ccggcccctg
361 gacctcgtcc cacaccggag gacacctctt ggagctcacc accactgtca ccagcccgcc
421 tcggccaccc ccaccccccg ggacccggag tcggccgcct ggtgccacag ctgaccagtg
481 agggtgtgct gaggacagcc acaagcagcc atcacccggc agcctcttgt ccagcgctga
541 cccttgggcc cagcccgagc aaggaccgca gcaaacatgg gtgacatgac caacagcgac
601 ttttactcca aaaaccaaag aaatgagtcg agccatgggg gcgagttcgg gtgcacaatg
661 gaggagctcc gctccctcat ggagctgcgg ggcactgagg ctgtggtcaa gatcaaggag
721 acttatgggg acaccgaagc catctgccgg cgcctcaaaa cctcacctgt tgaaggtttg
781 ccgggcaccg ctccagacct ggaaaagaga aagcaaattt ttgggcaaaa ctttatacct
841 ccaaagaagc caaaaacctt cctgcagctc gtgtgggagg cgctgcagga cgtgacgctc
901 atcatcctgg agattgccgc catcatctcc ctggggctgt ccttctacca ccgccccggc
961 gagggcaacg aaggatgtgc gacggcccag ggtggggcag aggatgaagg agaggcagag
1021 gcaggttgga tcgagggggc cgccattctc ctctcagtta tctgtgtggt cctggtcacg
1081 gccttcaatg actggagcaa agagaaacag ttccggggcc tgcagagccg catcgagcag
1141 gaacagaaat ttaccgtggt ccgggctggc caggtggtcc agatccctgt ggctgagatc
1201 gtggttgggg acatagccca ggtcaaatat ggtgacctcc tccctgccga cggactcttc
1261 atccagggca atgacctcaa gattgatgaa agctccctaa ctggagagtc tgaccaggtg
1321 cgcaagtccg tggacaagga ccccatgctg ctgtcaggaa cccacgtgat ggagggctca
1381 ggacggatgt tggtgactgc tgtgggtgtg aactctcaga ctggcatcat ctttaccctc
1441 ctgggggctg gtggtgaaga ggaagagaag aaagacaaaa aagccaaaca gcaggacggg
1501 gcagccgcca tggagatgca gcccctcaag agtgccgagg gcggcgacgc tgacgacagg
1561 aagaaggcca gcatgcacaa gaaggagaag tccgtgctgc agggcaagct caccaagctg
1621 gctgtgcaga tcgggaaggc gggcttggtg atgtcagcca tcacggtgat catcctggtg
1681 ctctacttca ctgtggacac cttcgtggtc aacaagaagc cgtggctgcc tgagtgcacg
1741 cccgtctacg tgcagtactt tgtcaagttc ttcatcattg gcgtgacggt gctggtggtc
1801 gccgtgcccg aggggctccc tctggccgtc accatctcgt tggcctattc ggtgaagaaa
1861 atgatgaagg acaacaacct ggtacgccac ctggatgcct gtgagaccat gggcaatgcc
1921 acagccatct gctcagacaa gacaggcacg ctgaccacca atcgcatgac agtggtacag
1981 gcctatgtcg acgacgtcca ctataaagag atccccgacc ccagctccat caacaccaag
2041 actatggagc tgctgatcaa tgccatcgcc atcaacagcg cctacaccac caagattctg
2101 cccccagaga aggagggcgc cctgcctcgg caggtgggca acaagacgga gtgcggcctg
2161 ctgggcttcg tgctggacct gaagcaggac tacgagcccg tgcgcagcca gatgccagag
2221 gagaagttgt acaaagtgta caccttcaac tccgtgcgca agtccatgag cactgtcatc
2281 aagctgcccg acgagagctt ccgcatgtac agcaaggggg cttctgagat cgtgctcaag
2341 aagtgctgca aaatcctcaa tggggcggga gagcctcgtg tcttccggcc ccgcgaccgg
2401 gacgagatgg taaagaaggt gattgagccc atggcttgcg atgggctccg cactatctgc
2461 gtggcctacc gcgacttccc cagcagcccg gagccggact gggacaatga gaatgacatc
2521 ctcaacgaac tcacctgcat ctgcgtggtg ggcatcgagg acccggtgcg gccagaggtc
2581 ccagaagcca tccgcaagtg ccagcgggca ggcatcacgg tccgcatggt cactggcgac
2641 aatatcaaca cggctcgggc catcgccatc aagtgtggca tcatccatcc tggggaggac
2701 tttctgtgcc tcgagggcaa ggagttcaac aggaggatcc gcaacgagaa gggggagatt
2761 gagcaggagc gaattgacaa gatctggcca aagctgcggg tgctggctcg ctcctcccca
2821 acggacaagc ataccctggt taaaggcatc atcgacagca cacacactga gcagcggcag
2881 gtggtggccg tgacggggga cgggaccaac gacgggcctg cactcaagaa ggccgacgtg
2941 ggcttcgcca tgggcatcgc aggcactgac gtggccaagg aggcctcaga catcatcctg
3001 acagacgaca atttcagcag catcgtcaag gcagtgatgt ggggccgcaa cgtctatgac
3061 agcatctcca aattcttgca gttccagctc accgtcaacg tggtggccgt gattgtggcc
3121 ttcacaggcg cctgcatcac gcaggactcc cctctgaagg ccgtgcagat gctctgggtg
3181 aacctcatca tggacacgtt tgcctcgctg gcactggcca ctgagccgcc cacggagacc
3241 ctgctgctga ggaagccgta cggccgcaac aagccgctca tctccaggac catgatgaag
3301 aacatcctgg gccatgctgt ctaccagctt gccctcatct tcaccctgct ctttgttggc
3361 gagaagatgt tccagatcga cagcgggagg aacgcgcccc tgcattcgcc accctcagaa
3421 cattacacca tcatcttcaa caccttcgtc atgatgcagc tcttcaacga gatcaacgcc
3481 cgcaagatcc acggcgagcg caatgtcttt gacggcatct tccggaaccc catcttctgc
3541 accatcgtgc tgggcacctt tgccatccag atagtgatcg tgcagtttgg agggaagcca
3601 ttcagctgct ctccactgca gctggaccag tggatgtggt gcatattcat tgggttagga
3661 gagctcgttt ggggccaggt catcgccacc atcccgacca gcagactcaa gttcctcaag
3721 gaggcaggca ggctcacaca gaaggaggag atcccggagg aggagctcaa cgaggacgtg
3781 gaggagatcg accacgcaga gcgggagctg cggcggggcc agatcctgtg gttccgaggc
3841 ctgaatcgga tccagacaca gatccgcgtc gtgaaggcgt tccgtagctc tctctatgaa
3901 ggtttagaaa agcctgaatc tcgaacctcc atccataact tcatggctca tcctgaattc
3961 cggatcgaag attcccagcc ccacatcccc ctcattgatg acaccgacct ggaagaagat
4021 gccgcgctca agcagaactc gagcccgccg tcatccctca acaagaacaa cagcgccatc
4081 gacagtggga tcaacctgac gaccgacaca agcaaatcag ctacctcttc aagtccaggg
4141 agccccatcc acagcctgga gacgtcgctt tagctgagga ccctgtcgcc tgcccgcccg
4201 ccctcatgga ccccgctgtc acccgctttc cgggcaccca tccatccagg cacccaactc
4261 acccaagcag caacgagcaa caatcggaaa ccaaatactg gagagaaaac caacgtttcc
4321 acccacagac cctttctctg gctgcgatgc tgtttgaact ctttttcact tcaaggcaag
4381 gggcgggatc tccactgggg gcttacggga gtgagcggtt ttcccaaaac aagcccttcc
4441 tggctcccac ccagacatgg accagccatg cacccgccca gtcaccacgt cccccgcatg
4501 aatgtactgt acactttcaa tcctcccctt gtttggtttt tgggggttgg ggaggggttt
4561 ttgtttgttt gtttgttttc ttaggcggga actgcaaaca gactcttttc tgagactatt
4621 tatccaatcc actggtctgt gagtttttga aacgcttgca cagcatggtc tcagttgtat
4681 agattaattt aataactttt tgaaattgca gagcttaact cgcctagtag atttgcacca
4741 atggaaccga agaacttcat agacactcac aaggttatat ccatttcttt gtatctatat
4801 caacgtatac ttttccgaga ctgtatacgt ccatatagat aggtagatat atatatatat
4861 atataaatat atatacatgg atatataaag tttctttgcc ggcatgttgc cttgtttccg
4921 cttaaattgc tctattttaa cttatttatg tcctaaaaga agaatgtaat ttgtttaca
//