LOCUS HUMPDEG 4068 bp mRNA linear HUM 09-DEC-1993
DEFINITION Human phosphodiesterase mRNA, complete cds.
ACCESSION L20971
VERSION L20971.1
KEYWORDS phosphodiesterase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4068)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4068
/db_xref="H-InvDB:HIT000192446"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 766..2460
/note="putative"
/codon_start=1
/product="phosphodiesterase"
/protein_id="AAA03593.1"
/translation="MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQ
KLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEY
ISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT
ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFIT
YMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTL
RKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCAD
LSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQF
ELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT"
BASE COUNT 1145 a 913 c 878 g 1132 t
ORIGIN
1 gaattcctcc tctcttcacc ccgttagctg ttttcaatgt aatgctgccg tccttctctt
61 gcactgcctt ctgcgctaac acctccattc ctgtttataa ccgtgtattt attacttaat
121 gtatataatg taatgttttg taagttatta atttatatat ctaacattgc ctgccaatgg
181 tggtgttaaa tttgtgtaga aaactctgcc taagagttac gactttttct tgtaatgttt
241 tgtattgtgt attatataac ccaaacgtca cttagtagag acatatggcc cccttggcag
301 agaggacagg ggtgggcttt tgttcaaagg gtctgccctt tccctgcctg agttgctact
361 tctgcacaac ccctttatga accagttttc acccgaattt tgactgtttc atttagaaga
421 aaagcaaaat gagaaaaagc tttcctcatt tctccttgag atggcaaagc actcagaaat
481 gacatcacat accctaaaga accctgggat gactaaggca gagagagtct gagaaaactc
541 tttggtgctt ctgcctttag ttttaggaca catttatgca gatgagctta taagagaccg
601 ttccctccgc cttcttcctc agaggaagtt tcttggtaga tcaccgacac ctcatccagg
661 cggggggttg gggggaaact tggcaccagc catcccaggc agagcaccac tgtgatttgt
721 tctcctggtg gagagagctg gaaggaagga gccagcgtgc aaataatgaa ggagcacggg
781 ggcaccttca gtagcaccgg aatcagcggt ggtagcggtg actctgctat ggacagcctg
841 cagccgctcc agcctaacta catgcctgtg tgtttgtttg cagaagaatc ttatcaaaaa
901 ttagcaatgg aaacgctgga ggaattagac tggtgtttag accagctaga gaccatacag
961 acctaccggt ctgtcagtga gatggcttct aacaagttca aaagaatgct gaaccgggag
1021 ctgacacacc tctcagagat gagccgatca gggaaccagg tgtctgaata catttcaaat
1081 actttcttag acaagcagaa tgatgtggag atcccatctc ctacccagaa agacagggag
1141 aaaaagaaaa agcagcagct catgacccag ataagtggag tgaagaaatt aatgcatagt
1201 tcaagcctaa acaatacaag catctcacgc tttggagtca acactgaaaa tgaagatcac
1261 ctggccaagg agctggaaga cctgaacaaa tggggtctta acatctttaa tgtggctgga
1321 tattctcaca atagacccct aacatgcatc atgtatgcta tattccagga aagagacctc
1381 ctaaagacat tcagaatctc atctgacaca tttataacct acatgatgac tttagaagac
1441 cattaccatt ctgacgtggc atatcacaac agcctgcacg ctgctgatgt agcccagtcg
1501 acccatgttc tcctttctac accagcatta gacgctgtct tcacagattt ggagatcctg
1561 gctgccattt ttgcagctgc catccatgac gttgatcatc ctggagtctc caatcagttt
1621 ctcatcaaca caaattcaga acttgctttg atgtataatg atgaatctgt gttggaaaat
1681 catcaccttg ctgtgggttt caaactgctg caagaagaac actgtgacat cttcatgaat
1741 ctcaccaaga agcagcgtca gacactcagg aagatggtta ttgacatggt gttagcaact
1801 gatatgtcta aacatatgag cctgctggca gacctgaaga caatggtaga aacgaagaaa
1861 gttacaagtt caggcgttct tctcctagac aactataccg atcgcattca ggtccttcgc
1921 aacatggtac actgtgcaga cctgagcaac cccaccaagt ccttggaatt gtatcggcaa
1981 tggacagacc gcatcatgga ggaatttttc cagcagggag acaaagagcg ggagagggga
2041 atggaaatta gcccaatgtg tgataaacac acagcttctg tggaaaaatc ccaggttggt
2101 ttcatcgact acattgtcca tccattgtgg gagacatggg cagatttggt acagcctgat
2161 gctcaggaca ttctcgatac cttagaagat aacaggaact ggtatcagag catgatacct
2221 caaagtccct caccaccact ggacgagcag aacagggact gccagggtct gatggagaag
2281 tttcagtttg aactgactct cgatgaggaa gattctgaag gacctgagaa ggagggagag
2341 ggacacagct atttcagcag cacaaagacg ctttgtgtga ttgatccaga aaacagagat
2401 tccctgggag agactgacat agacattgca acagaagaca agtcccccgt ggatacataa
2461 tccccctctc cctgtggaga tgaacattct atccttgatg agcatgccag ctatgtggta
2521 gggccagccc accatggggg ccaagacctg cacaggacaa gggccacctg gcctttcagt
2581 tacttgagtt tggagtcaga aagcaagacc aggaagcaaa tagcagctca ggaaatccca
2641 cggttgactt gccttgatgg caagcttggt ggagagggct gaagctgttg ctgggggccg
2701 attctgatca agacacatgg cttgaaaatg gaagacacaa aactgagaga tcattctgca
2761 ctaagtttcg ggaacttatc cccgacagtg actgaactca ctgactaata acttcattta
2821 tgaatcttct cacttgtccc tttgtctgcc aacctgtgtg ccttttttgt aaaacatttt
2881 catgtcttta aaatgcctgt tgaatacctg gagtttagta tcaacttcta cacagataag
2941 ctttcaaagt tgacaaactt ttttgactct ttctggaaaa gggaaagaaa atagtcttcc
3001 ttctttcttg ggcaatatcc ttcactttac tacagttact tttgcaaaca gacagaaagg
3061 atacacttct aaccacattt tacttccttc ccctgttgtc cagtccaact ccacagtcac
3121 tcttaaaact tctctctgtt tgcctgcctc caacagtact tttaactttt tgctgtaaac
3181 agaataaaat tgaacaaatt agggggtaga aaggagcagt ggtgtcgttc accgtgagag
3241 tctgcataga actcagcagt gtgccctgct gtgtcttgga ccctgccccc cacaggagtt
3301 gctacagtcc ctggccctgc ttcccatcct cctctcttca ccccgttagc tgttttcaat
3361 gtaatgctgc cgtccttctc ttgcactgcc ttctgcgcta acacctccat tcctgtttat
3421 aaccgtgtat ttattactta atgtatataa tgtaatgttt tgtaagttat taatttatat
3481 atctaacatt gcctgccaat ggtggtgtta aatttgtgta gaaaactctg cctaagagtt
3541 acgacttttt cttgtaatgt tttgtattgt gtattatata acccaaacgt cacttagtag
3601 agacatatgg cccccttggc agagaggaca ggggtgggct tttgttcaaa gggtctgccc
3661 tttccctgcc tgagttgcta cttctgcaca acccctttat gaaccagttt tggaaacaat
3721 attctcacat tagatactaa atggtttata ctgagtcttt tacttttgta tagcttgata
3781 ggggcagggg caatgggatg tagtttttac ccaggttcta tccaaatcta tgtgggcatg
3841 agttgggtta taactggatc ctactatcat tgtggctttg gttcaaaagg aaacactaca
3901 tttgctcaca gatgattctt ctgattcttc tgaatgctcc cgaactactg actttgaaga
3961 ggtagcctcc tgcctgccat taagcaggaa tgtcatgttc cagttcatta caaaagaaaa
4021 caataaaaca atgtgaattt ttataataaa aaaaaaaaaa aggaattc
//