LOCUS HUMPDEE 3829 bp mRNA linear HUM 03-FEB-1998
DEFINITION Homo sapiens cyclic AMP phosphodiesterase mRNA, complete cds.
ACCESSION L20969
VERSION L20969.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3829)
AUTHORS Bolger,G., Michaeli,T., Martins,T., St John,T., Steiner,B.,
Rodgers,L., Riggs,M., Wigler,M. and Ferguson,K.
TITLE A family of human phosphodiesterases homologous to the dunce
learning and memory gene product of Drosophila melanogaster are
potential targets for antidepressant drugs
JOURNAL Mol. Cell. Biol. 13 (10), 6558-6571 (1993)
PUBMED 8413254
REFERENCE 2 (bases 1 to 3829)
AUTHORS Bolger,G.B., Erdogan,S., Jones,R.E., Loughney,K., Scotland,G.,
Hoffmann,R., Wilkinson,I., Farrell,C. and Houslay,M.D.
TITLE Characterization of five different proteins produced by
alternatively spliced mRNAs from the human cAMP-specific
phosphodiesterase PDE4D gene
JOURNAL Biochem. J. 328 (Pt 2), 539-548 (1997)
PUBMED 9371713
REFERENCE 3 (bases 1 to 3829)
AUTHORS Bolger,G.
TITLE Direct Submission
JOURNAL Submitted (23-JUL-1993) Medicine, University of Utah, 50 North
Medical Drive, Salt Lake City, UT 84132, USA
REFERENCE 4 (bases 1 to 3829)
AUTHORS Bolger,G.
TITLE Direct Submission
JOURNAL Submitted (18-NOV-1997) Medicine, University of Utah, 50 North
Medical Drive, Salt Lake City, UT 84132, USA
REMARK Sequence update by submitter
COMMENT On Nov 18, 1997 this sequence version replaced gi:347127.
FEATURES Location/Qualifiers
source 1..3829
/db_xref="H-InvDB:HIT000192444"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 423..2852
/codon_start=1
/product="cyclic AMP phosphodiesterase"
/protein_id="AAC00042.1"
/translation="MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLR
QPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATG
RVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTS
AGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHG
DDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKL
ASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFIS
NTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED
VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMT
LEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV
IDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNP
TKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPL
WETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTL
EEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPE
ACVIDDRSPDT"
BASE COUNT 1046 a 954 c 856 g 969 t
ORIGIN
1 gaattccctg gatacagcct ttttatgact tttacttcct ttatanncaa attccaacgt
61 cttctcattc ctccaccagg sctgtgccaa cctgggccca acccaaggsc ctcactaaac
121 catccaatca gtaggagcca tagactactt tatttagcca aagcaaaaat gagtcaactg
181 aattctgttt ttccatttac ttctgtctgt ttttccttcc tcttgccacc ctcagtgcca
241 caagagggga cccctctcgg tagccctgag gctctggcgc cttcaagtga gaagctaagc
301 accagcctct gctgggctgc agaagcggcg gcggcggcag cagcagcagc agcatcagga
361 aggctctcgg gccagcgcgg tgaacccggg ctgggcagca ggtcgcggag ccgcgagcca
421 ggatggaggc agagggcagc agcgcgccgg cccgggcggg cagcggagag ggcagcgaca
481 gcgccggcgg ggccacgctc aaagccccca agcatctctg gaggcacgag cagcaccacc
541 agtacccgct ccggcagccc cagttccgcc tcctgcatcc ccatcaccac ctgcccccgc
601 cgccgccacc ctcgccccag ccccagcccc agtgtccgct acagccgccg ccgccgcccc
661 ccctgccgcc gcccccgccg ccgcccgggg ctgcccgcgg ccgctacgcc tcgagcgggg
721 ccaccggccg cgtccggcat cgcggctact cggacaccga gcgctacctg tactgtcgcg
781 ccatggaccg cacctcctac gcggtggaga ccggccaccg gcccggcctg aagaaatcca
841 ggatgtcctg gccctcctcg ttccagggac tcaggcgttt tgatgtggac aatggcacat
901 ctgcgggacg gagtcccttg gatcccatga ccagcccagg atccgggcta attctccaag
961 caaattttgt ccacagtcaa cgacgggagt ccttcctgta tcgatccgac agcgattatg
1021 acctctctcc aaagtctatg tcccggaact cctccattgc cagtgatata cacggagatg
1081 acttgattgt gactccattt gctcaggtct tggccagtct gcgaactgta cgaaacaact
1141 ttgctgcatt aactaatttg caagatcgag cacctagcaa aagatcaccc atgtgcaacc
1201 aaccatccat caacaaagcc accataacag aggaggccta ccagaaactg gccagcgaga
1261 ccctggagga gctggactgg tgtctggacc agctagagac cctacagacc aggcactccg
1321 tcagtgagat ggcctccaac aagtttaaaa ggatgcttaa tcgggagctc acccatctct
1381 ctgaaatgag tcggtctgga aatcaagtgt cagagtttat atcaaacaca ttcttagata
1441 agcaacatga agtggaaatt ccttctccaa ctcagaagga aaaggagaaa aagaaaagac
1501 caatgtctca gatcagtgga gtcaagaaat tgatgcacag ctctagtctg actaattcaa
1561 gtatcccaag gtttggagtt aaaactgaac aagaagatgt ccttgccaag gaactagaag
1621 atgtgaacaa atggggtctt catgttttca gaatagcaga gttgtctggt aaccggccct
1681 tgactgttat catgcacacc atttttcagg aacgggattt attaaaaaca tttaaaattc
1741 cagtagatac tttaattaca tatcttatga ctctcgaaga ccattaccat gctgatgtgg
1801 cctatcacaa caatatccat gctgcagatg ttgtccagtc tactcatgtg ctattatcta
1861 cacctgcttt ggaggctgtg tttacagatt tggagattct tgcagcaatt tttgccagtg
1921 caatacatga tgtagatcat cctggtgtgt ccaatcaatt tctgatcaat acaaactctg
1981 aacttgcctt gatgtacaat gattcctcag tcttagagaa ccatcatttg gctgtgggct
2041 ttaaattgct tcaggaagaa aactgtgaca ttttccagaa tttgaccaaa aaacaaagac
2101 aatctttaag gaaaatggtc attgacatcg tacttgcaac agatatgtca aaacacatga
2161 atctactggc tgatttgaag actatggttg aaactaagaa agtgacaagc tctggagttc
2221 ttcttcttga taattattcc gataggattc aggttcttca gaatatggtg cactgtgcag
2281 atctgagcaa cccaacaaag cctctccagc tgtaccgcca gtggacggac cggataatgg
2341 aggagttctt ccgccaagga gaccgagaga gggaacgtgg catggagata agccccatgt
2401 gtgacaagca caatgcttcc gtggaaaaat cacaggtggg cttcatagac tatattgttc
2461 atcccctctg ggagacatgg gcagacctcg tccaccctga cgcccaggat attttggaca
2521 ctttggagga caatcgtgaa tggtaccaga gcacaatccc tcagagcccc tctcctgcac
2581 ctgatgaccc agaggagggc cggcagggtc aaactgagaa attccagttt gaactaactt
2641 tagaggaaga tggtgagtca gacacggaaa aggacagtgg cagtcaagtg gaagaagaca
2701 ctagctgcag tgactccaag actctttgta ctcaagactc agagtctact gaaattcccc
2761 ttgatgaaca ggttgaagag gaggcagtag gggaagaaga ggaaagccag cctgaagcct
2821 gtgtcataga tgatcgttct cctgacacgt aacagtgcaa aaactttcat gccttttttt
2881 tttttaagta gaaaaattgt ttccaaagtg catgtcacat gccacaacca cggtcacacc
2941 tcactgtcat ctgccaggac gtttgttgaa caaaactgac cttgactact cagtccagcg
3001 ctcaggaata tcgtaaccag ttttttcacc tccatgttca tccgagcaag gtggacatct
3061 tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc
3121 tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact
3181 tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga
3241 gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta
3301 ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga
3361 tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg
3421 taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta
3481 aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg
3541 caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt
3601 gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac
3661 caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt
3721 aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct
3781 tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatac
//