LOCUS HUMDAGI 5493 bp mRNA linear HUM 27-NOV-1995
DEFINITION Human dystroglycan (DAG1) mRNA, complete cds.
ACCESSION L19711
VERSION L19711.1
KEYWORDS dystroglycan.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5493)
AUTHORS Ibraghimov-Beskrovnaya,O., Milatovich,A., Ozcelik,T., Yang,B.,
Koepnick,K., Francke,U. and Campbell,K.P.
TITLE Human dystroglycan: skeletal muscle cDNA, genomic structure, origin
of tissue specific isoforms and chromosomal localization
JOURNAL Hum. Mol. Genet. 2 (10), 1651-1657 (1993)
PUBMED 8268918
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5493
/db_xref="H-InvDB:HIT000192365"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3p21"
/tissue_type="skeletal muscle"
/dev_stage="fetal and adult"
/tissue_lib="lambda-gt10 and gt11"
gene 1..5493
/gene="DAG1"
CDS 395..3082
/gene="DAG1"
/note="aa 751 to 764 is transmembrane domain"
/codon_start=1
/product="dystroglycan"
/protein_id="AAA81779.1"
/translation="MRMSVGLSLLLPLWGRTFLLLLSVVMAQSHWPSEPSEAVRDWEN
QLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKE
ALPSWLHWDSQSHTLEGLPLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVYPED
HSDLQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDLLHRMRSFS
EVELHNMKLVPVVNNRLFDMSAFMAGPGNPKKVVENGALLSWKLGCSLNQNSVPDIHG
VEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEP
PSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSE
AGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPT
KKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDA
WVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPD
SSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIH
KKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIA
EDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRD
PEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPI
IFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTMGEYTPLRDE
DPNAPPYQPPPPFTVPMEGKGSRPKNMTPYRSPPPYVPP"
sig_peptide 395..475
/gene="DAG1"
mat_peptide 476..3079
/gene="DAG1"
/product="dystroglycan"
polyA_site 5493
/gene="DAG1"
BASE COUNT 1199 a 1592 c 1437 g 1265 t
ORIGIN
1 gggccagtcg gcgccgcgcg gagctggccg ctggattggc tgcaacactc gcgtgtcagg
61 cggttgctag gctccggccg cgcgccccgc ccttgcgctc agcgccctct caccgcccgg
121 tacgtgctcg cgcgaaggct gcggcgcggc gctcgcgcct cttaggcttg gcggtggcgg
181 cggcggcagc ttcgcgccga atccccgggg agcggcggtg gcggcgtcct ggggccagga
241 ggagcgaaca cctgccgcgg tcctcccgcc ggcgctgggc tctgtgtgct ccgggatgga
301 gcaggtgtgc agagggtgag aacccagctc tgggaccaag tcacttgctt ccttacttag
361 caagactatc gacttgagca aacttggacc tgggatgagg atgtctgtgg gcctctcgct
421 gctgctgccc ctctggggga ggacctttct cctcctgctc tctgtggtta tggctcagtc
481 ccactggccc agtgaaccct cagaggctgt cagggactgg gaaaaccagc ttgaggcatc
541 catgcactca gtgctctcag acctccacga ggctgttccc acagtggttg gcattcctga
601 tggcacggct gtcgtcgggc gctcatttcg agtgaccatt ccaacagatt tgattgcctc
661 cagtggagat atcatcaagg tatcagcggc agggaaggag gctttgccat cttggctgca
721 ctgggactca cagagccaca ccctggaggg cctccccctt gacactgata agggtgtgca
781 ttacatttca gtgagcgcta cacggctggg ggccaacggg agccacatcc cccagacctc
841 cagtgtgttc tccatcgagg tctaccctga agaccacagt gatctgcagt cggtgaggac
901 agcctcccca gaccctggtg aggtggtatc atctgcctgt gctgcggatg aacctgtgac
961 tgttttgacg gtgattttgg atgccgacct caccaagatg accccaaagc aaaggattga
1021 cctcctgcac aggatgcgga gcttctcaga agtagagctt cacaacatga aattagtgcc
1081 ggtggtgaat aacagactat ttgacatgtc ggccttcatg gctggcccgg gaaatccaaa
1141 aaaggtggtg gagaatgggg cccttctctc ctggaagctg ggctgctccc tgaaccagaa
1201 cagtgtgcct gacattcatg gtgtagaggc ccctgccagg gagggcgcaa tgtctgctca
1261 gcttggctac cctgtggtgg gttggcacat cgccaataag aagccccctc ttcccaaacg
1321 cgtccggagg cagatccatg ctacacccac acctgtcact gccattgggc ccccaaccac
1381 ggctatccag gagcccccat ccaggatcgt gccaaccccc acatctccag ccattgctcc
1441 tccaacagag accatggctc ctccagtcag ggatcctgtt cctgggaaac ccacggtcac
1501 catccggact cgaggcgcca ttattcaaac cccaacccta ggccccatcc agcctactcg
1561 ggtgtcagaa gctggcacca cagttcctgg ccagattcgc ccaacgatga ccattcctgg
1621 ctatgtggag cctactgcag ttgctacccc tcccacaacc accaccaaga agccacgagt
1681 atccacacca aaaccagcaa cgccttcaac tgactccacc accaccacga ctcgcaggcc
1741 aaccaagaaa ccacggacac cccggccagt gccccgggtc accaccaaag tttccatcac
1801 cagattggaa actgcctcac cgcctactcg tattcgcacc accaccagtg gagtgccccg
1861 tggcggagaa cccaaccagc gcccagagct caagaaccat attgacaggg tagatgcctg
1921 ggttggcacc tactttgagg tgaagatccc gtcagacact ttctatgacc atgaggacac
1981 caccactgac aagctgaagc tgaccctgaa actgcgggag cagcagctgg tgggcgagaa
2041 gtcctgggta cagttcaaca gcaacagcca gctcatgtat ggccttcccg acagcagcca
2101 cgtgggcaaa cacgagtatt tcatgcatgc cacagacaag gggggcctgt cggctgtgga
2161 tgccttcgag atccacgtcc acaggcgccc ccaaggggat agggctcctg caaggttcaa
2221 ggccaagttt gtgggtgacc cggcactggt gttgaatgac atccacaaga agattgcctt
2281 ggtaaagaaa ctggccttcg cctttggaga ccgaaactgt agcaccatca ccctgcagaa
2341 tatcacccgg ggctccatcg tggtggaatg gaccaacaac acactgccct tggagccctg
2401 ccccaaggag cagatcgctg ggctgagccg ccggatcgct gaggatgatg gaaaacctcg
2461 gcctgccttc tccaacgccc tagagcctga ctttaaggcc acaagcatca ctgtgacggg
2521 ctctggcagt tgtcggcacc tacagtttat ccctgtggta ccacccagga gagtgccctc
2581 agaggcgccg cccacagaag tgcctgacag ggaccctgag aagagcagtg aggatgatgt
2641 ctacctgcac acagtcattc cggccgtggt ggtcgcagcc atcctgctca ttgctggcat
2701 cattgccatg atctgctacc gcaagaagcg gaagggcaag cttacccttg aggaccaggc
2761 caccttcatc aagaaggggg tgcctatcat ctttgcagac gaactggacg actccaagcc
2821 cccaccctcc tccagcatgc cactcattct gcaggaggag aaggctcccc taccccctcc
2881 tgagtacccc aaccagagtg tgcccgagac cactcctctg aaccaggaca ccatgggaga
2941 gtacacgccc ctgcgggatg aggatcccaa tgcgcctccc taccagcccc caccgccctt
3001 cacagtaccc atggagggca agggctcccg tcccaagaac atgaccccat accggtcacc
3061 tcctccctat gtcccacctt aacccgcaag cgcctgggtg gaggcagggt agggcagggc
3121 cctggagacg acatggtgtt gtctgtggag accggtggcc tgcagaccat tgcccaccgg
3181 gagccgacac ctgacctagc acacactgac acaggggcct ggacaagccc gccctctctg
3241 gtcctcccaa accccaaagc agctggagag actttgggga cttttttatt tttatttttt
3301 gcctaacagc ttttggtttg ttcatagaga actcttcgct tcatttttga tggctggctc
3361 tgaaagcacc atgtggagtg gaggtggagg gaccgaggaa ccatgaatga actcgcaggc
3421 agtgccgggc ggccccctgg ctctctgcgt tttgccttta acactaactg tactgttttt
3481 tctattcacg tgtgtctagc tgcaggatgt aacatggaaa acagtaacta aagattaaat
3541 tcaaaggact ttcagaagtt aaggttaagt ttttacgttt aatctgctgt ttacctaaac
3601 ttgtatgtat aatttttggg tgggtatggg gaattgcttt gctaaaaata agctcccagg
3661 gtgtttcaaa cttagagaag accaagggac agtatttttt atcaaaggaa tactattttt
3721 tcacactacg tcaacttggt tgctctgata ccccagagcc tgattggggg cctcccggcc
3781 ctggctcacg ccaagtccct ggtgctgggt ttgctctccc gctgttgcca ggggctggaa
3841 gctggagggg tctcttgggc catggacatc cccacttcca gcccatgtac actagtggcc
3901 cacgaccaag gggtcttcat ttccatgaaa aagggactcc aagaggcagt ggtggctgtg
3961 gcccccaact ttggtgctcc agggtgggcc aactgcttgt gggggcacct gggaggtcaa
4021 aggtctccac cacatcaacc tattttgttt tacccttttt ctgtgcattg tttttttttt
4081 tcctcctaaa aggaatatca cggttttttg aaacactcag tgggggacat tttggtgaag
4141 atgcaatatt tttatgtcat gtgatgctct ttcctcactt gaccttggcc gctttgtcct
4201 aacagtccac agtcctgccc cgacccaccc catccctttt ctctggcact ccagtccagc
4261 ttgggcctga actactggaa aaggtctggc ggctggggag gagtgccagc aatagttcat
4321 aataaaaatc tgttagctct caaagctaat tttttactaa agtttttata cagcctcaaa
4381 ttgttttatt aaaaaaaaga tttaaaatgg tgatgcttac agcagtttgt acgagctctt
4441 aagtgttgat tccatggaac tgacggcttt gcttgttttg attcttttcc ccctactttt
4501 cctaatggtt taaattctgg aattacactg gggttctttt gcctttttta gcagaacatc
4561 cgtccgtcca tctgcatctc tgtcccatga ctcaggggcg cccactctgc ttcgattctc
4621 ctcctgtgga agaaaccatt ttgagcatga cttttcttga tgtctgaagc gttattttgg
4681 gtacttttta gggaggaatg cctttcgcaa taatgtatcc attcccctga ttgagggtgg
4741 gtgggtggac ccaggctccc tttgcacaca gagcagctac ttctaagcca tatcgactgt
4801 tttgcagagg atttgtgtgt cctccctcag gaggggaggc ctggtaggag ggggggagag
4861 ttctctgtcc tactgctctc aagagggcat ttccccttgc gccttctccc acagggccca
4921 gcccctctcc cctgcccaag tccccagggg gtactctgga gtgagcagtc cccctgtggg
4981 ggagcctgta aatgcgggct cagtggacca ctggtgactg ggctcatgcc tccaagtcag
5041 agtttcccct ggtgccccag agacaggagc acaagtggga tctgacctgg tgagattatt
5101 tctgatgacc tcatcaaaaa ataaacaatt cccaatgttc caggtgaggg ctttgaaagg
5161 ccttccaaac agctccgtcg cccctagcaa ctccaccatt gggcactgcc atgcagagac
5221 gtggctggcc cagaatggcc tgttgccata gcaactggag gcgatggggc agtgaacaga
5281 ataacaacag caacaatgcc tttgcaggca gcctgctccc ctgagcgctg ggctggtgat
5341 ggccgttgga ctctgtgaga tggagagcca atctcacatt caagtgttca ccaaccactg
5401 atgtgttttt atttccttct atatgatttt aagatgtgtt ttctgcattc tgtaaagaaa
5461 catatcaaac taaataaaag cagtgtcttt att
//