LOCUS HUMMATK 1987 bp mRNA linear HUM 11-MAR-1994
DEFINITION Human tyrosine kinase (MATK) mRNA, complete cds.
ACCESSION L18974
VERSION L18974.1
KEYWORDS cytoplasmic protein; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1987)
AUTHORS Bennett,B.D., Cowley,S., Jiang,S., London,R., Deng,B., Grabarek,J.,
Groopman,J.E., Goeddel,D.V. and Avraham,H.
TITLE Identification and characterization of a novel tyrosine kinase from
megakaryocytes
JOURNAL J. Biol. Chem. 269 (2), 1068-1074 (1994)
PUBMED 8288563
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1987
/db_xref="H-InvDB:HIT000192318"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="CMK11-5"
/cell_type="megakaryocyte"
/dev_stage="adult"
/tissue_lib="lambda gt11"
gene 1..1987
/gene="MATK"
sig_peptide <1..63
/gene="MATK"
CDS 263..1846
/gene="MATK"
/codon_start=1
/product="tyrosine kinase"
/protein_id="AAA16703.1"
/translation="MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPT
RRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAA
GALRDGEALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCV
SFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKS
AEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDE
TAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL
HVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTA
PEALKHGFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPG
PVHVLMSSCWEAEPPAGHPSANWPRSWPGSYAVQVPQPPSQGRTPTVHLAPKPGALTP
PGGPWPQRTERVESAAWGH"
polyA_site 568
/gene="MATK"
BASE COUNT 369 a 628 c 672 g 318 t
ORIGIN
1 ggagcaactc gctccaagtt gtgcagccgg gaccgcctcg gggtgtgcag ccggctcgcg
61 gaggccctcc tgggggcggg cggggcgcgg ctcgggggcg ccccctgagc agaaaacagg
121 aagaaccagg ctcggtccag tggcacccag ctccctacct cctgtgccag ccgcctggcc
181 tgtggcaggc cattcccagc gtccccgact gtgaccactt gctcagtgtg cctctcacct
241 gcctcagttt cctctggggg cgatggcggg gcgaggctct ctggtttcct ggcgggcatt
301 tcacggctgt gattctgctg aggaacttcc ccgggtgagc ccccgcttcc tccgagcctg
361 gcacccccct cccgtctcag ccaggatgcc aacgaggcgc tgggccccgg gcacccagtg
421 tatcaccaaa tgcgagcaca cccgccccaa gccaggggag ctggccttcc gcaagggcga
481 cgtggtcacc atcctggagg cctgcgagaa caagagctgg taccgcgtca agcaccacac
541 cagtggacag gaggggctgc tggcagctgg ggcgctgcgg gacggggagg ccctctccgc
601 agaccccaag ctcagcctca tgccgtggtt ccacgggaag atctcgggcc aggaggctgt
661 ccagcagctg cagcctcccg aggatgggct gttcctggtg cgggagtccg cgcgccaccc
721 cggcgactac gtcctgtgcg tgagctttgg ccgcgacgtc atccactacc gcgtgctgca
781 ccgcgacggc cacctcacaa tcgatgaggc cgtgttcttc tgcaacctca tggacatggt
841 ggagcattac agcaaggaca agggcgctat ctgcaccaag ctggtgagac caaagcggaa
901 acacgggacc aagtcggccg aggaggagct ggccagggcg ggctggttac tgaacctgca
961 gcatttgaca ttgggagcac agatcggaga gggagagttt ggagctgtcc tgcagggtga
1021 gtacctgggg caaaaggtgg ccgtgaagaa tatcaagtgt gatgtgacag cccaggcctt
1081 cctggacgag acggccgtca tgacgaagat gcaacacgag aacctggtgc gtctcctggg
1141 cgtgatcctg caccaggggc tgtacattgt catggagcac gtgagcaagg gcaacctggt
1201 gaactttctg cggacccggg gtcgagccct cgtgaacacc gctcagctcc tgcagttttc
1261 tctgcacgtg gccgagggca tggagtacct ggagagcaag aagcttgtgc accgcgacct
1321 ggccgcccgc aacatcctgg tctcagagga cctggtggcc aaggtcagcg actttggcct
1381 ggccaaagcc gagcggaagg ggctagactc aagccggctg cccgtcaagt ggacggcgcc
1441 cgaggctctc aaacacgggt tcaccagcaa gtcggatgtc tggagttttg gggtgctgct
1501 ctgggaggtc ttctcatatg gacgggctcc gtaccctaaa atgtcactga aagaggtgtc
1561 ggaggccgtg gagaaggggt accgcatgga accccccgag ggctgtccag gccccgtgca
1621 cgtcctcatg agcagctgct gggaggcaga gccgcccgcc ggccaccctt ccgcaaactg
1681 gccgagaagc tggcccggga gctacgcagt gcaggtgccc cagcctccgt ctcagggcag
1741 gacgccgacg gtccacctcg ccccgaagcc aggagccctg accccacccg gtggcccttg
1801 gccccagagg accgagagag tggagagtgc ggcgtggggg cactgaccag gcccaaggag
1861 ggtccaggcg ggcaagtcat cctcctggtg cccacagcag gggctggccc acgtaggggg
1921 ctctgggcgg cccgtggaca ccccagacct gcgaaggatg atcgcccgat aaagacggat
1981 tctaagg
//