LOCUS HUMTGFBRS 1733 bp mRNA linear HUM 28-JAN-1994
DEFINITION Human TGF-b superfamily receptor type I mRNA, complete cds.
ACCESSION L17075
VERSION L17075.1
KEYWORDS heteromeric receptor; serine/threonine kinase; type I receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1733)
AUTHORS Attisano,L., Carcamo,J., Ventura,F., Weis,F.M., Massague,J. and
Wrana,J.L.
TITLE Identification of human activin and TGF beta type I receptors that
form heteromeric kinase complexes with type II receptors
JOURNAL Cell 75 (4), 671-680 (1993)
PUBMED 8242742
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1733
/db_xref="H-InvDB:HIT000192302"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HUVEC"
CDS 92..1603
/codon_start=1
/product="TGF-b superfamily receptor type I"
/protein_id="AAA16160.1"
/translation="MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGP
TCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLV
LEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGES
SLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWR
GLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLI
THYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSR
NVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFES
YKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPT
IPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ"
BASE COUNT 336 a 510 c 558 g 329 t
ORIGIN
1 tgatttcctc tgggcaggag ggagccacgg ccagcgcgtg tcacacttca tggctcttac
61 tccacctctc ttgctcctct ctgcagggac catgaccttg ggctccccca ggaaaggcct
121 tctgatgctg ctgatggcct tggtgaccca gggagaccct gtgaagccgt ctcggggccc
181 gctggtgacc tgcacgtgtg agagcccaca ttgcaagggg cctacctgcc ggggggcctg
241 gtgcacagta gtgctggtgc gggaggaggg gaggcacccc caggaacatc ggggctgcgg
301 gaacttgcac agggagctct gcagggggcg ccccaccgag ttcgtcaacc actactgctg
361 cgacagccac ctctgcaacc acaacgtgtc cctggtgctg gaggccaccc aacctccttc
421 ggagcagccg ggaacagatg gccagctggc cctgatcctg ggccccgtgc tggccttgct
481 ggccctggtg gccctgggtg tcctgggcct gtggcatgtc cgacggaggc aggagaagca
541 gcgtggcctg cacagcgagc tgggagagtc cagtctcatc ctgaaagcat ctgagcaggg
601 cgacagcatg ttgggggacc tcctggacag tgactgcacc acagggagtg gctcagggct
661 ccccttcctg gtgcagagga cagtggcacg gcaggttgcc ttggtggagt gtgtgggaaa
721 aggccgctat ggcgaagtgt ggcggggctt gtggcacggt gagagtgtgg ccgtcaagat
781 cttctcctcg agggatgaac agtcctggtt ccgggagact gagatctata acacagtgtt
841 gctcagacac gacaacatcc taggcttcat cgcctcagac atgacctccc gcaactcgag
901 cacgcagctg tggctcatca cgcactacca cgagcacggc tccctctacg actttctgca
961 gagacagacg ctggagcccc atctggctct gaggctagct gtgtccgcgg catgcggcct
1021 ggcgcacctg cacgtggaga tcttcggtac acagggcaaa ccagccattg cccaccgcga
1081 cttcaagagc cgcaatgtgc tggtcaagag caacctgcag tgttgcatcg ccgacctggg
1141 cctggctgtg atgcactcac agggcagcga ttacctggac atcggcaaca acccgagagt
1201 gggcaccaag cggtacatgg cacccgaggt gctggacgag cagatccgca cggactgctt
1261 tgagtcctac aagtggactg acatctgggc ctttggcctg gtgctgtggg agattgcccg
1321 ccggaccatc gtgaatggca tcgtggagga ctatagacca cccttctatg atgtggtgcc
1381 caatgacccc agctttgagg acatgaagaa ggtggtgtgt gtggatcagc agacccccac
1441 catccctaac cggctggctg cagacccggt cctctcaggc ctagctcaga tgatgcggga
1501 gtgctggtac ccaaacccct ctgcccgact caccgcgctg cggatcaaga agacactaca
1561 aaaaattagc aacagtccag agaagcctaa agtgattcaa tagcccagga gcacctgatt
1621 cctttctgcc tgcagggggc tgggggggtg gggggcagcg gatggtgcct atctgggtag
1681 aggtagtgtg agtgtgtgtg tgctgggatg gcagctgcgc ctgctgctcg ccc
//