LOCUS HUMCOMFACB 2388 bp mRNA linear HUM 16-MAR-1994
DEFINITION Human complement factor B mRNA, complete cds.
ACCESSION L15702
VERSION L15702.1
KEYWORDS complement factor; complement factor B.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2388)
AUTHORS Horiuchi,T., Kim,S., Matsumoto,M., Watanabe,I., Fujita,S. and
Volanakis,J.E.
TITLE Human complement factor B: cDNA cloning, nucleotide sequencing,
phenotypic conversion by site-directed mutagenesis and expression
JOURNAL Mol. Immunol. 30 (17), 1587-1592 (1993)
PUBMED 8247029
COMMENT Original source text: Homo sapiens (human).
FEATURES Location/Qualifiers
source 1..2388
/db_xref="H-InvDB:HIT000192282_05"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR 1..40
CDS 41..2335
/codon_start=1
/product="complement factor B"
/protein_id="AAA16820.1"
/translation="MGSNLSPQLCLMPFILGLLSGGVTTTPWSLAQPQGSCSLEGVEI
KGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIH
CPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDN
GAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSC
QDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLD
GSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADW
VTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLH
NMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQ
HVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGH
ESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKE
AGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLP
AQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLC
TGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARD
FHINLFQVLPWLKEKLQDEDLGFL"
sig_peptide 41..115
3'UTR 2336..2388
regulatory 2369..2374
/regulatory_class="polyA_signal_sequence"
BASE COUNT 630 a 601 c 649 g 508 t
ORIGIN
1 tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc
61 ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc
121 atggtctttg gcccagcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg
181 ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta
241 cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac
301 tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca
361 cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat
421 ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt
481 gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa
541 cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt
601 cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga
661 aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc
721 tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc
781 tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg
841 ctccatgaac atctacctgg tgctagatgg atcagacagc attggggcca gcaacttcac
901 aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc
961 aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc
1021 agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca
1081 caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag
1141 ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat
1201 gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga
1261 cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt
1321 gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga
1381 caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca
1441 aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg
1501 taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg
1561 acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg
1621 tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga
1681 cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc
1741 aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa
1801 atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt
1861 gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga
1921 tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat
1981 caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga
2041 caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag
2101 tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa
2161 gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa
2221 ccagaagcgg caaaagcagg tacctgctca cgcccgagac tttcacatca acctctttca
2281 agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tataaggggt
2341 ttcctgctgg acaggggcgt gggattgaat taaaacagct gcgacaac
//