LOCUS HUMPSFHOMO 1618 bp mRNA linear HUM 21-SEP-1993
DEFINITION Human mRNA, complete cds.
ACCESSION L14599
VERSION L14599.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1618)
AUTHORS Dong,B., Horowitz,D.S., Kobayashi,R. and Krainer,A.R.
TITLE Purification and cDNA cloning of HeLa cell p54nrb, a nuclear
protein with two RNA recognition motifs and extensive homology to
human splicing factor PSF and Drosophila NONA/BJ6
JOURNAL Nucleic Acids Res. 21 (17), 4085-4092 (1993)
PUBMED 8371983
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1618
/db_xref="H-InvDB:HIT000192252"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
5'UTR 1..136
misc_difference 71..127
/note="clone difference"
/replace=""
misc_difference 71..127
/note="clone difference"
/replace="aggcccagtatttaggcgacagtgaatttattactctgaagagggttc
tgcacatat
ttccaaattatattggtggtcatcagaataggtgataggaagaaatacttctcaag"
CDS 137..1552
/codon_start=1
/protein_id="AAC37578.1"
/translation="MQSNKTFNLEKQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPAN
GQQASSQNEGLTIDLKNFRKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGE
VFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRFACHSASLHVRNLPQYVS
NELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSEGSFLLTTF
PRPVTVEPMDQLDDEEGLPEKLVIKNQQFHKEREQPPRFAQPGSFEYEYAMRWKALIE
MEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEELRRMEELHNQEV
QKRKQLELRQEEERRRREEEMRRQQEEMMRRQQEGFKGTFPDAREQEIRMGQMAMGGA
MGINNRGAMPPAPVPAGTPAPPGPATMMPDGTLGLTPPTTERFGQAATMEGIGAIGGT
PPAFNRAAPGAEFAPNKRRRY"
misc_feature 296..1255
/note="DBHS;This region of the protein is highly
homologous to a human splicing factor PSF (GenBank
X70944), and to a Drosophila protein nonA/BJ6 (GenBank
M33496/X55902)."
misc_feature 359..577
/note="RNA recognition motif 1 (RRM1)"
misc_feature 581..820
/note="RNA recognition motif 2 (RRM2)"
3'UTR 1553..1618
BASE COUNT 469 a 380 c 451 g 318 t
ORIGIN
1 gctcttttct cgggacggga gaggccgtgt agcgtcgccg ttactccgag gagataccag
61 tcggtagagg agaagtcgag gttagaggga actgggaggc actttgctgt ctgcaatcga
121 agttgagggt gcaaaaatgc agagtaataa aacttttaac ttggagaagc aaaaccatac
181 tccaagaaag catcatcaac atcaccacca gcagcagcac caccagcagc aacagcagca
241 gccgccacca ccgccaatac ctgcaaatgg gcaacaggcc agcagccaaa atgaaggctt
301 gactattgac ctgaagaatt ttagaaaacc aggagagaag accttcaccc aacgaagccg
361 tctttttgtg ggaaatcttc ctcccgacat cactgaggaa gaaatgagga aactatttga
421 gaaatatgga aaggcaggcg aagtcttcat tcataaggat aaaggatttg gctttatccg
481 cttggaaacc cgaaccctag cggagattgc caaagtggag ctggacaata tgccactccg
541 tggaaagcag ctgcgtgtgc gctttgcctg ccatagtgca tcccttcacg ttcgaaacct
601 tcctcagtat gtgtccaacg aactgctgga agaagccttt tctgtgtttg gccaggtaga
661 gagggctgta gtcattgtgg atgatcgagg aaggccctca ggaaaaggca ttgttgagtt
721 ctcagggaag ccagctgctc ggaaagctct ggacagatgc agtgaaggct ccttcctgct
781 aaccacattt cctcgtcctg tcactgtgga gcccatggac cagttagatg atgaagaggg
841 acttccagag aagctggtta taaaaaacca gcaatttcac aaggaacgag agcagccacc
901 cagatttgca cagcctggct cctttgagta tgaatatgcc atgcgctgga aggcactcat
961 tgagatggag aagcagcagc aggaccaagt ggaccgcaac atcaaggagg ctcgtgagaa
1021 gctggagatg gagatggaag ctgcacgcca tgagcaccag gtcatgctaa tgagacagga
1081 tttgatgagg cgccaagaag aacttcggag gatggaagag ctgcacaacc aagaggtgca
1141 aaaacgaaag caactggagc tcaggcagga ggaagagcgc aggcgccgtg aagaagagat
1201 gcggcggcag caagaagaaa tgatgcggcg acagcaggaa ggattcaagg gaaccttccc
1261 tgatgcgaga gagcaggaga ttcggatggg tcagatggct atgggaggtg ctatgggcat
1321 aaacaacaga ggtgccatgc cccctgctcc tgtgccagct ggtaccccag ctcctccagg
1381 acctgccact atgatgccgg atggaacttt gggattgacc ccaccaacaa ctgaacgctt
1441 tggtcaggct gctacaatgg aaggaattgg ggcaattggt ggaactcctc ctgcattcaa
1501 ccgtgcagct cctggagctg aatttgcccc aaacaaacgt cgccgatact aataagttgc
1561 agtgtctagt ttctcaaaac ccttaaaaga aggacccttt ttggactagc cagaattc
//