LOCUS HUMGNEFB 3999 bp mRNA linear HUM 26-JUL-1993
DEFINITION Human guanine nucleotide exchange factor mRNA, complete cds.
ACCESSION L13858
VERSION L13858.1
KEYWORDS guanine nucleotide exchange factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3999)
AUTHORS Chardin,P., Camonis,J.H., Gale,N.W., van Aelst,L., Schlessinger,J.,
Wigler,M.H. and Bar-Sagi,D.
TITLE Human Sos1: a guanine nucleotide exchange factor for Ras that binds
to GRB2
JOURNAL Science 260 (5112), 1338-1343 (1993)
PUBMED 8493579
COMMENT Original source text: Homo sapiens (library: lambda gt10) fetus
brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3999
/db_xref="H-InvDB:HIT000192230"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
/dev_stage="fetus"
/tissue_lib="lambda gt10"
CDS 1..3999
/codon_start=1
/product="guanine nucleotide exchange factor"
/protein_id="AAA35914.1"
/translation="MQQAPQPYEFFSEENSPKWRGLLVSALRKVQVQVHPTLSANEES
LYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNP
LLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQ
DIKVSMCADKVLMDMFDQDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELN
MIIKVFREAFLSDRKLFKPSVYEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPL
AGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIADGFKEAVR
YVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNHQGSMDRIYKQY
SPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTR
IGAKHERHIFLFDGLMISCKPNHGQTRLPGYTSAEYRLKEKFVMRKIQICDKEDTCEH
KHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLR
LPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRT
FLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQP
VQLRVLNVFRHWVDHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQ
AQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLDPIEIARQLTLLESDLYRKVQ
PSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEI
LQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYL
VKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKRKGKDLINFSKRRKVAEITGEIQQY
QNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKST
FSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNT
PSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIP
PPLPPRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPP
PPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDISTCPNSPSTP
PSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLY
RLPLLENAETPQ"
BASE COUNT 1279 a 810 c 799 g 1111 t
ORIGIN
1 atgcagcagg cgccgcagcc ttacgagttc ttcagcgagg agaacagtcc gaaatggcgg
61 ggactgttgg tctcggccct gcggaaggtt caggttcaag tgcatcccac tctctcagct
121 aatgaagagt ctctctatta tattgaagag ctgatttttc agctgcttaa taaattatgc
181 atggcccagc caaggactgt tcaagatgta gaggagcgag ttcagaagac ctttcctcac
241 ccaattgata aatgggccat tgctgatgca caatctgcta tagaaaaacg aaaacgaaga
301 aatcctcttt tactgcctgt ggacaaaatc catccttcgt tgaaggaagt attagggtac
361 aaagtggact accatgtatc cctatatatt gtggctgtac tagagtatat ctcagctgat
421 attttaaaat tggctggtaa ttatgttttt aatatccggc attatgaaat atctcagcag
481 gacattaaag tgtcaatgtg tgcggataag gttttgatgg acatgtttga tcaggatgac
541 ataggtttgg tttctctctg tgaagatgaa ccctgttctt ctggtgaatt aaactactat
601 gatcttgtca gaactgaaat cgcagaagaa agacagtatc tacgggaatt aaatatgatc
661 ataaaagtgt ttcgagaagc ctttctttct gatagaaagc tgtttaaacc ttctgtatac
721 gaaaagattt ttagtaacat ttcagatata catgaattga ctgtgaaact tttaggtttg
781 attgaagaca cagttgaaat gactgatgaa agcagtcctc atcccttagc tggcagctgt
841 tttgaagatt tggcagaaga gcaagcattt gatccttatg aaacattatc acaggacatt
901 ctttcaccag agtttcatga acatttcaat aaattgatgg ccagacctgc agttgctcta
961 cactttcagt ccattgctga tggttttaaa gaggcagttc gttatgtcct tccacgtctt
1021 atgctggtgc cagtgtatca ctgttggcac tactttgagt tactaaagca attgaaagca
1081 tgtagtgaag aacaagaaga cagagaatgt ttgaaccaag ctattactgc tctcatgaat
1141 caccaaggta gcatggaccg aatttacaag cagtattcac ctagacgtcg acctggagat
1201 cctgtttgcc ctttttatag tcaccaatta agaagcaaac acctggctat caaaaaaatg
1261 aatgaaattc agaaaaatat cgatggatgg gaaggcaaag atattggaca gtgttgtaat
1321 gaattcatta tggagggacc attgacaaga atcggtgcca aacatgaacg gcatattttt
1381 ctgtttgatg gcttaatgat cagttgtaaa cctaatcatg gccagactcg gcttccaggt
1441 tacactagtg cagaatacag gttaaaagaa aaatttgtca tgaggaaaat acaaatttgt
1501 gataaagaag atacttgtga gcacaagcat gcatttgaat tagtatccaa agatgagaac
1561 agcataatat ttgctgctaa gtctgctgaa gaaaaaaaca actggatggc agcccttatt
1621 tctcttcatt atcgtagtac tctagatcga atgttagatt cagtattatt gaaagaagaa
1681 aatgagcaac cactgagatt accaagtcct gaagtatatc gttttgtagt aaaagactct
1741 gaggaaaaca ttgtttttga agacaacttg caaagtagaa gtggcatccc cattattaaa
1801 ggaggaactg tagtgaaatt aattgaaagg ttaacatatc atatgtatgc agatcccaat
1861 tttgttcgta cttttcttac cacatatcgt tcattttgta aaccacagga attgctgagc
1921 ttactgattg aacggtttga aattccagag ccagaaccta ctgacgcaga caaattggca
1981 atagagaaag gcgagcagcc aatcagtgca gaccttaaaa gatttcgcaa ggaatatgtc
2041 caaccagtac aacttagggt acttaatgta ttccgccatt gggttgacca tcattattat
2101 gactttgaaa gagacctgga attgctggaa agactagaat ccttcatttc aagtgtaaga
2161 gggaaagcta tgaaaaaatg ggtagagtca attgctaaga tcatcaggag gaagaagcaa
2221 gctcaggcaa atggagtaag ccataatatt acctttgaaa gtccacctcc accaattgaa
2281 tggcatatca gcaaaccagg acagtttgaa acatttgatc tcatgacact tgatccaata
2341 gaaattgcac gtcagctgac acttttggag tctgatcttt acaggaaagt tcaaccgtct
2401 gaacttgtag ggagtgtgtg gaccaaagaa gataaagaaa taaattctcc aaatttatta
2461 aaaatgattc gccataccac aaatctcacc ctctggtttg aaaaatgcat tgtggaagca
2521 gaaaattttg aagaacgggt ggcagtacta agtagaatta tagaaattct gcaagttttt
2581 caagatttga ataatttcaa tggcgtattg gagatagtca gtgcagtaaa ttcagtgtca
2641 gtatacagac tagaccatac ctttgaggca ctgcaggaaa ggaaaaggaa aattttggac
2701 gaagctgtgg aattaagtca agatcacttt aaaaaatacc tagtaaaact taagtcaatc
2761 aatccacctt gtgtgccttt ttttggaata tatttaacaa atattctgaa gaccgaagaa
2821 gggaataatg attttttaaa aagaaaggga aaagatttaa tcaatttcag taagaggagg
2881 aaagtagctg aaattactgg agaaattcag cagtatcaga atcagcctta ctgtttacgg
2941 atagaaccag atatgaggag attctttgaa aaccttaacc ccatgggaag tgcatctgaa
3001 aaagagttta cagattattt gttcaacaag tcactagaaa ttgaacctcg aaactgcaaa
3061 cagccacctc gatttcctag gaaatcaact ttttccttaa aatctcctgg aataaggcct
3121 aacacaggcc gacatggctc tacctcaggt actttacgag gtcacccaac accattagaa
3181 agagaaccat gtaaaataag ctttagtcgg attgctgaaa ctgagctgga atcaacagtg
3241 tcagcaccaa cctctccaaa tacaccatct actccaccag tatctgcttc ttcagacctt
3301 agtgtatttt tagatgtgga tctcaacagc tcctgtggca gcaatagcat ctttgctcca
3361 gtgcttttgc cacattcaaa gtctttcttt agttcatgtg gtagtttaca taaactaagt
3421 gaagagcccc tgattcctcc tcctcttcct cctcgaaaaa agtttgatca tgatgcttca
3481 aattccaagg gaaatatgaa atctgatgat gatcctcctg ctattccacc gagacagcct
3541 cctcctccaa aggtaaaacc cagagttcct gttcctactg gtgcatttga tgggcctctg
3601 catagtccac ctccgccacc accaagagat cctcttcctg atacccctcc accagttccc
3661 cttcggcctc cagaacactt tataaactgt ccatttaatc ttcagccacc tccactgggg
3721 catcttcaca gagattcaga ctggctcaga gacattagta cgtgtccaaa ttcgccaagc
3781 actcctccta gcacaccctc tccaagggta ccgcgtcgat gctatgtgct cagttctagt
3841 cagaataatc ttgctcatcc tccagctccc cctgttccac caaggcagaa ttcaagccct
3901 catctgccaa aactgccacc aaagacttac aaacgggagc tttcgcaccc cccattgtac
3961 agactgcctt tgctagaaaa tgcagaaact ccccaatga
//