LOCUS       HUMGNEFA                4002 bp    mRNA    linear   HUM 26-JUL-1993
DEFINITION  Human guanine nucleotide exchange factor mRNA, complete cds.
ACCESSION   L13857
VERSION     L13857.1
KEYWORDS    guanine nucleotide exchange factor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4002)
  AUTHORS   Chardin,P., Camonis,J.H., Gale,N.W., van Aelst,L., Schlessinger,J.,
            Wigler,M.H. and Bar-Sagi,D.
  TITLE     Human Sos1: a guanine nucleotide exchange factor for Ras that binds
            to GRB2
  JOURNAL   Science 260 (5112), 1338-1343 (1993)
   PUBMED   8493579
COMMENT     Original source text: Homo sapiens (library: lambda gt10) fetus
            brain cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..4002
                     /db_xref="H-InvDB:HIT000192229"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="brain"
                     /dev_stage="fetus"
                     /tissue_lib="lambda gt10"
     CDS             1..4002
                     /codon_start=1
                     /product="guanine nucleotide exchange factor"
                     /protein_id="AAA35913.1"
                     /translation="MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDA
                     LQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNP
                     LSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQ
                     DIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRE
                     LNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPH
                     PLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEA
                     VQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICS
                     KSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTL
                     TRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTN
                     EYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQ
                     MRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFV
                     RTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYI
                     QPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRK
                     KIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRA
                     VQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII
                     EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKK
                     YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQ
                     QYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKK
                     YSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLT
                     PPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDE
                     VPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSI
                     SDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQ
                     TPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
                     RDGPPLLENAHSS"
BASE COUNT         1341 a          829 c          783 g         1049 t
ORIGIN      
        1 atgcaggcgc agcagctgcc ctacgagttt ttcagcgaag agaacgcgcc caagtggcgg
       61 ggactactgg tgcctgcgct gaaaaaggtc caggggcaag ttcatcctac tctcgagtct
      121 aatgatgatg ctcttcagta tgttgaagaa ttaattttgc aattattaaa tatgctatgc
      181 caagctcagc cccgaagtgc ttcagatgta gaggaacgtg ttcaaaaaag tttccctcat
      241 ccaattgata aatgggcaat agctgatgcc caatcagcta ttgaaaagag gaagcgaaga
      301 aaccctttat ctctcccagt agaaaaaatt catcctttat taaaggaggt cctaggttat
      361 aaaattgacc accaggtttc tgtttacata gtagcagtct tagaatacat ttctgcagac
      421 attttaaagc tggttgggaa ttatgtaaga aatatacggc attatgaaat tacaaaacaa
      481 gatattaaag tggcaatgtg tgctgacaag gtattgatgg atatgtttca tcaagatgta
      541 gaagatatta atatattatc tttaactgac gaagagcctt ccacctcagg agaacaaact
      601 tactatgatt tggtaaaagc atttatggca gaaattcgac aatatataag ggaactaaat
      661 ctaattataa aagtttttag agagcccttt gtctccaatt caaaattgtt ttcagctaat
      721 gatgtagaaa atatatttag tcgcatagta gatatacatg aacttagtgt aaagttactg
      781 ggccatatag aagatacagt agaaatgaca gatgaaggca gtccccatcc actagtagga
      841 agctgctttg aagacttagc agaggaactg gcatttgatc catatgaatc gtatgctcga
      901 gatattttgc gacctggttt tcatgatcgt ttccttagtc agttatcaaa gcctggggca
      961 gcactttatt tgcagtcaat aggcgaaggt ttcaaagaag ctgttcaata tgttttaccc
     1021 aggctgcttc tggcccctgt ttaccactgt ctccattact ttgaactttt gaagcagtta
     1081 gaagaaaaaa gtgaagatca agaagacaag gaatgtttaa aacaagcaat aacagctttg
     1141 cttaatgttc agagtggtat ggaaaaaata tgttctaaaa gtcttgcaaa acgaagactg
     1201 agtgaatctg catgtcggtt ttatagtcag caaatgaagg ggaaacaact agcaatcaag
     1261 aagatgaacg agattcagaa gaatattgat ggttgggagg gaaaagacat tggacagtgt
     1321 tgtaatgaat ttataatgga aggaactctt acacgtgtag gagccaaaca tgagagacac
     1381 atatttctct ttgatggctt aatgatttgc tgtaaatcaa atcatgggca gccaagactt
     1441 cctggtgcta gcaatgcaga atatcgtctt aaagaaaagt tttttatgcg aaaggtacaa
     1501 attaatgata aagatgacac caatgaatac aagcatgctt ttgaaataat tttaaaagat
     1561 gaaaatagtg ttatattttc tgccaagtca gctgaagaga aaaacaattg gatggcagca
     1621 ttgatatctt tacagtaccg gagtacactg gaaaggatgc ttgatgtaac aatgctacag
     1681 gaagagaaag aggagcagat gaggctgcct agtgctgatg tttatagatt tgcagagcct
     1741 gactctgaag agaatattat atttgaagag aacatgcagc ccaaggctgg aattccaatt
     1801 atcaaagcag gaactgttat taaacttata gagaggctta cgtaccatat gtacgcagat
     1861 cccaattttg ttcggacatt tcttacaaca tacagatcct tttgcaaacc tcaagaacta
     1921 ctgagtctta taatagaaag gtttgaaatt ccagagcctg agccaacaga agctgatcgc
     1981 atagctatag agaatggaga tcaacccttg agtgcagaac tgaaaagatt tagaaaagaa
     2041 tatatacagc ctgtgcaact gcgagtatta aatgtatgtc ggcactgggt agagcaccac
     2101 ttctatgatt ttgaaagaga tgcatatctt ttgcaacgaa tggaagaatt tattggaaca
     2161 gtaagaggta aagcaatgaa aaaatgggtt gaatccatca ctaaaataat ccaaaggaaa
     2221 aaaattgcaa gagacaatgg accaggtcat aatattacat ttcagagttc acctcccaca
     2281 gttgagtggc atataagcag acctgggcac atagagactt ttgacctgct caccttacac
     2341 ccaatagaaa ttgctcgaca actcacttta cttgaatcag atctataccg agctgtacag
     2401 ccatcagaat tagttggaag tgtgtggaca aaagaagaca aagaaattaa ctctcctaat
     2461 cttctgaaaa tgattcgaca taccaccaac ctcactctgt ggtttgagaa atgtattgta
     2521 gaaactgaaa atttagaaga aagagtagct gtggtgagtc gaattattga gattctacaa
     2581 gtctttcaag agttgaacaa ctttaatggt gtccttgagg ttgtcagtgc tatgaattca
     2641 tcacctgttt acagactaga ccacacattt gagcaaatac caagtcgcca gaagaaaatt
     2701 ttagaagaag ctcatgaatt gagtgaagat cactataaga aatatttggc aaaactcagg
     2761 tctattaatc caccatgtgt gcctttcttt ggaatttatc tcactaatat cttgaaaaca
     2821 gaagaaggca accctgaggt cctaaaaaga catggaaaag agcttataaa ctttagcaaa
     2881 aggaggaaag tagcagaaat aacaggagag atccagcagt accaaaatca gccttactgt
     2941 ttacgagtag aatcagatat caaaaggttc tttgaaaact tgaatccgat gggaaatagc
     3001 atggagaagg aatttacaga ttatcttttc aacaaatccc tagaaataga accacgaaac
     3061 cctaagcctc tcccaagatt tccaaaaaaa tatagctatc ccctaaaatc tcctggtgtt
     3121 cgtccatcaa acccaagacc aggtaccatg aggcatccca cacctctgca gcaggagcca
     3181 aggaaaatta gttatagtag gatccctgaa agtgaaacag aaagtacagc atctgcacca
     3241 aattctccaa gaacaccgtt aacacctccg cctgcttctg gtgcttccag taccacagat
     3301 gtttgcagtg tatttgattc cgatcattcg agcccttttc actcaagcaa tgataccgtc
     3361 tttatccaag ttactctgcc ccatggccca agatctgctt ctgtatcatc tataagttta
     3421 accaaaggca ctgatgaagt gcctgtccct cctcctgttc ctccacgaag acgaccagaa
     3481 tctgccccag cagaatcttc accatctaag attatgtcta agcatttgga cagtccccca
     3541 gccattcctc ctaggcaacc cacatcaaaa gcctattcac cacgatattc aatatcagac
     3601 cggacctcta tctcagaccc tcctgaaagc cctcccttat taccaccacg agaacctgtg
     3661 aggacacctg atgttttctc aagctcacca ctacatctcc aacctccccc tttgggcaaa
     3721 aaaagtgacc atggcaatgc cttcttccca aacagccctt ccccctttac accacctcct
     3781 cctcaaacac cttctcctca cggcacaaga aggcatctgc catcaccacc attgacacaa
     3841 gaagtggacc ttcattccat tgctgggccg cctgttcctc cacgacaaag cacttctcaa
     3901 catatcccta aactccctcc aaaaacttac aaaagggagc acacacaccc atccatgcac
     3961 agagatggac caccactgtt ggagaatgcc cattcttcct ga
//