LOCUS HUMGOS8PPC 1345 bp mRNA linear HUM 05-MAR-1996
DEFINITION Human helix-loop-helix basic phosphoprotein (G0S8) mRNA, complete
cds.
ACCESSION L13463
VERSION L13463.1
KEYWORDS basic protein; basic-helix-loop-helix protein; helix-loop-helix
protein; phosphoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1345)
AUTHORS Siderovski,D.P., Heximer,S.P. and Forsdyke,D.R.
TITLE A human gene encoding a putative basic helix-loop-helix
phosphoprotein whose mRNA increases rapidly in
cycloheximide-treated blood mononuclear cells
JOURNAL DNA Cell Biol. 13 (2), 125-147 (1994)
PUBMED 8179820
REFERENCE 2 (bases 1 to 1345)
AUTHORS Siderovski,D.P., Hessel,A., Chung,S., Mak,T.W. and Tyers,M.
TITLE A new family of regulators of G-protein-coupled receptors?
JOURNAL Curr. Biol. 6 (2), 211-212 (1996)
PUBMED 8673468
REFERENCE 3 (bases 1 to 1345)
AUTHORS Wu,H.K., Heng,H.H., Shi,X.M., Forsdyke,D.R., Tsui,L.C., Mak,T.W.,
Minden,M.D. and Siderovski,D.P.
TITLE Differential expression of a basic helix-loop-helix phosphoprotein
gene, G0S8, in acute leukemia and localization to human chromosome
1q31
JOURNAL Leukemia 9 (8), 1291-1298 (1995)
PUBMED 7643615
REFERENCE 4 (bases 1 to 1345)
AUTHORS Siderovski,D.P.
TITLE Direct Submission
JOURNAL Submitted (15-AUG-1994) David P. Siderovski, Quantitative Biology,
Amgen Institute, Toronto, ON M5G 2C1, Canada
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1345
/db_xref="H-InvDB:HIT000192204"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="lymphocyte"
/tissue_type="blood"
/dev_stage="adult"
gene 1..1345
/gene="GOS8"
CDS 33..668
/gene="GOS8"
/function="regulator of G-protein signalling"
/note="also called RGS2"
/codon_start=1
/product="helix-loop-helix phosphoprotein"
/protein_id="AAC37587.1"
/translation="MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTR
LSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLK
SEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQ
NIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT"
regulatory 1318..1323
/regulatory_class="polyA_signal_sequence"
/gene="GOS8"
BASE COUNT 443 a 254 c 304 g 344 t
ORIGIN
1 aaaacagccg gggctccagc gggagaacga taatgcaaag tgctatgttc ttggctgttc
61 aacacgactg cagacccatg gacaagagcg caggcagtgg ccacaagagc gaggagaagc
121 gagaaaagat gaaacggacc cttttaaaag attggaagac ccgtttgagc tacttcttac
181 aaaattcctc tactcctggg aagcccaaaa ccggcaaaaa aagcaaacag caagctttca
241 tcaagccttc tcctgaggaa gcacagctgt ggtcagaagc atttgacgag ctgctagcca
301 gcaaatatgg tcttgctgca ttcagggctt ttttaaagtc ggaattctgt gaagaaaata
361 ttgaattctg gctggcctgt gaagacttca aaaaaaccaa atcaccccaa aagctgtcct
421 caaaagcaag gaaaatatat actgacttca tagaaaagga agctccaaaa gagataaaca
481 tagattttca aaccaaaact ctgattgccc agaatataca agaagctaca agtggctgct
541 ttacaactgc ccagaaaagg gtatacagct tgatggagaa caactcttat cctcgtttct
601 tggagtcaga attctaccag gacttgtgta aaaagccaca aatcaccaca gagcctcatg
661 ctacatgaaa tgtaaaaggg agcccagaaa tggaggacat ttcattcttt ttcctgaggg
721 gaaggactgt gacctgccat aaagactgac cttgaattca gcctgggtgt tcaggaaaca
781 tcactcagaa ctattgattc aaagttgggt agtgaatcag gaagccagta actgactagg
841 agaagctggt atcagaacag cttccctcac tgtgtacaga acgcaagaag ggaataggtg
901 gtctgaacgt ggtgtctcac tctgaaaagc aggaatgtaa gatgatgaaa gagacaatgt
961 aatactgttg gtccaaaagc atttaaaatc aatagatctg ggattatgtg gccttaggta
1021 gctggttgta catctttccc taaatcgatc catgttacca catagtagtt ttagtttagg
1081 attcagtaac agtgaagtgt ttactatgtg caagggtatt gaagttctta tgaccacaga
1141 tcatcagtac tgttgtctca tgtaatgcta aaactgaaat ggtccgtgtt tgcattgtta
1201 aaaatgatgt gtgaaataga atgagtgcta tggtgttgaa aactgcagtg tccgttatga
1261 gtgccaaaaa tctgtcttga aggcagctac actttgaagt ggtctttgaa tacttttaat
1321 aaatttattt tgataaataa tattg
//