LOCUS HUMLIS1B 1791 bp mRNA linear HUM 30-SEP-1993
DEFINITION Homo sapiens (clone 47) Miller-Dieker lissencephaly protein (LIS1)
mRNA, complete cds.
ACCESSION L13386
VERSION L13386.1
KEYWORDS Miller-Dieker lissencephaly protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1791)
AUTHORS Reiner,O., Carrozzo,R., Shen,Y., Wehnert,M., Faustinella,F.,
Dobyns,W.B., Caskey,C.T. and Ledbetter,D.H.
TITLE Isolation of a Miller-Dieker lissencephaly gene containing G
protein beta-subunit-like repeats
JOURNAL Nature 364 (6439), 717-721 (1993)
PUBMED 8355785
COMMENT Original source text: Homo sapiens (library: lambda gt10) kidney
cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1791
/db_xref="H-InvDB:HIT000192197"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17p13.3"
/tissue_type="kidney"
/tissue_lib="lambda gt10"
gene 1..1791
/gene="LIS1"
5'UTR 1..453
/gene="LIS1"
CDS 454..1686
/gene="LIS1"
/codon_start=1
/product="Miller-Dieker lissencephaly protein"
/protein_id="AAA02881.1"
/translation="MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELD
KKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKY
ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH
SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM
WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE
HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL
VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA
PYVVTGSVDQTVKVWECR"
3'UTR 1687..1791
/gene="LIS1"
polyA_site 1791
/gene="LIS1"
BASE COUNT 484 a 416 c 440 g 451 t
ORIGIN
1 cggcgagaag gagaaggagg ggagcgctcg ggcgcgagcg agagaaaccg cgagcgccga
61 gcttggactc gagccccgga acggctgagg agcccgcccg ctcccctccc ctccccctcc
121 ccgggcccgg gcccagcgcg ccatcctccc ccctccttcc ctccctccct ccttcctccc
181 tcccctctcc ctccccctcc cccgccggtg gatgggagtg aaggacggaa gaggccctgc
241 ggaggcggcg gtgcagcgct ccggtggaat gaatcttact tgttgaatat cttctggtta
301 ctagttggat tcatttgtga aagaatcatt ttcccctgtg tggaagacac ttagtggcat
361 atttaaatta taagtccacg gatcaaaaag ctttttgatt tcccaaagga gggacatacc
421 actatatcag ataagcttga cattacagcc aagatggtgc tgtcccagag acaacgagat
481 gaactaaatc gagctatagc agattatctt cgttcaaatg gctatgaaga ggcatattca
541 gtttttaaaa aggaagctga attagatgtg aatgaagaat tagataaaaa gtatgctggt
601 cttttggaaa aaaaatggac atctgttatt agattacaaa agaaggttat ggaattagaa
661 tcaaagctaa atgaagcaaa agaagaattt acgtcaggtg gacctcttgg tcagaaacga
721 gacccaaaag aatggattcc ccgtccgcca gaaaaatatg cattgagtgg tcacaggagt
781 ccagtcactc gagtcatttt ccatcctgtg ttcagtgtta tggtctctgc ttcagaggat
841 gctacaatta aggtgtggga ttatgagact ggagattttg aacgaactct taaaggacat
901 acagactctg tacaggacat ttcattcgac cacagcggca agcttctggc ttcctgttct
961 gcagatatga ccattaaact atgggatttt cagggctttg aatgcatcag aaccatgcac
1021 ggccatgacc acaatgtttc ttcagtagcc atcatgccca atggagatca tatagtgtct
1081 gcctcaaggg ataaaactat aaaaatgtgg gaagtgcaaa ctggctactg tgtgaagaca
1141 ttcacaggac acagagaatg ggtacgtatg gtacggccaa atcaagatgg cactctgata
1201 gccagctgtt ccaatgacca gactgtgcgt gtatgggtcg tagcaacaaa ggaatgcaag
1261 gctgagctcc gagagcatga gcatgtggta gaatgcattt cctgggctcc agaaagctca
1321 tattcctcca tctctgaagc aacaggatct gagactaaaa aaagtggtaa acctgggcca
1381 ttcttgctgt ctggatccag agacaagact attaagatgt gggatgtcag tactggcatg
1441 tgccttatga ccctcgtggg tcatgataac tgggtacgtg gagttctgtt ccattctggg
1501 gggaagttta ttttgagttg tgctgatgac aagaccctac gcgtatggga ttacaagaac
1561 aagcgatgca tgaagaccct caatgcgcat gaacactttg ttacctcctt ggatttccac
1621 aagacggcac cctatgtcgt cactggcagc gtagatcaaa cagtaaaagt gtgggagtgc
1681 cgttgatttt gtctccttcg gcccctcctc cctcttttcc tctggatgca ctctgatgat
1741 accatggtta ccccattgag ctctgtttaa ataaatattg tcctttcatg t
//