LOCUS HUMLIS1A 5243 bp mRNA linear HUM 30-SEP-1993
DEFINITION Homo sapiens(clone 71) Miller-Dieker lissencephaly protein (LIS1)
mRNA, complete cds.
ACCESSION L13385
VERSION L13385.1
KEYWORDS Miller-Dieker lissencephaly protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5243)
AUTHORS Reiner,O., Carrozzo,R., Shen,Y., Wehnert,M., Faustinella,F.,
Dobyns,W.B., Caskey,C.T. and Ledbetter,D.H.
TITLE Isolation of a Miller-Dieker lissencephaly gene containing G
protein beta-subunit-like repeats
JOURNAL Nature 364 (6439), 717-721 (1993)
PUBMED 8355785
COMMENT Original source text: Homo sapiens (library: lambda gt10) kidney
cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5243
/db_xref="H-InvDB:HIT000192196"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17p13.3"
/tissue_type="kidney"
/tissue_lib="lambda gt10"
gene 1..5243
/gene="LIS1"
5'UTR 1..217
/gene="LIS1"
CDS 218..1450
/gene="LIS1"
/codon_start=1
/product="Miller-Dieker lissencephaly protein"
/protein_id="AAA02880.1"
/translation="MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELD
KKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKY
ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH
SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM
WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE
HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL
VGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA
PYVVTGSVDQTVKVWECR"
3'UTR 1451..5243
/gene="LIS1"
BASE COUNT 1495 a 963 c 1147 g 1638 t
ORIGIN
1 cggcggaggc ggcggtgcag cgctccggtg gaatgaatct tacttgttga atatcttctg
61 gttactagtt ggattcattt gtgaaagaat cattttcccc tgtgtggaag acacttagtg
121 gcatatttaa attataagtc cacggatcaa aaagcttttt gatttcccaa aggagggaca
181 taccactata tcagataagc ttgacattac agccaagatg gtgctgtccc agagacaacg
241 agatgaacta aatcgagcta tagcagatta tcttcgttca aatggctatg aagaggcata
301 ttcagttttt aaaaaggaag ctgaattaga tgtgaatgaa gaattagata aaaagtatgc
361 tggtcttttg gaaaaaaaat ggacatctgt tattagatta caaaagaagg ttatggaatt
421 agaatcaaag ctaaatgaag caaaagaaga atttacgtca ggtggacctc ttggtcagaa
481 acgagaccca aaagaatgga ttccccgtcc gccagaaaaa tatgcattga gtggtcacag
541 gagtccagtc actcgagtca ttttccatcc tgtgttcagt gttatggtct ctgcttcaga
601 ggatgctaca attaaggtgt gggattatga gactggagat tttgaacgaa ctcttaaagg
661 acatacagac tctgtacagg acatttcatt cgaccacagc ggcaagcttc tggcttcctg
721 ttctgcagat atgaccatta aactatggga ttttcagggc tttgaatgca tcagaaccat
781 gcacggccat gaccacaatg tttcttcagt agccatcatg cccaatggag atcatatagt
841 gtctgcctca agggataaaa ctataaaaat gtgggaagtg caaactggct actgtgtgaa
901 gacattcaca ggacacagag aatgggtacg tatggtacgg ccaaatcaag atggcactct
961 gatagccagc tgttccaatg accagactgt gcgtgtatgg gtcgtagcaa caaaggaatg
1021 caaggctgag ctccgagagc atgagcatgt ggtagaatgc atttcctggg ctccagaaag
1081 ctcatattcc tccatctctg aagcaacagg atctgagact aaaaaaagtg gtaaacctgg
1141 gccattcttg ctgtctggat ccagagacaa gactattaag atgtgggatg tcagtactgg
1201 catgtgcctt atgaccctcg tgggtcatga taactgggta cgtggagttc tgttccattc
1261 tggggggaag tttattttga gttgtgctga tgacaagacc ctacgcgtat gggattacaa
1321 gaacaagcga tgcatgaaga ccctcaatgc gcatgaacac tttgttacct ccttggattt
1381 ccacaagacg gcaccctatg tcgtcactgg cagcgtagat caaacagtaa aagtgtggga
1441 gtgccgttga ttgtgtctcc ttcggcccct cctccctctt ttcctctgga tgcactctga
1501 tgataccatg gttaccccat tgagctctgt ttaaataaat attgtccttt catgtaaatt
1561 attctggatg tagattgagc ttattaaatg ttacacacaa agtattcatg catggtgaat
1621 ccaaattgta tactgtaaat ttacatacgt tgtctagaag taccataggg tttaaaaacc
1681 tgggctggca ttggtcacac caggcctaag aaggcagaag ttgaatcaat tgaactaggg
1741 cactaaactg aatagttgac agtgtcattt tatgttggat tattaattcc tgtttttctt
1801 tctgctatct gttggtgcct gacttgatgg cctcatttgg ggaaaagtgg tggttattag
1861 ggcttttcct gaaatgtgta tctatgtaac atcacttaag tgtgcttaat aaatctcctg
1921 taaggatttt agatgataag gctacaattc agaatcttct gaaccatcta tgtaatgaat
1981 ggggattata cattggaatt tttgtcatga cacatttgcc aaatcagtag gatatatttg
2041 ttttggcagc ctatcacgca gaggctagtg gtatatttat gtaagaaaat gactgtaaat
2101 ctcaagaaaa atctcagcag ctaatagcaa ctcatttatt tcattttggt cttaatgctt
2161 tgtaaacagg tcaaaaaata ctgtcatact ctaagcttct attttccaca ctggacatac
2221 ttctagttgt attctccata ctattagact gtgtagtgat gtgacttcca agtagaattt
2281 aatctcccca ttgagtgtgt catggtacaa atcactattc gtttttggtg ttttttaggg
2341 atgtgcaatg tgcattacat aatgacagaa atactgagaa ggttctgtgt gcccatttga
2401 aaggagtggg aggaatacag cagtttgttt ttcaacatga atctgatatt gatttaaact
2461 gtgtttcact tacaagtttt aaaaaaatga cagggtttaa tggagcgtgc ataaaaatgt
2521 actgttttca ccttttgttt atatgtaaat gtttgtaagt atatgggcct atctgtaagt
2581 gggtaagtct gtatgtgtgt atcatacaca tcaacctcca tgtccttagt cctgggtttt
2641 tgaaaaagtg ctaaaacgga caagtagaat aaatgttgct gtggaatgcc atgctttaga
2701 acaaaccctt tttgatctta atgcttctga aaactaggtc tgactctggg gatttttttc
2761 cagccgaagg aaaatcactt ccgttatgtc cccctctaat ttagccgctc gacattttac
2821 acaacccgga tatgttgtat attttgaccc aaagttacag gtaggtttaa gagaattttt
2881 agccatgact tttggagcac tattccattg tcagttatta ataaagaatt ccattgctta
2941 gctaaccaac aggttttttt tgtttccaag agagttattt gaaaagttaa cagaacaatg
3001 agataacagt gacagtttaa caaagataaa attctgaact gcgttttatt catttgtgta
3061 ctatgtgatt ttttaaatgt cccctttagt atttaatgga aaattggttc ctgcaaaaga
3121 caaagggtga gagttagcgt cctgtagata cacacagaga ctaggccgta tattaactag
3181 aagcagcttt atgtctagct tgtgtctttt tgtttgtttg cttgtttgtt tttagattcc
3241 tgagagatgt ctctggaagg gaaagttttg agaactaatg gctatttttg aggacaaaaa
3301 ttacatctta agctaattcc ttaaatacat acagtaggtg aattttcagg acaatattgc
3361 ctcacaaccc tgcttacatt gaaaagtctt tttcccttag ctcttctgac tggatttttc
3421 tacaaaacta tggaaaatat ctttgttctt gtttgctgct attttctgtc ctattttgag
3481 aaatataaat acatagaaat ggtgcatctt aacatttgtt tgtacatgta taaatgtctt
3541 gtattttaat tcatttttag catgaattgt ttaagggtaa gccacaacat ctagaaatca
3601 ctcatagata ttgaacaata aaggagaatg gtaccgatgc aggaggaagc aagcgtgtct
3661 tcccctgcag cacacagcga cttgcgttga caaaggagga ggaaacgatt actctgtaaa
3721 caaagttatc cttacttggg agattgccac agcctgctgc tgagttgagt taccagacat
3781 cctccatgtg agaagcagcg aacattgaat ctcagggatg gcccacaact gggtccacat
3841 gtaatgagcc ctgtttaata acgaaggggt gggggagagc agtccgtcta caacctggaa
3901 tcagatttgc aaaatttcct gcactgctgt ctgacactgt cctgttgatg ccctttctga
3961 ctgtgttctc tgttttctct gtctgctgtc taaccctgtg ccttgcctgg gataaggaca
4021 atgatgaggt tactggtttg gattgtaagt agaggacttt tattaattgg tttagaggtt
4081 cactgctgct ttgtcacttt ctcaatcaaa ttggccactt aagaaataaa gagctggtag
4141 aattgcatcc tcagatgatt attgactgtg tgtgtgtgtg aaaacagaca ttccagtgcc
4201 acccaaatat atatctgtaa cgtgcccaag aaatcctagc tgcgctcttg agagtgcatg
4261 ccatggagac tggtttagac accgcgtgga gcctagttgc ctgttgtcac ggcatcttgc
4321 actttaggag actaagaccg tcctggttcg tctgtgtgtg gtgtgaccaa tggtgtgccc
4381 agagcactac tctcaaaatc actagtgtta gcaagtcgtc ccgggctggg gagcgttcgc
4441 cgtagtcttt ggaagctttg gctttagatt taccaagccc cgcctccccg ctgccagtgc
4501 cctgctctcc cgttcgcctc tttctgtttc tgtgtgaact ttcccggtaa tatcactcgt
4561 taaataggtt ttctttaaac ttaattaagg aaaaactatt taaaggtaaa ggatattttg
4621 ttgacatcgg tggctcgatc atccttaagc aactgaagtt aaaattgttg aaggaaaagg
4681 cacttaaatt ggttactttc atgtccagct gtatataagt ccagtgtgtt catctagatg
4741 acgcaaagaa tctcctggta gagaagcgac atgtaaaaaa ctggtggaaa aaggttttgg
4801 attttttttc cagtggggtg gggggagggc aagctggatt tacaggtcac ggctggactg
4861 aatgggcctt tttatcttcc cactgtatca tggaagtagc tgcttgcttg tactgtccat
4921 ccttcaggca tccctaaagc tcactctgaa gatgttagag acaaacacaa actcttcgag
4981 ttaaagttga tcctgacact gacatgaagg caagccttga tttcgtatga acgttgctga
5041 agtggtaatt gaggaaaaca gttccccaga ttgttaagag ttcactgaag atattgacac
5101 aattttaaaa aatcagtaaa ggaatgtata taatattgct ctcgtgtttt acagtaagat
5161 ttgttgctct cagactgtgt aaaacaaaat ttattcatgt tttctgcata ttaaaaaatc
5221 ttattgtacc aactggtaaa ccg
//