LOCUS HUMCAMPB 3787 bp mRNA linear HUM 19-AUG-1993
DEFINITION Homo sapiens 3',5'-cyclic AMP phosphodiesterase mRNA, 3'end.
ACCESSION L12686
VERSION L12686.1
KEYWORDS 3',5'-cyclic AMP phosphodiesterase; cAMP phosphodiesterase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3787)
AUTHORS Obernolte,R., Bhakta,S., Alvarez,R., Bach,C., Zuppan,P.,
Mulkins,M., Jarnagin,K. and Shelton,E.R.
TITLE The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE
IV) reveals a multigene family
JOURNAL Gene 129 (2), 239-247 (1993)
PUBMED 8392015
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3787
/db_xref="H-InvDB:HIT000192178"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="43D-Cl2"
/cell_type="lymphocyte"
CDS <69..1889
/note="Rolipram sensitive"
/codon_start=1
/product="3',5'-cyclic AMP phosphodiesterase"
/protein_id="AAA35643.1"
/translation="ITDTSSRRGVGGKLGTSHPRQSTTVICSPGGESWKEGASVQIMK
EHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPS
PTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKW
GLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYH
NSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSE
LALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH
MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD
RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDA
QDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEG
EGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT"
BASE COUNT 1083 a 831 c 829 g 1044 t
ORIGIN
1 tcgctacatg atgactttag aagagaccgt tccctccgcc ttcttcctca gaggaagttt
61 cttggtagat caccgacacc tcatccaggc ggggggttgg ggggaaactt ggcaccagcc
121 atcccaggca gagcaccact gtgatttgtt ctcctggtgg agagagctgg aaggaaggag
181 ccagcgtgca aataatgaag gagcacgggg gcaccttcag tagcaccgga atcagcggtg
241 gtagcggtga ctctgctatg gacagcctgc agccgctcca gcctaactac atgcctgtgt
301 gtttgtttgc agaagaatct tatcaaaaat tagcaatgga aacgctggag gaattagact
361 ggtgtttaga ccagctagag accatacaga cctaccggtc tgtcagtgag atggcttcta
421 acaagttcaa aagaatgctg aaccgggagc tgacacacct ctcagagatg agccgatcag
481 ggaaccaggt gtctgaatac atttcaaata ctttcttaga caagcagaat gatgtggaga
541 tcccatctcc tacccagaaa gacagggaga aaaagaaaaa gcagcagctc atgacccaga
601 taagtggagt gaagaaatta atgcatagtt caagcctaaa caatacaagc atctcacgct
661 ttggagtcaa cactgaaaat gaagatcacc tggccaagga gctggaagac ctgaacaaat
721 ggggtcttaa catctttaat gtggctggat attctcacaa tagaccccta acatgcatca
781 tgtatgctat attccaggaa agagacctcc taaagacatt cagaatctca tctgacacat
841 ttataaccta catgatgact ttagaagacc attaccattc tgacgtggca tatcacaaca
901 gcctgcacgc tgctgatgta gcccagtcga cccatgttct cctttctaca ccagcattag
961 acgctgtctt cacagatttg gagatcctgg ctgccatttt tgcagctgcc atccatgacg
1021 ttgatcatcc tggagtctcc aatcagtttc tcatcaacac aaattcagaa cttgctttga
1081 tgtataatga tgaatctgtg ttggaaaatc atcaccttgc tgtgggtttc aaactgctgc
1141 aagaagaaca ctgtgacatc ttcatgaatc tcaccaagaa gcagcgtcag acactcagga
1201 agatggttat tgacatggtg ttagcaactg atatgtctaa acatatgagc ctgctggcag
1261 acctgaagac aatggtagaa acgaagaaag ttacaagttc aggcgttctt ctcctagaca
1321 actataccga tcgcattcag gtccttcgca acatggtaca ctgtgcagac ctgagcaacc
1381 ccaccaagtc cttggaattg tatcggcaat ggacagaccg catcatggag gaatttttcc
1441 agcagggaga caaagagcgg gagaggggaa tggaaattag cccaatgtgt gataaacaca
1501 cagcttctgt ggaaaaatcc caggttggtt tcatcgacta cattgtccat ccattgtggg
1561 agacatgggc agatttggta cagcctgatg ctcaggacat tctcgatacc ttagaagata
1621 acaggaactg gtatcagagc atgatacctc aaagtccctc accaccactg gacgagcaga
1681 acagggactg ccagggtctg atggagaagt ttcagtttga actgactctc gatgaggaag
1741 attctgaagg acctgagaag gagggagagg gacacagcta tttcagcagc acaaagacgc
1801 tttgtgtgat tgatccagaa aacagagatt ccctgggaga gactgacata gacattgcaa
1861 cagaagacaa gtcccccgtg gatacataat ccccctctcc ctgtggagat gaacattcta
1921 tccttgatga gcatgccagc tatgtggtag ggccagccca ccatgggggc caagacctgc
1981 acaggacaag ggccacctgg cctttcagtt acttgagttt ggagtcagaa agcaagacca
2041 ggaagcaaat agcagctcag gaaatcccac ggttgacttg ccttgatggc aagcttggtg
2101 gagagggctg aagctgttgc tgggggccga ttctgatcaa gacacatggc ttgaaaatgg
2161 aagacacaaa actgagagat cattctgcac taagtttcgg gaacttatcc ccgacagtga
2221 ctgaactcac tgactaataa cttcatttat gaatcttctc acttgtccct ttgtctgcca
2281 acctgtgtgc cttttttgta aaacattttc atgtctttaa aatgcctgtt gaatacctgg
2341 agtttagtat caacttctac acagataagc tttcaaagtt gacaaacttt tttgactctt
2401 tctggaaaag ggaaagaaaa tagtcttcct tctttcttgg gcaatatcct tcactttact
2461 acagttactt ttgcaaacag acagaaagga tacacttcta accacatttt acttccttcc
2521 cctgttgtcc agtccaactc cacagtcact cttaaaactt ctctctgttt gcctgcctcc
2581 aacagtactt ttaacttttt gctgtaaaca gaataaaatt gaacaaatta gggggtagaa
2641 aggagcagtg gtgtcgttca ccgtgagagt ctgcatagaa ctcagcagtg tgccctgctg
2701 tgtcttggac cctgcccccc acaggagttg tacagtccct ggccctgttc cctacctcct
2761 ctcttcaccc cgttaggctg ttttcaatgt aatgctgccg tccttctctt gcactgcctt
2821 ctgcgctaac acctccattc ctgtttataa ccgggtattt attacttaat gtatataatg
2881 taatgttttg taagttatta atttatatat ctaacattgc ctgccaatgg tggtgttaaa
2941 tttgtgtaga aaactctgcc taagagttac gactttttct tgtaatgttt tgtattgtgt
3001 attatataac ccaaacgtca cttagtagag acatatggcc cccttggcag agaggacagg
3061 ggtgggcttt tgttcaaagg gtctgccctt tccctgcctg agttgctact tctgcacaac
3121 ccctttatga accagttttg gaaacaatat tctcacatta gatactaaat ggtttatact
3181 gagcttttac ttttgtatag cttgataggg gcagggggca atgggatgta gtttttaccc
3241 aggttctatc caaatctatg tgggcatgag ttgggttata actggatcct actatcattg
3301 tggctttggt tcaaaaggaa acactacatt tgctcacaga tgattcttct gaatgctccc
3361 gaactactga ctttgaagag gtagcctcct gcctgccatt aagcaggaat gtcatgttcc
3421 agttcattac aaaagaaaac aataaaacaa tgtgaatttt tataataaaa tgtgaactga
3481 tgtagcaaat tacgcaaatg tgaagcctct tctgataaca cttgttaggc ctcttactga
3541 tgtcagtttc agtttgtaaa atatgtttca tgctttcagt tcagcattgt gactcagtaa
3601 ttacagaaaa tggcacaaat gtgcatgacc aatgtatgtc tatgaacact gcattgtttc
3661 aggtggacat tttatcattt tcaaatgttt ctcacaatgt atgttatagt attattatta
3721 tatattgtgt tcaaatgcat tctaaagaga cttttatatg aggtgaataa agaaaagcat
3781 gattaga
//