LOCUS HUMD4C 1504 bp mRNA linear HUM 27-FEB-2002
DEFINITION Homo sapiens dopamine receptor D4 (DRD4) mRNA, complete cds.
ACCESSION L12398 X58497
VERSION L12398.1
KEYWORDS dopamine D4 receptor; dopamine receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1504)
AUTHORS Van Tol,H.H., Bunzow,J.R., Guan,H.C., Sunahara,R.K., Seeman,P.,
Niznik,H.B. and Civelli,O.
TITLE Cloning of the gene for a human dopamine D4 receptor with high
affinity for the antipsychotic clozapine
JOURNAL Nature 350 (6319), 610-614 (1991)
PUBMED 1840645
REFERENCE 2 (bases 1 to 1504)
AUTHORS Van Tol,H.H., Wu,C.M., Guan,H.C., Ohara,K., Bunzow,J.R.,
Civelli,O., Kennedy,J., Seeman,P., Niznik,H.B. and Jovanovic,V.
TITLE Multiple dopamine D4 receptor variants in the human population
JOURNAL Nature 358 (6382), 149-152 (1992)
PUBMED 1319557
COMMENT On Feb 26, 2002 this sequence version replaced gi:30414.
FEATURES Location/Qualifiers
source 1..1504
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p15.5"
gene 1..1504
/gene="DRD4"
CDS 1..1404
/gene="DRD4"
/codon_start=1
/product="dopamine receptor D4"
/protein_id="AAB59386.1"
/db_xref="GDB:G00-127-782"
/translation="MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLL
IGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWL
LSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATW
LLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRG
LQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGP
DCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLP
QDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA
MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTV
FNAEFRNVFRKALRACC"
repeat_region 744..1080
/gene="DRD4"
/note="the 48bp direct repeat unit is polymorphic with
respect to the number of repeated units (7 units for D4.7)
(-8 &10 units; cit. #2; feature c) and seq. of the
individual units (feature e, unpubl.); G00-127-782"
/rpt_type=direct
/rpt_unit_range=744..792
variation 791..1033
/gene="DRD4"
/note="this sequence was deleted in the D4 variant with a
2-fold repeat (D4.2); this polymorphic variant was
isolated as a partial cDNA from the neuroepithelioma
SK-N-MC (see cit #3); G00-127-782"
/phenotype="dopamine D4.2 receptor"
/replace="cc"
variation 839..985
/gene="DRD4"
/note="this group of nucleotides is deleted in the
polymorphic variant of the D4 receptor with a 4-fold
repeat (D4.4); isolated as a partial cDNA from human
pituitary and substantia nigra cDNA library; G00-127-782"
/phenotype="dopamine D4.4 receptor"
/replace="cc"
variation 985
/gene="DRD4"
/note="G00-127-782"
/phenotype="dopamine D4.4 receptor"
/replace="g"
variation 994
/gene="DRD4"
/note="G00-127-782"
/phenotype="dopamine D4.4 receptor"
/replace="a"
polyA_site 1504
/gene="DRD4"
/experiment="experimental evidence, no additional details
recorded"
/note="four independently isolated cDNA clones contain a
poly A tail after this nucleotide; G00-127-782"
BASE COUNT 153 a 633 c 487 g 231 t
ORIGIN
1 atggggaacc gcagcaccgc ggacgcggac gggctgctgg ctgggcgcgg gccggccgcg
61 ggggcatctg cgggggcatc tgcggggctg gctgggcagg gcgcggcggc gctggtgggg
121 ggcgtgctgc tcatcggcgc ggtgctcgcg gggaactcgc tcgtgtgcgt gagcgtggcc
181 accgagcgcg ccctgcagac gcccaccaac tccttcatcg tgagcctggc ggccgccgac
241 ctcctcctcg ctctcctggt gctgccgctc ttcgtctact ccgaggtcca gggtggcgcg
301 tggctgctga gcccccgcct gtgcgacgcc ctcatggcca tggacgtcat gctgtgcacc
361 gcctccatct tcaacctgtg cgccatcagc gtggacaggt tcgtggccgt ggccgtgccg
421 ctgcgctaca accggcaggg tgggagccgc cggcagctgc tgctcatcgg cgccacgtgg
481 ctgctgtccg cggcggtggc ggcgcccgta ctgtgcggcc tcaacgacgt gcgcggccgc
541 gaccccgccg tgtgccgcct ggaggaccgc gactacgtgg tctactcgtc cgtgtgctcc
601 ttcttcctac cctgcccgct catgctgctg ctctactggg ccacgttccg cggcctgcag
661 cgctgggagg tggcacgtcg cgccaagctg cacggccgcg cgccccgccg acccagcggc
721 cctggcccgc cttcccccac gccacccgcg ccccgcctcc cccaggaccc ctgcggcccc
781 gactgtgcgc cccccgcgcc cggccttccc cggggtccct gcggccccga ctgtgcgccc
841 gccgcgcccg gcctcccccc ggacccctgc ggccccgact gtgcgccccc cgcgcccggc
901 ctcccccagg acccctgcgg ccccgactgt gcgccccccg cgcccggcct tccccggggt
961 ccctgcggcc ccgactgtgc gccccccgcg cccggcctcc cccaggaccc ctgcggcccc
1021 gactgtgcgc cccccgcgcc cggcctcccc ccggacccct gcggctccaa ctgtgctccc
1081 cccgacgccg tcagagccgc cgcgctccca ccccagactc caccgcagac ccgcaggagg
1141 cggcgtgcca agatcaccgg ccgggagcgc aaggccatga gggtcctgcc ggtggtggtc
1201 ggggccttcc tgctgtgctg gacgcccttc ttcgtggtgc acatcacgca ggcgctgtgt
1261 cctgcctgct ccgtgccccc gcggctggtc agcgccgtca cctggctggg ctacgtcaac
1321 agcgccctca accccgtcat ctacactgtc ttcaacgccg agttccgcaa cgtcttccgc
1381 aaggccctgc gtgcctgctg ctgagccggg cacccccgga cgccccccgg cctgatggcc
1441 aggcctcagg gaccaaggag atggggaggg cgcttttgta cgttaattaa acaaattcct
1501 tccc
//