LOCUS       HUMGGFB                 1199 bp    mRNA    linear   HUM 12-JUN-1993
DEFINITION  Human recombinant glial growth factor mRNA, complete cds and
            flanking region.
ACCESSION   L12261
VERSION     L12261.1
KEYWORDS    glial growth factor; neuregulin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Marchionni,M.A., Goodearl,A.D.G., Chen,M., Bermingham-McDonogh,O.,
            Kirk,C., Hendricks,M., Danehy,F., Misumi,D., Sudhalter,J.,
            Kobayashi,K., Wroblewski,D., Lynch,C., Baldasarre,M., Hiles,I.,
            Davis,J.B., Hsuan,J., Totty,N.F., Otsu,M., McBurney,R.N.,
            Waterfield,M.D., Stroobant,P. and Gwynne,D.
  TITLE     Glial growth factors are alternatively spliced erbB2 ligands
            expressed in the nervous system
  JOURNAL   Nature 362 (6418), 312-318 (1993)
   PUBMED   8096067
COMMENT     Original source text: Homo sapiens fetal brain mRNA.
FEATURES             Location/Qualifiers
     source          1..1199
                     /db_xref="H-InvDB:HIT000192168"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="brain"
                     /dev_stage="fetal"
     5'UTR           1..393
     CDS             394..1119
                     /function="Schwann cell mitogen"
                     /standard_name="GGFHFB1"
                     /standard_name="neuregulin"
                     /note="epidermal growth factor (EGF) domain (934..1083);
                     immunoglobulin domain (493..793); expressed in nervous
                     system: spinal cord and brain; same (or homologous) gene
                     produces glial growth factor 2, heregulins, neu
                     differentiation factor and ARIA by alternative splicing"
                     /codon_start=1
                     /product="recombinant glial growth factor"
                     /protein_id="AAB59358.1"
                     /translation="MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKS
                     QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKA
                     SLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVST
                     EGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTG
                     DRCQNYVMASFYSTSTPFLSLPE"
     variation       506
                     /note="CGA to CAA variant noted between rhGGF2 and
                     GGFHFB1; and between heregulins alpha and beta(1-3)"
                     /replace="a"
     3'UTR           1120..1199
BASE COUNT          308 a          337 c          335 g          219 t
ORIGIN      
        1 gcgcggaggc caggagctga gcggcggcgg ctgccggacg atgggagcgt gagcaggacg
       61 gtgataacct ctccccgatc gggttgcgag ggcgccgggc agaggccagg acgcgagccg
      121 ccagcggcgg gacccatcga cgacttcccg gggcgacagg agcagccccg agagccaggg
      181 cgagcgcccg ttccaggtgg ccggaccgcc cgccgcgtcc gcgccgcgct ccctgcaggc
      241 aacgggagac gcccccgcgc agcgcgagcg cctcagcgcg gccgctcgct ctccccatcg
      301 agggacaaac ttttcccaaa cccgatccga gcccttggac caaactcgcc tgcgccgaga
      361 gccgtccgcg tagagcgctc cgtctccggc gagatgtccg agcgcaaaga aggcagaggc
      421 aaagggaagg gcaagaagaa ggagcgaggc tccggcaaga agccggagtc cgcggcgggc
      481 agccagagcc cagccttgcc tccccgattg aaagagatga aaagccagga atcggctgca
      541 ggttccaaac tagtccttcg gtgtgaaacc agttctgaat actcctctct cagattcaag
      601 tggttcaaga atgggaatga attgaatcga aaaaacaaac cacaaaatat caagatacaa
      661 aaaaagccag ggaagtcaga acttcgcatt aacaaagcat cactggctga ttctggagag
      721 tatatgtgca aagtgatcag caaattagga aatgacagtg cctctgccaa tatcaccatc
      781 gtggaatcaa acgagatcat cactggtatg ccagcctcaa ctgaaggagc atatgtgtct
      841 tcagagtctc ccattagaat atcagtatcc acagaaggag caaatacttc ttcatctaca
      901 tctacatcca ccactgggac aagccatctt gtaaaatgtg cggagaagga gaaaactttc
      961 tgtgtgaatg gaggggagtg cttcatggtg aaagaccttt caaacccctc gagatacttg
     1021 tgcaagtgcc caaatgagtt tactggtgat cgctgccaaa actacgtaat ggccagcttc
     1081 tacagtacgt ccactccctt tctgtctctg cctgaatagg agcatgctca gttggtgctg
     1141 ctttcttgtt gctgcatctc ccctcagatt ccacctagag ctagatgtgt cttaccaga
//