LOCUS HUMPP2A72 2338 bp mRNA linear HUM 18-JUN-1996
DEFINITION Homo sapiens protein phosphatase 2A 72 kDa regulatory subunit mRNA,
complete cds.
ACCESSION L12146
VERSION L12146.1
KEYWORDS phosphoprotein phosphohydrolase; protein phosphatase 2A; protein
phosphatase 2A 72 kDa regulatory subunit; regulatory subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2338)
AUTHORS Hendrix,P., Mayer-Jackel,R.E., Cron,P., Goris,J., Hofsteenge,J.,
Merlevede,W. and Hemmings,B.A.
TITLE Structure and expression of a 72-kDa regulatory subunit of protein
phosphatase 2A. Evidence for different size forms produced by
alternative splicing
JOURNAL J. Biol. Chem. 268 (20), 15267-15276 (1993)
PUBMED 8392071
COMMENT Original source text: Homo sapiens (library: lambda ZAP;
Stratagene) female heart muscle cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2338
/db_xref="H-InvDB:HIT000192149"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR 1..260
CDS 261..1850
/EC_number="3.1.3.16"
/codon_start=1
/product="protein phosphatase 2A 72 kDa regulatory
subunit"
/protein_id="AAB02614.1"
/translation="MMIKETSLRRDPDLRGELAFLARGCDFVLPSRFKKRLKSFQQTQ
IQNKPEKKPGTPLPPPATSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPDTCS
NHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQ
SFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAP
EFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSY
EHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGR
MSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGI
EPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFA
VQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKS
NKILSASLPEKCGKLQSVDEE"
misc_feature 393..2331
/note="region homologous to PR130 gene alternatively
spliced form"
3'UTR 1848..2338
regulatory 2317..2322
/regulatory_class="polyA_signal_sequence"
BASE COUNT 694 a 497 c 526 g 621 t
ORIGIN
1 gaattccgca gctgtgttta taacttgaaa attatgagca ggtattggga gccacagact
61 gtatttggga acagctgcat gtcaggacaa gcatagattg tggtctgtgg aggctgggag
121 agcacaatgc ttgaatttca tttctttggg agataagaag aaaaaatacc ttcctacctg
181 acaagattga caacttgcta aatctgatta tcttcagaag tgtgctggac agttgcgaag
241 taaacattta cttttcaaag atgatgatca aggaaacatc tctacgaagg gacccggatt
301 taaggggaga gctagctttc ctggcaaggg gctgtgattt tgttctccct tcacggttta
361 agaagcggct gaagtcattt cagcagacac agattcaaaa taaaccagaa aagaaacctg
421 gaacaccact cccacctcca gccacctctc caagtagtcc ccgacctctc tccccggttc
481 cccatgtgaa taatgttgtg aatgcgccat tgtccataaa cattccacgg ttctactttc
541 ctgaaggact cccagatacc tgtagtaatc atgaacaaac tctaagcaga attgaaactg
601 ctttcatgga tattgaagaa cagaaagcag acatttatga aatggggaaa attgcaaagg
661 tctgtggctg tcctctctat tggaaagccc ccatgttcag ggctgcaggg ggagagaaga
721 caggatttgt gacagcacag tcattcattg ccatgtggag aaagttgctg aataaccatc
781 atgatgatgc ctctaaattc atctgtcttc tagcaaagcc caactgcagc tctctagaac
841 aggaggattt catccctcta cttcaggatg tggtggatac ccaccctggt ctcacgttcc
901 tgaaagatgc tccagaattc cactcccgct acatcaccac ggttattcag agaatattct
961 acacagtcaa cagatcttgg agtggaaaaa ttacttcgac agagataaga aaaagcaact
1021 ttttgcaaac cctagcactt ttggaagaag aggaagatat aaaccaaatt acagattact
1081 tctcctatga acatttctat gttatttatt gtaaattctg ggaactagat actgatcacg
1141 acctctacat cagccaggcc gatctgtctc gatacaatga ccaggcttca tcaagcagga
1201 ttattgaaag gatattctct ggtgcagtaa caaggggaaa aacaatacag aaagagggaa
1261 gaatgagcta tgcagatttt gtttggtttt tgatctctga agaagacaaa aggaatccta
1321 ccagcattga gtattggttc cgctgcatgg atgtggatgg agacggtgta ctctccatgt
1381 atgagctgga gtacttctat gaggagcagt gtgaacggat ggaagccatg ggaattgagc
1441 ccttgccatt ccatgattta ctgtgccaga tgcttgacct agtgaagcca gctgttgatg
1501 gcaaaataac tctaagagat ctgaagaggt gcagaatggc tcacatcttc tatgacactt
1561 tctttaatct ggagaaatac ttagaccatg aacagagaga tccctttgcg gtccagaagg
1621 atgttgagaa cgatgggcct gagccctcag actgggaccg gtttgccgct gaggagtatg
1681 agacgcttgt tgcagaggaa tctgcccaag cacaattcca ggaaggcttt gaagattatg
1741 aaacagatga acctgcctct ccctctgaat ttggaaacaa aagcaataaa atattaagtg
1801 caagccttcc agagaaatgt ggaaagcttc aatcagtgga tgaagaatag ctgccggtgt
1861 ctacaatgaa acgaagatgt gtattttaaa tgtttctttc ttgtgaagag atgttctcgt
1921 ttgcatactg ctttttaaag actttgattt ctccaagtgt gtatcatctg cactaggaac
1981 tttgttttta agcaataggt ctggatacac atttaactta ggaggctcct ccaatttgcc
2041 tcaaacctct tacggagctt ctcctcagaa gtggtaccat cgccttccaa agtcagcact
2101 ctacactctt gaatgtacca aggatctctt ggcgacagta ccaagcacgg ttctctacac
2161 aggtgactga agttgcctct gtgttggctg gcatccctga gtcccctccg gctcctatgg
2221 agcctagaag aaaccttcac ttgcagaaaa cttgagtcag aaaattctgg aacttgaaaa
2281 agtagtaagg gcctccagaa ttgacttagc cctagtaata aaagcactgc cggaattc
//