LOCUS       HUMHSLA                 3255 bp    DNA     linear   HUM 13-JUL-1995
DEFINITION  Human hormone-sensitive lipase (LIPE) gene, complete cds.
ACCESSION   L11706
VERSION     L11706.1
KEYWORDS    hormone-sensitive lipase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Langin,D., Laurell,H., Holst,L.S., Belfrage,P. and Holm,C.
  TITLE     Gene organization and primary structure of human hormone-sensitive
            lipase: possible significance of a sequence homology with a lipase
            of Moraxella TA144, an antarctic bacterium
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (11), 4897-4901 (1993)
   PUBMED   8506334
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Holm,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAR-1993) Cecilia Holm, Cell and Molecular Biology,
            University of Lund, PO. Box 94, Lund, S-221 00, Sweden
COMMENT     On Jul 13, 1995 this sequence version replaced gi:895926.
            Original source text: Homo sapiens male adult DNA.
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="19q13.1-q13.2"
                     /sex="male"
                     /cell_type="lymphocyte"
                     /dev_stage="adult"
     exon            1..1147
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=1
     5'UTR           1..631
                     /gene="LIPE"
                     /note="G00-120-154"
     gene            join(632..1147,1148..1238,1239..1384,1385..1570,
                     1571..1865,1866..2093,2094..2270,2271..2695,2696..2959)
                     /gene="LIPE"
     CDS             join(632..1147,1148..1238,1239..1384,1385..1570,
                     1571..1865,1866..2093,2094..2270,2271..2695,2696..2959)
                     /gene="LIPE"
                     /codon_start=1
                     /product="hormone-sensitive lipase"
                     /protein_id="AAA69810.1"
                     /db_xref="GDB:G00-120-154"
                     /translation="MDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQA
                     LGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFF
                     RTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLH
                     KGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAID
                     PELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEM
                     PLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWP
                     RPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPR
                     ALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMA
                     AYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLV
                     RRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLG
                     TDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAK
                     NELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSL
                     PPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAE
                     LCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH"
     exon            1148..1238
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=2
     exon            1239..1384
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=3
     exon            1385..1570
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=4
     exon            join(1571..1633,1637..1865)
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=5
     exon            1866..2093
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=6
     exon            2094..2270
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=7
     exon            2271..2695
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=8
     exon            join(2696..2778,2781..2837,2839..3255)
                     /gene="LIPE"
                     /product="hormone-sensitive lipase"
                     /note="G00-120-154"
                     /number=9
     3'UTR           2960..3255
                     /gene="LIPE"
                     /note="G00-120-154"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPE"
                     /note="G00-120-154"
BASE COUNT          610 a         1057 c         1015 g          573 t
ORIGIN      
        1 aggaaagatg ggaagggggc cccgactcct gggtcctgag aatggggacc aactggaggt
       61 ttagacttct tggaatctag gagaaggagt cttgggcccc aggagaattc atggagacag
      121 gtgactagac tcttgggttc ctggaaggaa gaaagaagga ccggcagcct cctggatcac
      181 aggagaggtg aatgagttag ggaagcagag tcgtgtgggc tcagggaatg tccggattcg
      241 aggaggccag ggcagcaagt ttctgagtcc caaagaggtg atagcagggg ctcctgggtc
      301 ctgaagagga agggcttggg gcttggactc ctgggtctga gggaggaggg agctgagggc
      361 ccaaactcct ggctcccgag gagggtcaaa ggcactggga actggggccc ccaaacttct
      421 gattcccaga gacaagaggg tgacccctct tatgtctaag gaggaggaac ctgggtcctg
      481 ggccctggaa ctgaaagaag acagcactga ggtttgaagg aggagtgggt aagctatgcc
      541 cagactcctg ggccccagct aagcaaggct tgatccagcc ccacctaaca ggcctcccca
      601 cctgcccaca gcctcaaggc tcatccacaa catggacctg cgcacaatga cacagtcgct
      661 ggtgactctg gcggaggaca acatagcctt cttctcgagc cagggtcctg gggaaacggc
      721 ccagcggctg tcaggcgttt ttgccggtgt acgggagcag gcgctggggc tggagccggc
      781 cctgggccgc ctgctgggtg tggcgcacct ctttgacctg gacccagaga caccggccaa
      841 cgggtaccgc agcctagtgc acacagcccg ctgctgcctg gcgcacctcc tgcacaaatc
      901 ccgctatgtg gcctccaacc gccgcagcat cttcttccgc accagccaca acctggccga
      961 gctggaggcc tacctggctg ccctcaccca gctccgcgct ctggtctact acgcccagcg
     1021 cctgctggtt accaatcggc cgggggtact cttctttgag ggcgacgagg ggctcaccgc
     1081 cgacttcctc cgggagtatg tcacgctgca taagggatgc ttctatggcc gctgcctggg
     1141 cttccagttc acgcctgcca tccggccatt cctgcagacc atctccattg ggctggtgtc
     1201 cttcggggag cactacaaac gcaacgagac aggcctcagt gtggccgcca gctctctctt
     1261 caccagcggc cgctttgcca tcgaccccga gctgcgtggg gctgagtttg agcggatcac
     1321 acagaacctg gacgtgcact tctggaaagc cttctggaac atcaccgaga tggaagtgct
     1381 atcgtctctg gccaacatgg catcggccac cgtgagggta agccgcctgc tcagcctgcc
     1441 acccgaagcc tttgagatgc cactgactgc cgaccccacg ctcacggtca ccatctcacc
     1501 cccactggcc cacacaggcc ctgggcccgt cctcgtcagg ctcatctcct atgacctgcg
     1561 tgaaggacag gacagtgagg agctcagcag cctgataaag tccaacggcc aacggagcct
     1621 ggagctgtgg ccgcgccccc agcaggcacc ccgctcgcgg tccctgatag tgcacttcca
     1681 cggcggtggc tttgtggccc agacctccag atcccacgag ccctacctca agagctgggc
     1741 ccaggagctg ggcgccccca tcatctccat cgactactcc ctggcccctg aggccccctt
     1801 cccccgtgcg ctggaggagt gcttcttcgc ctactgctgg gccatcaagc actgcgccct
     1861 ccttggctca acaggggaac gaatctgcct tgcgggggac agtgcaggcg ggaacctctg
     1921 cttcaccgtg gctcttcggg cagcagccta cggggtgcgg gtgccagatg gcatcatggc
     1981 agcctacccg gccacaatgc tgcagcctgc cgcctctccc tcccgcctgc tgagcctcat
     2041 ggaccccttg ctgcccctca gtgtgctctc caagtgtgtc agcgcctatg ctggtgcaaa
     2101 gacggaggac cactccaact cagaccagaa agccctcggc atgatggggc tggtgcggcg
     2161 ggacacagcc ctgctcctcc gagacttccg cctgggtgcc tcctcatggc tcaactcctt
     2221 cctggagtta agtgggcgca agtcccagaa gatgtcggag cccatagcag agccgatgcg
     2281 ccgcagtgtg tctgaagcag cactggccca gccccagggc ccactgggca cggattccct
     2341 caagaacctg accctgaggg acttgagcct gaggggaaac tccgagacgt cgtcggacac
     2401 ccccgagatg tcgctgtcag ctgagacact tagcccctcc acaccctccg atgtcaactt
     2461 cttattacca cctgaggatg caggggaaga ggctgaggcc aaaaatgagc tgagccccat
     2521 ggacagaggc ctgggcgtcc gtgccgcctt ccccgagggt ttccaccccc gacgctccag
     2581 ccagggtgcc acacagatgc ccctctactc ctcacccata gtcaagaacc ccttcatgtc
     2641 gccgctgctg gcacccgaca gcatgctcaa gagcctgcca cctgtgcaca tcgtggcgtg
     2701 cgcgctggac cccatgctgg acgactcggt catgctcgcg cggcgactgc gcaacctggg
     2761 ccagccggtg acgctgcgcg tggtggagga cctgccgcac ggcttcctga ccctagcggc
     2821 gctgtgccgc gagacgcgcc aggccgcaga gctgtgcgtg gagcgcatcc gcctcgtcct
     2881 cactcctccc gccggagccg ggccgagcgg ggagacgggg gctgcggggg tagacggggg
     2941 ctgcgggggg cgacactaaa agcctgttgt tcccatctgc gccggcctcc gtcatgaatg
     3001 ccttccgggc cgggcggaag gggacgcggg ctgtgcttac ttaagtcggg ggtggcaagg
     3061 gggcggggcg ggggccgaaa gctgagaccc tcgccacggg gagggggacg cgcacacaca
     3121 ccggtcaccg agacggctgg acctgcacgc caccgctgcc ttttgctgct gctgctgcgg
     3181 cgaccgccgc agggacgggg actggccctc ccttgcaggt cggtttggtt tgttgtaaat
     3241 aaaagtattt aatta
//