LOCUS HUMMERLIN 2257 bp mRNA linear HUM 16-JUN-1994
DEFINITION Human moesin-ezrin-radixin-like protein mRNA, complete cds.
ACCESSION L11353
VERSION L11353.1
KEYWORDS cytoskeletal protein; moesin-ezrin-radixin-like protein; oncogene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2257)
AUTHORS Trofatter,J.A., MacCollin,M.M., Rutter,J.L., Murrell,J.R.,
Duyao,M.P., Parry,D.N., Eldridge,R., Kley,N., Menon,A.G.,
Pulaski,K., Kaase,V.H., Ambrose,C.M., Munroe,D., Bove,C.,
Haines,J.L., Martuza,R.L., MacDonald,M.E., Seizinger,B.R.,
Short,M.P., Buckler,A.J. and Gusella,J.F.
TITLE A novel moesin-, ezrin-, radixin-like gene is a candidate for the
neurofibromatosis 2 tumor suppressor
JOURNAL Cell 72 (5), 791-800 (1993)
PUBMED 8453669
COMMENT Original source text: Homo sapiens adult frontal cortex cDNA to
mRNA.
FEATURES Location/Qualifiers
source 1..2257
/db_xref="H-InvDB:HIT000192057"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="frontal cortex"
/dev_stage="adult"
CDS 220..2007
/standard_name="Merlin"
/note="neurofibromatosis 2 related"
/codon_start=1
/product="moesin-ezrin-radixin-like protein"
/protein_id="AAA36212.1"
/translation="MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGK
DLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYP
ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKR
GFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
VNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPL
DKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQM
ERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITE
EEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKE
ADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFD
FKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENS
DRGGSSKHNTIKKLTLQSAKSRVAFFEEL"
polyA_site 2231
/note="putative"
BASE COUNT 611 a 556 c 654 g 436 t
ORIGIN
1 acggcagccg tcagggaccg tcccccaact cccctttccg ctcaggcagg gtcctcgcgg
61 cccatgctgg ccgctgggga cccgcgcagc ccagaccgtt cccgggccgg ccagccggca
121 ccatggtggc cctgaggcct gtgcagcaac tccagggggg ctaaagggct cagagtgcag
181 gccgtggggc gcgagggtcc cgggcctgag ccccgcgcca tggccggggc catcgcttcc
241 cgcatgagct tcagctctct caagaggaag caacccaaga cgttcaccgt gaggatcgtc
301 accatggacg ccgagatgga gttcaattgc gagatgaagt ggaaagggaa ggacctcttt
361 gatttggtgt gccggactct ggggctccga gaaacctggt tctttggact gcagtacaca
421 atcaaggaca cagtggcctg gctcaaaatg gacaagaagg tactggatca tgatgtttca
481 aaggaagaac cagtcacctt tcacttcttg gccaaatttt atcctgagaa tgctgaagag
541 gagctggttc aggagatcac acaacattta ttcttcttac aggtaaagaa gcagatttta
601 gatgaaaaga tctactgccc tcctgaggct tctgtgctcc tggcttctta cgccgtccag
661 gccaagtatg gtgactacga ccccagtgtt cacaagcggg gatttttggc ccaagaggaa
721 ttgcttccaa aaagggtaat aaatctgtat cagatgactc cggaaatgtg ggaggagaga
781 attactgctt ggtacgcaga gcaccgaggc cgagccaggg atgaagctga aatggaatat
841 ctgaagatag ctcaggacct ggagatgtac ggtgtgaact actttgcaat ccggaataaa
901 aagggcacag agctgctgct tggagtggat gccctggggc ttcacattta tgaccctgag
961 aacagactga cccccaagat ctccttcccg tggaatgaaa tccgaaacat ctcgtacagt
1021 gacaaggagt ttactattaa accactggat aagaaaattg atgtcttcaa gtttaactcc
1081 tcaaagcttc gtgttaataa gctgattctc cagctatgta tcgggaacca tgatctattt
1141 atgaggagaa ggaaagccga ttctttggaa gttcagcaga tgaaagccca ggccagggag
1201 gagaaggcta gaaagcagat ggagcggcag cgcctcgctc gagagaagca gatgagggag
1261 gaggctgaac gcacgaggga tgagttggag aggaggctgc tgcagatgaa agaagaagca
1321 acaatggcca acgaagcact gatgcggtct gaggagacag ctgacctgtt ggctgaaaag
1381 gcccagatca ccgaggagga ggcaaaactt ctggcccaga aggccgcaga ggctgagcag
1441 gaaatgcagc gcatcaaggc cacagcgatt cgcacggagg aggagaagcg cctgatggag
1501 cagaaggtgc tggaagccga ggtgctggca ctgaagatgg ctgaggagtc agagaggagg
1561 gccaaagagg cagatcagct gaagcaggac ctgcaggaag cacgcgaggc ggagcgaaga
1621 gccaagcaga agctcctgga gattgccacc aagcccacgt acccgcccat gaacccaatt
1681 ccagcaccgt tgcctcctga cataccaagc ttcaacctca ttggtgacag cctgtctttc
1741 gacttcaaag atactgacat gaagcggctt tccatggaga tagagaaaga aaaagtggaa
1801 tacatggaaa agagcaagca tctgcaggag cagctcaatg aactcaagac agaaatcgag
1861 gccttgaaac tgaaagagag ggagacagct ctggatattc tgcacaatga gaactccgac
1921 aggggtggca gcagcaagca caataccatt aaaaagctca ccttgcagag cgccaagtcc
1981 cgagtggcct tctttgaaga gctctagcag gtgacccagc caccccagga cctgccactt
2041 ctcctgctac cgggaccgcg ggatggacca gatatcaaga gagccatcca tagggagctg
2101 gctgggggtt tccgtgggag ctccagaact ttccccagct gagtgaagag cccagcccct
2161 cttatgtgca attgccttga actacgaccc tgtagagatt tctctcatgg cgttctagtt
2221 ctctgacctg agtctttgtt ttaagaagta tttgtct
//