LOCUS HUMF16BPA 1401 bp mRNA linear HUM 22-JUL-1993
DEFINITION Human fructose-1,6-bisphosphatase homotetramer gene, complete cds.
ACCESSION L10320
VERSION L10320.1
KEYWORDS fructose-1,6-bisphosphatase; homotetramer.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Solomon,D.H., Raynal,M.C., Tejwani,G.A. and Cayre,Y.E.
TITLE Activation of the fructose 1,6-bisphosphatase gene by
1,25-dihydroxyvitamin D3 during monocytic differentiation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (18), 6904-6908 (1988)
PUBMED 2842796
REFERENCE 2 (bases 1 to 1401)
AUTHORS el-Maghrabi,M.R., Gidh-Jain,M., Austin,L.R. and Pilkis,S.J.
TITLE Isolation of a human liver fructose-1,6-bisphosphatase cDNA and
expression of the protein in Escherichia coli. Role of ASP-118 and
ASP-121 in catalysis
JOURNAL J. Biol. Chem. 268 (13), 9466-9472 (1993)
PUBMED 8387495
COMMENT Original source text: Homo sapiens (library: Clonetech lambda gt11)
adult liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1401
/db_xref="H-InvDB:HIT000192012"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="parenchymal"
/tissue_type="liver"
/dev_stage="adult"
/tissue_lib="Clonetech lambda gt11"
CDS 143..1159
/EC_number="3.1.3.11"
/codon_start=1
/product="fructose-1,6-bisphosphatase"
/protein_id="AAA35817.1"
/translation="MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKA
ISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKH
AIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNL
VAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEAYAK
DFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKL
RLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEK
HSAQ"
regulatory 1382..1387
/regulatory_class="polyA_signal_sequence"
polyA_site 1401
BASE COUNT 324 a 394 c 369 g 314 t
ORIGIN
1 cgactgccgc cccgagtgtc cgcagcgctc gtggtgcagc tcgcacctgc ggccagtgcc
61 tactgccctc tcttgccgcc cgcacctgca gccccgcacc tgccgcttgc acctgcagcc
121 ccgcgctcta cccggttcaa gcatggctga ccaggcgccc ttcgacacgg acgtcaacac
181 cctgacccgc ttcgtcatgg aggagggcag gaaggcccgc ggcacgggcg agttgaccca
241 gctgctcaac tcgctctgca cagcagtcaa agccatctct tcggcggtgc gcaaggcggg
301 catcgcgcac ctctatggca ttgctggttc taccaacgtg acaggtgatc aagttaagaa
361 gctggacgtc ctctccaacg acctggttat gaacatgtta aagtcatcct ttgccacgtg
421 tgttctcgtg tcagaagaag ataaacacgc catcatagtg gaaccggaga aaaggggtaa
481 atatgtggtc tgttttgatc cccttgatgg atcttccaac atcgattgcc ttgtgtccgt
541 tggaaccatt tttggcatct atagaaagaa atcaactgat gagccttctg agaaggatgc
601 tctgcaacca ggccggaacc tggtggcagc cggctacgca ctgtatggca gtgccaccat
661 gctggtcctt gccatggact gtggggtcaa ctgcttcatg ctggacccgg ccatcgggga
721 gttcattttg gtggacaagg atgtgaagat aaaaaagaaa ggtaaaatct acagccttaa
781 cgaggcgtac gctaaggact ttgaccctgc cgtcactgag tacatccaga ggaagaagtt
841 ccccccagat aattcagctc cttatggggc ccggtatgtg ggctccatgg tggctgatgt
901 tcatcgcact ctggtctacg gagggatatt tctgtacccc gctaacaaga agagccccaa
961 tggaaagctg agactgctgt acgaatgcaa ccccatggcc tacgtcatgg agaaggctgg
1021 gggaatggcc accactggga aggaggccgt gttagacgtc attcccacag acattcacca
1081 gagggcgccg gtgatcttgg ggtcccccga cgacgtgctc gagttcctga aggtgtatga
1141 gaagcactct gcccagtgag cacctgccct gcctgcatcc tggagaattg cctctacctg
1201 gaccttttgt ctcacacagc agtaccctga cctgctgtgc accttacatt cctagagagc
1261 agaaataaaa agcatgacta tttccaccat caaatgctgt agaatgcttg gcactcccta
1321 accaaatgct gtctccataa tgccactggt gttaagatat attttgagtg gatggaggag
1381 aaataaactt attcctcctt a
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